ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	91/955	152/7206	2.14754538595e-42
ko04080	Neuroactive ligand-receptor interaction	159/955	423/7206	2.85686957915e-39
ko05033	Nicotine addiction	50/955	56/7206	6.15091972247e-38
ko04727	GABAergic synapse	69/955	110/7206	3.99446956066e-34
ko05032	Morphine addiction	67/955	110/7206	5.11832696458e-32
ko04713	Circadian entrainment	70/955	136/7206	3.78934138461e-27
ko04728	Dopaminergic synapse	82/955	185/7206	6.43067391864e-26
ko04723	Retrograde endocannabinoid signaling	77/955	175/7206	3.91075164904e-24
ko04725	Cholinergic synapse	71/955	160/7206	1.37728605649e-22
ko04024	cAMP signaling pathway	94/955	279/7206	2.86608378377e-19
ko04911	Insulin secretion	55/955	117/7206	3.65229032897e-19
ko04721	Synaptic vesicle cycle	41/955	80/7206	2.83063019695e-16
ko04020	Calcium signaling pathway	80/955	265/7206	1.80399273498e-13
ko04921	Oxytocin signaling pathway	68/955	209/7206	3.08128696889e-13
ko05031	Amphetamine addiction	40/955	91/7206	4.55525379306e-13
ko04726	Serotonergic synapse	51/955	137/7206	7.79348279833e-13
ko04261	Adrenergic signaling in cardiomyocytes	66/955	205/7206	1.05598023853e-12
ko04742	Taste transduction	31/955	61/7206	1.72604335063e-12
ko04744	Phototransduction	23/955	36/7206	2.12371906354e-12
ko05030	Cocaine addiction	34/955	73/7206	3.52964533085e-12
ko04720	Long-term potentiation	40/955	99/7206	1.21075879274e-11
ko04970	Salivary secretion	39/955	95/7206	1.21858858501e-11
ko04010	MAPK signaling pathway	83/955	321/7206	6.16285808078e-10
ko04925	Aldosterone synthesis and secretion	38/955	105/7206	1.74831239719e-09
ko04972	Pancreatic secretion	39/955	111/7206	2.86226965037e-09
ko04971	Gastric acid secretion	36/955	98/7206	2.94442275426e-09
ko03040	Spliceosome	1/955	145/7206	3.63212850892e-08
ko04072	Phospholipase D signaling pathway	54/955	197/7206	8.73290341443e-08
ko04360	Axon guidance	58/955	233/7206	1.02684498273e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/955	74/7206	1.26871551821e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/955	59/7206	2.67423389193e-06
ko05203	Viral carcinogenesis	13/955	277/7206	3.01923154948e-06
ko04730	Long-term depression	26/955	78/7206	3.93927638949e-06
ko04740	Olfactory transduction	26/955	80/7206	6.67891242811e-06
ko04060	Cytokine-cytokine receptor interaction	7/955	191/7206	1.09648298116e-05
ko04915	Estrogen signaling pathway	36/955	131/7206	1.15349962986e-05
ko05414	Dilated cardiomyopathy	32/955	112/7206	1.49306787321e-05
ko04022	cGMP-PKG signaling pathway	51/955	216/7206	2.39634522414e-05
ko03013	RNA transport	6/955	166/7206	3.87640724159e-05
ko05322	Systemic lupus erythematosus	5/955	151/7206	4.77894176991e-05
ko04540	Gap junction	34/955	128/7206	5.38215516585e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/955	79/7206	6.4871387782e-05
ko04514	Cell adhesion molecules (CAMs)	34/955	130/7206	6.59829933653e-05
ko04918	Thyroid hormone synthesis	25/955	86/7206	8.7319961806e-05
ko04070	Phosphatidylinositol signaling system	30/955	112/7206	0.000108703427027
ko04923	Regulation of lipolysis in adipocytes	23/955	77/7206	0.000116471338331
ko04260	Cardiac muscle contraction	27/955	98/7206	0.000133382591852
ko04976	Bile secretion	23/955	80/7206	0.000200087895681
ko04750	Inflammatory mediator regulation of TRP channels	31/955	122/7206	0.00023312576485
ko04371	Apelin signaling pathway	41/955	177/7206	0.000275662374613
ko05168	Herpes simplex infection	9/955	182/7206	0.000338434653654
ko04014	Ras signaling pathway	58/955	279/7206	0.000401015655148
ko04015	Rap1 signaling pathway	57/955	278/7206	0.000568646113964
ko04350	TGF-beta signaling pathway	3/955	103/7206	0.000608939711134
ko04745	Phototransduction - fly	13/955	38/7206	0.000789259559666
ko04932	Non-alcoholic fatty liver disease (NAFLD)	10/955	182/7206	0.000824614622554
ko04141	Protein processing in endoplasmic reticulum	10/955	184/7206	0.000842309420034
ko03018	RNA degradation	2/955	84/7206	0.00100343578456
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/955	14/7206	0.00103190935314
ko05164	Influenza A	9/955	167/7206	0.00114960758126
ko04110	Cell cycle	7/955	145/7206	0.00117366093583
ko04621	NOD-like receptor signaling pathway	8/955	157/7206	0.00117673299101
ko04062	Chemokine signaling pathway	43/955	201/7206	0.00140115307683
ko04612	Antigen processing and presentation	2/955	77/7206	0.00214093780386
ko03008	Ribosome biogenesis in eukaryotes	2/955	79/7206	0.00218586543732
ko04120	Ubiquitin mediated proteolysis	7/955	138/7206	0.00220672592525
ko04973	Carbohydrate digestion and absorption	13/955	42/7206	0.00223911283273
ko04640	Hematopoietic cell lineage	1/955	64/7206	0.00238455063975
ko05034	Alcoholism	48/955	238/7206	0.00243800125463
ko04912	GnRH signaling pathway	28/955	122/7206	0.0028162767848
ko00515	Mannose type O-glycan biosynthesis	9/955	25/7206	0.00340012743352
ko04916	Melanogenesis	31/955	142/7206	0.00388684837125
ko00240	Pyrimidine metabolism	5/955	110/7206	0.00416996801087
ko05321	Inflammatory bowel disease (IBD)	1/955	56/7206	0.00512176046927
ko04924	Renin secretion	21/955	86/7206	0.00562468852019
ko05231	Choline metabolism in cancer	29/955	134/7206	0.00648673858054
ko00480	Glutathione metabolism	1/955	55/7206	0.00788793284605
ko05110	Vibrio cholerae infection	16/955	63/7206	0.00805835921979
ko04960	Aldosterone-regulated sodium reabsorption	12/955	41/7206	0.00832427842688
ko04213	Longevity regulating pathway - multiple species	20/955	86/7206	0.00977366310993
ko00512	Mucin type O-glycan biosynthesis	9/955	29/7206	0.0102145941561
ko04964	Proximal tubule bicarbonate reclamation	9/955	29/7206	0.0102145941561
ko04146	Peroxisome	4/955	89/7206	0.0109640465964
ko04930	Type II diabetes mellitus	14/955	54/7206	0.0132072791089
ko05162	Measles	7/955	120/7206	0.013741362821
ko04064	NF-kappa B signaling pathway	5/955	96/7206	0.0148949246604
ko05140	Leishmaniasis	3/955	75/7206	0.0150857927954
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/955	26/7206	0.0160026313119
ko05169	Epstein-Barr virus infection	16/955	206/7206	0.0162340798702
ko00270	Cysteine and methionine metabolism	1/955	47/7206	0.0166491860117
ko00260	Glycine, serine and threonine metabolism	1/955	48/7206	0.016843212268
ko05145	Toxoplasmosis	8/955	126/7206	0.0169195077826
ko05205	Proteoglycans in cancer	23/955	271/7206	0.0172755847818
ko04722	Neurotrophin signaling pathway	32/955	160/7206	0.0175483399274
ko05016	Huntington's disease	17/955	215/7206	0.0183494775085
ko04962	Vasopressin-regulated water reabsorption	14/955	58/7206	0.0195538277881
ko00330	Arginine and proline metabolism	2/955	61/7206	0.0204990932929
ko04711	Circadian rhythm - fly	5/955	13/7206	0.020793051554
ko04214	Apoptosis - fly	3/955	72/7206	0.0213040421817
ko04666	Fc gamma R-mediated phagocytosis	25/955	122/7206	0.0218327423857
ko03022	Basal transcription factors	1/955	44/7206	0.0245867823409
ko04216	Ferroptosis	1/955	44/7206	0.0245867823409
ko00071	Fatty acid degradation	1/955	45/7206	0.0249218965658
ko00620	Pyruvate metabolism	1/955	46/7206	0.0257525018787
ko03420	Nucleotide excision repair	1/955	46/7206	0.0257525018787
ko05410	Hypertrophic cardiomyopathy (HCM)	21/955	100/7206	0.0259662837971
ko04142	Lysosome	11/955	151/7206	0.0283124944269
ko04217	Necroptosis	14/955	178/7206	0.0327336785698
ko04071	Sphingolipid signaling pathway	31/955	162/7206	0.0339414872159
ko01200	Carbon metabolism	9/955	128/7206	0.0348203265463
ko00190	Oxidative phosphorylation	9/955	127/7206	0.0348343118029
ko05133	Pertussis	5/955	87/7206	0.0374733767682
ko00280	Valine, leucine and isoleucine degradation	2/955	54/7206	0.0409509241776
ko04144	Endocytosis	58/955	342/7206	0.0411414691141
ko04914	Progesterone-mediated oocyte maturation	21/955	104/7206	0.0411909587362
ko04114	Oocyte meiosis	27/955	139/7206	0.0419405080551
ko05214	Glioma	17/955	79/7206	0.0428701755819