ko pathway ratio_in_study ratio_in_pop p_value ko05032 Morphine addiction 15/181 110/7206 8.18884606835e-08 ko04070 Phosphatidylinositol signaling system 12/181 112/7206 2.166901178e-05 ko04723 Retrograde endocannabinoid signaling 15/181 175/7206 3.04911768752e-05 ko04725 Cholinergic synapse 14/181 160/7206 4.50205756108e-05 ko04921 Oxytocin signaling pathway 16/181 209/7206 6.59405414263e-05 ko04727 GABAergic synapse 11/181 110/7206 9.09881767196e-05 ko04911 Insulin secretion 11/181 117/7206 0.000158997630753 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/181 14/7206 0.000316439983843 ko04713 Circadian entrainment 11/181 136/7206 0.000590353933461 ko04726 Serotonergic synapse 11/181 137/7206 0.000628104402127 ko04728 Dopaminergic synapse 13/181 185/7206 0.000737256337996 ko04721 Synaptic vesicle cycle 8/181 80/7206 0.000840685294521 ko04724 Glutamatergic synapse 11/181 152/7206 0.0014830308702 ko04930 Type II diabetes mellitus 6/181 54/7206 0.0021945032448 ko04024 cAMP signaling pathway 16/181 279/7206 0.0023936778587 ko05033 Nicotine addiction 6/181 56/7206 0.00264708757401 ko04080 Neuroactive ligand-receptor interaction 21/181 423/7206 0.00323873446292 ko04742 Taste transduction 6/181 61/7206 0.00408307220861 ko00562 Inositol phosphate metabolism 7/181 89/7206 0.00684447535217 ko04071 Sphingolipid signaling pathway 10/181 162/7206 0.00747863457613 ko04010 MAPK signaling pathway 16/181 321/7206 0.00894361241983 ko04923 Regulation of lipolysis in adipocytes 6/181 77/7206 0.0125522391357 ko04371 Apelin signaling pathway 10/181 177/7206 0.0134762425687 ko04925 Aldosterone synthesis and secretion 7/181 105/7206 0.0162071515295 ko04360 Axon guidance 12/181 233/7206 0.0165564121333 ko04924 Renin secretion 6/181 86/7206 0.0207144338086 ko04931 Insulin resistance 8/181 137/7206 0.0217367347505 ko04022 cGMP-PKG signaling pathway 11/181 216/7206 0.0236728233145 ko04020 Calcium signaling pathway 13/181 265/7206 0.0241778344396 ko04970 Salivary secretion 6/181 95/7206 0.0318945474155 ko04750 Inflammatory mediator regulation of TRP channels 7/181 122/7206 0.0335669443764 ko04260 Cardiac muscle contraction 6/181 98/7206 0.0363528382385 ko04261 Adrenergic signaling in cardiomyocytes 10/181 205/7206 0.0384500531879 ko05142 Chagas disease (American trypanosomiasis) 7/181 130/7206 0.0449117893068