ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 43/712 80/7206 4.59957498817e-23 ko04724 Glutamatergic synapse 58/712 152/7206 4.01399919022e-21 ko05033 Nicotine addiction 31/712 56/7206 1.89333143902e-17 ko04728 Dopaminergic synapse 59/712 185/7206 4.29530585725e-17 ko04080 Neuroactive ligand-receptor interaction 95/712 423/7206 2.74421021425e-15 ko04727 GABAergic synapse 41/712 110/7206 7.73821182258e-15 ko05032 Morphine addiction 41/712 110/7206 7.73821182258e-15 ko04713 Circadian entrainment 44/712 136/7206 2.80103187111e-13 ko04723 Retrograde endocannabinoid signaling 49/712 175/7206 5.42866523547e-12 ko04911 Insulin secretion 38/712 117/7206 1.07551370814e-11 ko04725 Cholinergic synapse 43/712 160/7206 4.75034508744e-10 ko04744 Phototransduction 17/712 36/7206 9.58871085816e-09 ko04024 cAMP signaling pathway 58/712 279/7206 2.70823714061e-08 ko05031 Amphetamine addiction 27/712 91/7206 9.39563193295e-08 ko05030 Cocaine addiction 23/712 73/7206 2.53469496299e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 23/712 74/7206 3.34114593434e-07 ko04726 Serotonergic synapse 33/712 137/7206 1.39586320035e-06 ko04966 Collecting duct acid secretion 12/712 26/7206 2.06781080426e-06 ko04514 Cell adhesion molecules (CAMs) 30/712 130/7206 7.89715065675e-06 ko04261 Adrenergic signaling in cardiomyocytes 41/712 205/7206 8.10506656988e-06 ko04120 Ubiquitin mediated proteolysis 1/712 138/7206 1.68064430574e-05 ko04360 Axon guidance 43/712 233/7206 4.57402036191e-05 ko03040 Spliceosome 2/712 145/7206 5.98462001614e-05 ko04720 Long-term potentiation 23/712 99/7206 0.000101952218717 ko04010 MAPK signaling pathway 53/712 321/7206 0.00016396160455 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/712 14/7206 0.000164560362898 ko04060 Cytokine-cytokine receptor interaction 5/712 191/7206 0.000178914010676 ko04964 Proximal tubule bicarbonate reclamation 10/712 29/7206 0.000290951605985 ko03013 RNA transport 4/712 166/7206 0.00030611267381 ko04970 Salivary secretion 21/712 95/7206 0.00035028727198 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/712 59/7206 0.000454727881044 ko05110 Vibrio cholerae infection 15/712 63/7206 0.000957561400967 ko05168 Herpes simplex infection 6/712 182/7206 0.000995369148363 ko04141 Protein processing in endoplasmic reticulum 6/712 184/7206 0.00100000844381 ko04391 Hippo signaling pathway - fly 19/712 90/7206 0.00113098970082 ko04972 Pancreatic secretion 22/712 111/7206 0.00118986688365 ko05205 Proteoglycans in cancer 12/712 271/7206 0.00119259535947 ko04260 Cardiac muscle contraction 20/712 98/7206 0.00163625907912 ko04921 Oxytocin signaling pathway 35/712 209/7206 0.00198083964146 ko04742 Taste transduction 14/712 61/7206 0.00204128112632 ko04621 NOD-like receptor signaling pathway 5/712 157/7206 0.00257546610795 ko05322 Systemic lupus erythematosus 5/712 151/7206 0.00348333650309 ko05164 Influenza A 6/712 167/7206 0.00355246285541 ko05203 Viral carcinogenesis 14/712 277/7206 0.00394231356112 ko03008 Ribosome biogenesis in eukaryotes 1/712 79/7206 0.00403084724062 ko04924 Renin secretion 17/712 86/7206 0.00522680173829 ko04976 Bile secretion 16/712 80/7206 0.00678336722429 ko04540 Gap junction 22/712 128/7206 0.0100183845859 ko04022 cGMP-PKG signaling pathway 33/712 216/7206 0.0104320041468 ko04146 Peroxisome 2/712 89/7206 0.0109602874913 ko04145 Phagosome 26/712 162/7206 0.0111536322521 ko04730 Long-term depression 15/712 78/7206 0.0112465015007 ko05120 Epithelial cell signaling in Helicobacter pylori infection 17/712 92/7206 0.0120577904525 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 15/712 79/7206 0.0120639199933 ko00561 Glycerolipid metabolism 1/712 63/7206 0.0186349297815 ko04640 Hematopoietic cell lineage 1/712 64/7206 0.0187788158968 ko04137 Mitophagy - animal 2/712 82/7206 0.0229440332092 ko04064 NF-kappa B signaling pathway 3/712 96/7206 0.0234217890829 ko04014 Ras signaling pathway 39/712 279/7206 0.0239881413145 ko04915 Estrogen signaling pathway 21/712 131/7206 0.0252757998021 ko05034 Alcoholism 34/712 238/7206 0.0265222361832 ko04962 Vasopressin-regulated water reabsorption 11/712 58/7206 0.0270674184054 ko05162 Measles 5/712 120/7206 0.0302998529948 ko05140 Leishmaniasis 2/712 75/7206 0.0309513854338 ko04973 Carbohydrate digestion and absorption 9/712 42/7206 0.031816756522 ko04140 Autophagy - animal 8/712 164/7206 0.0327858203973 ko04740 Olfactory transduction 14/712 80/7206 0.0350256327093 ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series 3/712 8/7206 0.0368295107702 ko04971 Gastric acid secretion 16/712 98/7206 0.0395625621394 ko00480 Glutathione metabolism 1/712 55/7206 0.0396807109589 ko05321 Inflammatory bowel disease (IBD) 1/712 56/7206 0.0400824916383 ko00310 Lysine degradation 2/712 73/7206 0.0451521777092 ko04020 Calcium signaling pathway 36/712 265/7206 0.0457589082408 ko04745 Phototransduction - fly 8/712 38/7206 0.0484867274354 ko05167 Kaposi's sarcoma-associated herpesvirus infection 27/712 191/7206 0.0494782706676