ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 30/475 152/7206 3.97350897139e-08 ko04713 Circadian entrainment 27/475 136/7206 1.69850867231e-07 ko04911 Insulin secretion 24/475 117/7206 4.42670439179e-07 ko04725 Cholinergic synapse 27/475 160/7206 4.7705582906e-06 ko05031 Amphetamine addiction 19/475 91/7206 5.39183220419e-06 ko04921 Oxytocin signaling pathway 32/475 209/7206 6.01255413835e-06 ko04922 Glucagon signaling pathway 23/475 128/7206 8.33548114411e-06 ko04971 Gastric acid secretion 19/475 98/7206 1.66940923699e-05 ko04720 Long-term potentiation 19/475 99/7206 1.94212223046e-05 ko04022 cGMP-PKG signaling pathway 31/475 216/7206 3.42776372194e-05 ko04020 Calcium signaling pathway 36/475 265/7206 3.67693682923e-05 ko04970 Salivary secretion 18/475 95/7206 3.84141139282e-05 ko04925 Aldosterone synthesis and secretion 19/475 105/7206 4.58963095361e-05 ko04070 Phosphatidylinositol signaling system 19/475 112/7206 0.000113964627875 ko04966 Collecting duct acid secretion 8/475 26/7206 0.000182028559142 ko04728 Dopaminergic synapse 26/475 185/7206 0.000220922905653 ko04960 Aldosterone-regulated sodium reabsorption 10/475 41/7206 0.000246291942778 ko04727 GABAergic synapse 18/475 110/7206 0.000273844545522 ko04726 Serotonergic synapse 21/475 137/7206 0.000304115178102 ko04024 cAMP signaling pathway 34/475 279/7206 0.000470303291209 ko04261 Adrenergic signaling in cardiomyocytes 27/475 205/7206 0.000487146551246 ko04745 Phototransduction - fly 9/475 38/7206 0.000634120562357 ko04138 Autophagy - yeast 14/475 81/7206 0.000734605798669 ko04626 Plant-pathogen interaction 6/475 18/7206 0.000745338336741 ko03040 Spliceosome 1/475 145/7206 0.00101951589841 ko04730 Long-term depression 13/475 78/7206 0.00159256694345 ko04710 Circadian rhythm 9/475 43/7206 0.00163417935479 ko04371 Apelin signaling pathway 23/475 177/7206 0.00174257739846 ko04721 Synaptic vesicle cycle 13/475 80/7206 0.00201773420335 ko04964 Proximal tubule bicarbonate reclamation 7/475 29/7206 0.002260742722 ko04137 Mitophagy - animal 13/475 82/7206 0.00253233139057 ko03010 Ribosome 1/475 129/7206 0.00331989139929 ko04136 Autophagy - other 7/475 31/7206 0.00339666070061 ko04924 Renin secretion 13/475 86/7206 0.00388474680152 ko04918 Thyroid hormone synthesis 13/475 86/7206 0.00388474680152 ko00680 Methane metabolism 7/475 34/7206 0.00585492457905 ko00010 Glycolysis / Gluconeogenesis 11/475 74/7206 0.00865215152921 ko04066 HIF-1 signaling pathway 16/475 123/7206 0.0087054735945 ko04919 Thyroid hormone signaling pathway 18/475 143/7206 0.00919054338101 ko05168 Herpes simplex infection 4/475 182/7206 0.0098345425957 ko04068 FoxO signaling pathway 20/475 167/7206 0.0102699606188 ko05167 Kaposi's sarcoma-associated herpesvirus infection 22/475 191/7206 0.0108513118691 ko04080 Neuroactive ligand-receptor interaction 41/475 423/7206 0.0112709262569 ko04014 Ras signaling pathway 29/475 279/7206 0.0133050414779 ko04961 Endocrine and other factor-regulated calcium reabsorption 9/475 59/7206 0.0143073415063 ko04750 Inflammatory mediator regulation of TRP channels 15/475 122/7206 0.0160652534675 ko05032 Morphine addiction 14/475 110/7206 0.0175062735138 ko05322 Systemic lupus erythematosus 3/475 151/7206 0.0186083604022 ko00051 Fructose and mannose metabolism 7/475 42/7206 0.0186525633232 ko04270 Vascular smooth muscle contraction 18/475 154/7206 0.0195590801654 ko04114 Oocyte meiosis 16/475 139/7206 0.0243778228528 ko03013 RNA transport 4/475 166/7206 0.0253120639704 ko04540 Gap junction 15/475 128/7206 0.0285349600732 ko05014 Amyotrophic lateral sclerosis (ALS) 10/475 74/7206 0.0287997455159 ko04360 Axon guidance 24/475 233/7206 0.030288807222 ko04514 Cell adhesion molecules (CAMs) 15/475 130/7206 0.0305139174445 ko04915 Estrogen signaling pathway 15/475 131/7206 0.0316367239561 ko04144 Endocytosis 13/475 342/7206 0.0331493172577 ko05110 Vibrio cholerae infection 9/475 63/7206 0.034743824135 ko04650 Natural killer cell mediated cytotoxicity 12/475 97/7206 0.0351777524186 ko00120 Primary bile acid biosynthesis 4/475 20/7206 0.0388525227581 ko04740 Olfactory transduction 10/475 80/7206 0.0405921666226 ko05224 Breast cancer 5/475 174/7206 0.0435049393163 ko04978 Mineral absorption 6/475 40/7206 0.0452153033489 ko04657 IL-17 signaling pathway 1/475 87/7206 0.0454201139564 ko04015 Rap1 signaling pathway 27/475 278/7206 0.0471044295209 ko00562 Inositol phosphate metabolism 11/475 89/7206 0.0476781326422 ko04711 Circadian rhythm - fly 3/475 13/7206 0.049591995045 ko04972 Pancreatic secretion 13/475 111/7206 0.0497618441904