ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1216	423/7206	3.6832116505e-54
ko04724	Glutamatergic synapse	93/1216	152/7206	2.33637624498e-35
ko05033	Nicotine addiction	49/1216	56/7206	4.13027280037e-31
ko05032	Morphine addiction	72/1216	110/7206	2.70890310429e-30
ko04727	GABAergic synapse	70/1216	110/7206	2.41872470567e-28
ko04713	Circadian entrainment	78/1216	136/7206	4.10560036669e-27
ko04728	Dopaminergic synapse	87/1216	185/7206	4.39839557327e-22
ko04725	Cholinergic synapse	78/1216	160/7206	4.1278527867e-21
ko04721	Synaptic vesicle cycle	51/1216	80/7206	5.35336450462e-21
ko04723	Retrograde endocannabinoid signaling	81/1216	175/7206	4.39527347911e-20
ko04024	cAMP signaling pathway	108/1216	279/7206	5.3341467255e-19
ko04020	Calcium signaling pathway	102/1216	265/7206	1.43991336821e-17
ko04726	Serotonergic synapse	64/1216	137/7206	2.38312499738e-16
ko04911	Insulin secretion	57/1216	117/7206	1.01860677402e-15
ko04744	Phototransduction	28/1216	36/7206	1.33551209659e-15
ko04742	Taste transduction	37/1216	61/7206	1.45578149589e-14
ko04921	Oxytocin signaling pathway	80/1216	209/7206	5.91233474958e-14
ko05031	Amphetamine addiction	44/1216	91/7206	2.79180769271e-12
ko04720	Long-term potentiation	46/1216	99/7206	5.2996981787e-12
ko04970	Salivary secretion	43/1216	95/7206	7.67449558628e-11
ko04261	Adrenergic signaling in cardiomyocytes	71/1216	205/7206	4.92758663145e-10
ko03010	Ribosome	1/1216	129/7206	1.53227100929e-09
ko03040	Spliceosome	2/1216	145/7206	1.56317993729e-09
ko04925	Aldosterone synthesis and secretion	43/1216	105/7206	3.59711474062e-09
ko04971	Gastric acid secretion	39/1216	98/7206	6.11565822267e-08
ko04740	Olfactory transduction	33/1216	80/7206	1.94448158582e-07
ko05030	Cocaine addiction	31/1216	73/7206	2.08222870564e-07
ko04022	cGMP-PKG signaling pathway	65/1216	216/7206	1.12551563118e-06
ko05322	Systemic lupus erythematosus	6/1216	151/7206	1.47049335894e-06
ko05168	Herpes simplex infection	9/1216	182/7206	1.63189263158e-06
ko05203	Viral carcinogenesis	20/1216	277/7206	2.48221275772e-06
ko03013	RNA transport	8/1216	166/7206	2.87536326218e-06
ko04360	Axon guidance	67/1216	233/7206	4.4725100846e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1216	74/7206	4.77005085762e-06
ko04060	Cytokine-cytokine receptor interaction	11/1216	191/7206	5.08404391187e-06
ko04010	MAPK signaling pathway	86/1216	321/7206	5.70312273938e-06
ko04070	Phosphatidylinositol signaling system	38/1216	112/7206	9.54580241439e-06
ko04621	NOD-like receptor signaling pathway	8/1216	157/7206	1.19650679684e-05
ko04745	Phototransduction - fly	18/1216	38/7206	1.21610945287e-05
ko04141	Protein processing in endoplasmic reticulum	11/1216	184/7206	1.39834211209e-05
ko04972	Pancreatic secretion	37/1216	111/7206	1.80203119155e-05
ko04966	Collecting duct acid secretion	14/1216	26/7206	1.8166839724e-05
ko04730	Long-term depression	29/1216	78/7206	2.10797167797e-05
ko05164	Influenza A	10/1216	167/7206	3.67126930509e-05
ko04014	Ras signaling pathway	74/1216	279/7206	3.95200246492e-05
ko04072	Phospholipase D signaling pathway	56/1216	197/7206	4.1990394029e-05
ko04514	Cell adhesion molecules (CAMs)	41/1216	130/7206	4.24856361327e-05
ko04540	Gap junction	40/1216	128/7206	6.28698476641e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1216	79/7206	0.00011009263244
ko04924	Renin secretion	29/1216	86/7206	0.000120496980565
ko04612	Antigen processing and presentation	2/1216	77/7206	0.00016674652753
ko04110	Cell cycle	9/1216	145/7206	0.000186840194138
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1216	79/7206	0.000195841848015
ko04750	Inflammatory mediator regulation of TRP channels	37/1216	122/7206	0.000207207292551
ko05414	Dilated cardiomyopathy	34/1216	112/7206	0.000329138628224
ko04710	Circadian rhythm	17/1216	43/7206	0.000335663457565
ko05169	Epstein-Barr virus infection	17/1216	206/7206	0.00043503800576
ko05110	Vibrio cholerae infection	22/1216	63/7206	0.000504932957708
ko04923	Regulation of lipolysis in adipocytes	25/1216	77/7206	0.000657479629137
ko04610	Complement and coagulation cascades	3/1216	79/7206	0.00070039460108
ko04915	Estrogen signaling pathway	37/1216	131/7206	0.000915421454106
ko04260	Cardiac muscle contraction	30/1216	98/7206	0.000921138374297
ko04120	Ubiquitin mediated proteolysis	10/1216	138/7206	0.00121853019591
ko05162	Measles	8/1216	120/7206	0.00129904308246
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1216	59/7206	0.00131456382196
ko00240	Pyrimidine metabolism	7/1216	110/7206	0.00183890120033
ko04973	Carbohydrate digestion and absorption	15/1216	42/7206	0.00290165383246
ko04064	NF-kappa B signaling pathway	6/1216	96/7206	0.00355116167662
ko04976	Bile secretion	24/1216	80/7206	0.00375717579328
ko03022	Basal transcription factors	1/1216	44/7206	0.00431102329269
ko05144	Malaria	1/1216	45/7206	0.00432810474661
ko00071	Fatty acid degradation	1/1216	45/7206	0.00432810474661
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1216	14/7206	0.00437646171225
ko03420	Nucleotide excision repair	1/1216	46/7206	0.00452382656709
ko04912	GnRH signaling pathway	33/1216	122/7206	0.00464660891008
ko05205	Proteoglycans in cancer	29/1216	271/7206	0.00480160496571
ko00480	Glutathione metabolism	2/1216	55/7206	0.0057008117882
ko04626	Plant-pathogen interaction	8/1216	18/7206	0.00571081856387
ko04922	Glucagon signaling pathway	34/1216	128/7206	0.00573191005841
ko04371	Apelin signaling pathway	44/1216	177/7206	0.00589416466243
ko04214	Apoptosis - fly	4/1216	72/7206	0.00667343149856
ko05131	Shigellosis	5/1216	82/7206	0.0068906202848
ko04658	Th1 and Th2 cell differentiation	7/1216	96/7206	0.008764789019
ko04930	Type II diabetes mellitus	17/1216	54/7206	0.00914753383986
ko04657	IL-17 signaling pathway	6/1216	87/7206	0.00916223118418
ko05133	Pertussis	6/1216	87/7206	0.00916223118418
ko04622	RIG-I-like receptor signaling pathway	3/1216	62/7206	0.00939459994149
ko05161	Hepatitis B	17/1216	173/7206	0.0100607672135
ko05231	Choline metabolism in cancer	34/1216	134/7206	0.010378095003
ko05145	Toxoplasmosis	11/1216	126/7206	0.0114245597286
ko05140	Leishmaniasis	5/1216	75/7206	0.013049174298
ko04630	Jak-STAT signaling pathway	12/1216	132/7206	0.0135091162241
ko03410	Base excision repair	1/1216	38/7206	0.0148283312754
ko04015	Rap1 signaling pathway	62/1216	278/7206	0.0175764852938
ko00310	Lysine degradation	5/1216	73/7206	0.01795314922
ko05219	Bladder cancer	2/1216	48/7206	0.0180846764596
ko04115	p53 signaling pathway	5/1216	74/7206	0.0181437357698
ko05321	Inflammatory bowel disease (IBD)	3/1216	56/7206	0.0184964795586
ko04960	Aldosterone-regulated sodium reabsorption	13/1216	41/7206	0.0189923399488
ko04918	Thyroid hormone synthesis	23/1216	86/7206	0.0196264054838
ko05016	Huntington's disease	24/1216	215/7206	0.0208366268007
ko04964	Proximal tubule bicarbonate reclamation	10/1216	29/7206	0.0211750417393
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1216	100/7206	0.0212230896363
ko04146	Peroxisome	7/1216	89/7206	0.0217249807214
ko00500	Starch and sucrose metabolism	1/1216	35/7206	0.0218777994111
ko04217	Necroptosis	19/1216	178/7206	0.0253414720995
ko00330	Arginine and proline metabolism	4/1216	61/7206	0.0257320067559
ko04330	Notch signaling pathway	4/1216	62/7206	0.0257575240429
ko00280	Valine, leucine and isoleucine degradation	3/1216	54/7206	0.0265776702979
ko04510	Focal adhesion	28/1216	240/7206	0.0281774173307
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1216	15/7206	0.0288409112952
ko03320	PPAR signaling pathway	5/1216	69/7206	0.0341344255294
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1216	182/7206	0.0346417737388
ko00140	Steroid hormone biosynthesis	2/1216	41/7206	0.036099495471
ko00983	Drug metabolism - other enzymes	2/1216	42/7206	0.0365005610726
ko05166	HTLV-I infection	36/1216	292/7206	0.0376725349459
ko04270	Vascular smooth muscle contraction	36/1216	154/7206	0.0379848940797
ko03018	RNA degradation	7/1216	84/7206	0.038839675041
ko05132	Salmonella infection	9/1216	98/7206	0.0410671320792
ko04062	Chemokine signaling pathway	45/1216	201/7206	0.044187653974
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1216	92/7206	0.0483238573876
ko05340	Primary immunodeficiency	1/1216	30/7206	0.0486263225148
ko05214	Glioma	20/1216	79/7206	0.0495745819157