ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	109/1055	145/7206	7.03572287872e-62
ko03013	RNA transport	86/1055	166/7206	3.8268153057e-30
ko04110	Cell cycle	75/1055	145/7206	2.50387084193e-26
ko03008	Ribosome biogenesis in eukaryotes	51/1055	79/7206	2.89384686536e-24
ko03030	DNA replication	31/1055	38/7206	4.12880238254e-20
ko04111	Cell cycle - yeast	50/1055	90/7206	1.09538883246e-19
ko03460	Fanconi anemia pathway	34/1055	51/7206	3.16212172429e-17
ko04020	Calcium signaling pathway	2/1055	265/7206	5.14683789911e-16
ko03015	mRNA surveillance pathway	46/1055	93/7206	1.32542244896e-15
ko05322	Systemic lupus erythematosus	59/1055	151/7206	8.69951004402e-14
ko04144	Endocytosis	10/1055	342/7206	2.96679075841e-13
ko03410	Base excision repair	25/1055	38/7206	8.49067090071e-13
ko04113	Meiosis - yeast	35/1055	70/7206	2.34691940778e-12
ko03440	Homologous recombination	25/1055	41/7206	1.03637376024e-11
ko03018	RNA degradation	38/1055	84/7206	1.34478451222e-11
ko00240	Pyrimidine metabolism	44/1055	110/7206	5.2908499514e-11
ko03430	Mismatch repair	17/1055	22/7206	7.39316136159e-11
ko05010	Alzheimer's disease	3/1055	202/7206	1.0826700606e-10
ko03420	Nucleotide excision repair	25/1055	46/7206	3.33032370435e-10
ko03022	Basal transcription factors	24/1055	44/7206	6.84353673726e-10
ko03020	RNA polymerase	18/1055	29/7206	5.80958358823e-09
ko04723	Retrograde endocannabinoid signaling	3/1055	175/7206	6.62306016615e-09
ko04270	Vascular smooth muscle contraction	2/1055	154/7206	1.20435045738e-08
ko04724	Glutamatergic synapse	2/1055	152/7206	1.83724952324e-08
ko04024	cAMP signaling pathway	12/1055	279/7206	2.07402044896e-08
ko04921	Oxytocin signaling pathway	6/1055	209/7206	2.2522448732e-08
ko05203	Viral carcinogenesis	74/1055	277/7206	8.46838725219e-08
ko04932	Non-alcoholic fatty liver disease (NAFLD)	5/1055	182/7206	1.07486230581e-07
ko05012	Parkinson's disease	3/1055	155/7206	1.09612428919e-07
ko04022	cGMP-PKG signaling pathway	8/1055	216/7206	2.2175834912e-07
ko05034	Alcoholism	65/1055	238/7206	3.00593553884e-07
ko04072	Phospholipase D signaling pathway	7/1055	197/7206	5.61776170785e-07
ko04510	Focal adhesion	11/1055	240/7206	6.08857284931e-07
ko04060	Cytokine-cytokine receptor interaction	7/1055	191/7206	1.14734946979e-06
ko04726	Serotonergic synapse	3/1055	137/7206	1.18418062313e-06
ko04062	Chemokine signaling pathway	8/1055	201/7206	1.30383854774e-06
ko04725	Cholinergic synapse	5/1055	160/7206	2.24219008633e-06
ko04621	NOD-like receptor signaling pathway	5/1055	157/7206	3.24821146995e-06
ko04260	Cardiac muscle contraction	1/1055	98/7206	4.53370365758e-06
ko05169	Epstein-Barr virus infection	55/1055	206/7206	4.90216986785e-06
ko05414	Dilated cardiomyopathy	2/1055	112/7206	5.49668653801e-06
ko04970	Salivary secretion	1/1055	95/7206	6.89375711441e-06
ko04974	Protein digestion and absorption	1/1055	96/7206	6.90682944472e-06
ko04727	GABAergic synapse	2/1055	110/7206	8.20824868802e-06
ko04611	Platelet activation	6/1055	163/7206	8.44190710305e-06
ko04014	Ras signaling pathway	17/1055	279/7206	8.684195518e-06
ko04915	Estrogen signaling pathway	4/1055	131/7206	1.65304184105e-05
ko05217	Basal cell carcinoma	24/1055	68/7206	1.70093046843e-05
ko03010	Ribosome	4/1055	129/7206	2.40163392925e-05
ko04920	Adipocytokine signaling pathway	1/1055	89/7206	2.5337670693e-05
ko04261	Adrenergic signaling in cardiomyocytes	11/1055	205/7206	3.28582382875e-05
ko04010	MAPK signaling pathway	23/1055	321/7206	3.45159852936e-05
ko04810	Regulation of actin cytoskeleton	17/1055	264/7206	3.87289666775e-05
ko04971	Gastric acid secretion	2/1055	98/7206	4.04520615101e-05
ko05146	Amoebiasis	2/1055	99/7206	4.05335270825e-05
ko05410	Hypertrophic cardiomyopathy (HCM)	2/1055	100/7206	4.18841558638e-05
ko04713	Circadian entrainment	5/1055	136/7206	4.23513484482e-05
ko05032	Morphine addiction	3/1055	110/7206	5.75645674392e-05
ko04380	Osteoclast differentiation	5/1055	134/7206	6.0766718891e-05
ko04912	GnRH signaling pathway	4/1055	122/7206	7.63457898258e-05
ko04371	Apelin signaling pathway	9/1055	177/7206	8.57357233846e-05
ko04911	Insulin secretion	4/1055	117/7206	0.000105585601747
ko04670	Leukocyte transendothelial migration	7/1055	151/7206	0.000106817542495
ko04151	PI3K-Akt signaling pathway	32/1055	390/7206	0.000117582980304
ko04514	Cell adhesion molecules (CAMs)	5/1055	130/7206	0.000130575341667
ko05145	Toxoplasmosis	5/1055	126/7206	0.000179023313465
ko05133	Pertussis	2/1055	87/7206	0.000195065617715
ko05140	Leishmaniasis	1/1055	75/7206	0.000196016793276
ko04662	B cell receptor signaling pathway	2/1055	88/7206	0.000196694240139
ko04550	Signaling pathways regulating pluripotency of stem cells	42/1055	165/7206	0.000206244527688
ko04972	Pancreatic secretion	4/1055	111/7206	0.000219638632393
ko04750	Inflammatory mediator regulation of TRP channels	5/1055	122/7206	0.000251567150868
ko04660	T cell receptor signaling pathway	5/1055	124/7206	0.000261805540072
ko04620	Toll-like receptor signaling pathway	3/1055	100/7206	0.000273212630228
ko04630	Jak-STAT signaling pathway	6/1055	132/7206	0.00027620985359
ko05202	Transcriptional misregulation in cancer	46/1055	188/7206	0.000327873077609
ko04668	TNF signaling pathway	5/1055	120/7206	0.000359946703497
ko04650	Natural killer cell mediated cytotoxicity	3/1055	97/7206	0.000393920954254
ko04330	Notch signaling pathway	20/1055	62/7206	0.000395186700845
ko00230	Purine metabolism	47/1055	194/7206	0.000404518719088
ko04910	Insulin signaling pathway	10/1055	172/7206	0.000415737846943
ko03320	PPAR signaling pathway	1/1055	69/7206	0.000434047773119
ko05120	Epithelial cell signaling in Helicobacter pylori infection	3/1055	92/7206	0.000548979671855
ko04931	Insulin resistance	7/1055	137/7206	0.000565066035999
ko04976	Bile secretion	2/1055	80/7206	0.00063938033957
ko04740	Olfactory transduction	2/1055	80/7206	0.00063938033957
ko05166	HTLV-I infection	64/1055	292/7206	0.000674178535516
ko04925	Aldosterone synthesis and secretion	4/1055	105/7206	0.000676765605133
ko04728	Dopaminergic synapse	12/1055	185/7206	0.000698605590993
ko05152	Tuberculosis	12/1055	187/7206	0.00071034289748
ko05231	Choline metabolism in cancer	7/1055	134/7206	0.000783284478937
ko04120	Ubiquitin mediated proteolysis	35/1055	138/7206	0.000883316180911
ko04923	Regulation of lipolysis in adipocytes	2/1055	77/7206	0.000934857907087
ko00561	Glycerolipid metabolism	1/1055	63/7206	0.000965041088732
ko04640	Hematopoietic cell lineage	1/1055	64/7206	0.00100553535778
ko04350	TGF-beta signaling pathway	28/1055	103/7206	0.00100933577248
ko04070	Phosphatidylinositol signaling system	5/1055	112/7206	0.001031776439
ko05160	Hepatitis C	9/1055	153/7206	0.00107514469744
ko04712	Circadian rhythm - plant	5/1055	7/7206	0.00108191675985
ko04530	Tight junction	17/1055	228/7206	0.00112701316286
ko04340	Hedgehog signaling pathway	18/1055	58/7206	0.00121581111495
ko05132	Salmonella infection	4/1055	98/7206	0.0013222540381
ko04015	Rap1 signaling pathway	23/1055	278/7206	0.00133516498023
ko00564	Glycerophospholipid metabolism	4/1055	99/7206	0.00135949584153
ko04961	Endocrine and other factor-regulated calcium reabsorption	1/1055	59/7206	0.00143681802894
ko01212	Fatty acid metabolism	1/1055	60/7206	0.00144045994802
ko01200	Carbon metabolism	7/1055	128/7206	0.00149323735455
ko04540	Gap junction	7/1055	128/7206	0.00149323735455
ko05142	Chagas disease (American trypanosomiasis)	7/1055	130/7206	0.00153121004835
ko04924	Renin secretion	3/1055	86/7206	0.00175058407354
ko04310	Wnt signaling pathway	42/1055	181/7206	0.00186570460222
ko05168	Herpes simplex infection	42/1055	182/7206	0.00196389318498
ko04933	AGE-RAGE signaling pathway in diabetic complications	8/1055	135/7206	0.00202004779651
ko04659	Th17 cell differentiation	5/1055	106/7206	0.00202333916505
ko04390	Hippo signaling pathway	43/1055	188/7206	0.00226763559056
ko05031	Amphetamine addiction	4/1055	91/7206	0.00264021712808
ko04066	HIF-1 signaling pathway	7/1055	123/7206	0.00282466783688
ko04930	Type II diabetes mellitus	1/1055	54/7206	0.00321224719383
ko00280	Valine, leucine and isoleucine degradation	1/1055	54/7206	0.00321224719383
ko04142	Lysosome	10/1055	151/7206	0.00337372856033
ko04730	Long-term depression	3/1055	78/7206	0.00341225353407
ko05321	Inflammatory bowel disease (IBD)	1/1055	56/7206	0.00344380069369
ko04012	ErbB signaling pathway	6/1055	109/7206	0.00390623993686
ko04071	Sphingolipid signaling pathway	12/1055	162/7206	0.00666364662406
ko05030	Cocaine addiction	3/1055	73/7206	0.00700923045819
ko04114	Oocyte meiosis	32/1055	139/7206	0.00734829095175
ko04722	Neurotrophin signaling pathway	12/1055	160/7206	0.00880965472357
ko04666	Fc gamma R-mediated phagocytosis	8/1055	122/7206	0.00917967337716
ko00071	Fatty acid degradation	1/1055	45/7206	0.0106764184392
ko04922	Glucagon signaling pathway	9/1055	128/7206	0.0112551614842
ko04720	Long-term potentiation	6/1055	99/7206	0.0139460725061
ko04370	VEGF signaling pathway	4/1055	77/7206	0.014374799567
ko04146	Peroxisome	5/1055	89/7206	0.0145867513661
ko00562	Inositol phosphate metabolism	5/1055	89/7206	0.0145867513661
ko03450	Non-homologous end-joining	6/1055	15/7206	0.0148886937076
ko04512	ECM-receptor interaction	4/1055	79/7206	0.0149583383012
ko04139	Mitophagy - yeast	11/1055	37/7206	0.0168390425866
ko00670	One carbon pool by folate	7/1055	20/7206	0.019214081999
ko00600	Sphingolipid metabolism	3/1055	63/7206	0.0198612454378
ko04213	Longevity regulating pathway - multiple species	5/1055	86/7206	0.0199354027589
ko04360	Axon guidance	22/1055	233/7206	0.0232733341551
ko00051	Fructose and mannose metabolism	1/1055	42/7206	0.0250633255491
ko04973	Carbohydrate digestion and absorption	1/1055	42/7206	0.0250633255491
ko00565	Ether lipid metabolism	1/1055	42/7206	0.0250633255491
ko05230	Central carbon metabolism in cancer	5/1055	81/7206	0.0264740866458
ko04138	Autophagy - yeast	5/1055	81/7206	0.0264740866458
ko00590	Arachidonic acid metabolism	2/1055	52/7206	0.0277138294554
ko04622	RIG-I-like receptor signaling pathway	3/1055	62/7206	0.0283885611661
ko05100	Bacterial invasion of epithelial cells	7/1055	99/7206	0.0309370768276
ko04152	AMPK signaling pathway	14/1055	161/7206	0.0315220157758
ko04145	Phagosome	14/1055	162/7206	0.0318245174481
ko00514	Other types of O-glycan biosynthesis	9/1055	30/7206	0.0323840509011
ko00630	Glyoxylate and dicarboxylate metabolism	1/1055	38/7206	0.0353392990317
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	5/1055	79/7206	0.0361568195993
ko01521	EGFR tyrosine kinase inhibitor resistance	8/1055	106/7206	0.0371446142486
ko05167	Kaposi's sarcoma-associated herpesvirus infection	18/1055	191/7206	0.0378302868906
ko05211	Renal cell carcinoma	7/1055	96/7206	0.0409593099512
ko04658	Th1 and Th2 cell differentiation	7/1055	96/7206	0.0409593099512
ko04140	Autophagy - animal	15/1055	164/7206	0.0440234710064
ko04917	Prolactin signaling pathway	6/1055	87/7206	0.0455058867031
ko04657	IL-17 signaling pathway	6/1055	87/7206	0.0455058867031
ko04664	Fc epsilon RI signaling pathway	5/1055	77/7206	0.0496205747125