ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	194/1177	423/7206	1.80378965338e-49
ko04724	Glutamatergic synapse	84/1177	152/7206	1.31155926979e-28
ko05033	Nicotine addiction	46/1177	56/7206	1.992266677e-27
ko05032	Morphine addiction	65/1177	110/7206	1.38089694037e-24
ko04713	Circadian entrainment	72/1177	136/7206	3.82667169009e-23
ko04721	Synaptic vesicle cycle	52/1177	80/7206	1.22450243798e-22
ko04727	GABAergic synapse	61/1177	110/7206	3.75177185698e-21
ko04728	Dopaminergic synapse	80/1177	185/7206	1.60320607677e-18
ko04725	Cholinergic synapse	72/1177	160/7206	6.11383417193e-18
ko04024	cAMP signaling pathway	100/1177	279/7206	5.43513815187e-16
ko04020	Calcium signaling pathway	96/1177	265/7206	1.33967935564e-15
ko04723	Retrograde endocannabinoid signaling	72/1177	175/7206	2.21732748955e-15
ko04742	Taste transduction	37/1177	61/7206	4.97312504896e-15
ko04726	Serotonergic synapse	58/1177	137/7206	2.91164768034e-13
ko04921	Oxytocin signaling pathway	76/1177	209/7206	1.317230853e-12
ko04911	Insulin secretion	51/1177	117/7206	2.10938323166e-12
ko04261	Adrenergic signaling in cardiomyocytes	70/1177	205/7206	2.72401444146e-10
ko04970	Salivary secretion	41/1177	95/7206	4.5830619541e-10
ko03040	Spliceosome	2/1177	145/7206	4.10643688779e-09
ko05031	Amphetamine addiction	38/1177	91/7206	6.13609277791e-09
ko04360	Axon guidance	73/1177	233/7206	7.45259272958e-09
ko04720	Long-term potentiation	40/1177	99/7206	7.68714681549e-09
ko04744	Phototransduction	21/1177	36/7206	1.1781053805e-08
ko04966	Collecting duct acid secretion	17/1177	26/7206	2.69142937689e-08
ko05203	Viral carcinogenesis	16/1177	277/7206	1.18489703609e-07
ko05168	Herpes simplex infection	7/1177	182/7206	2.14039472965e-07
ko04740	Olfactory transduction	32/1177	80/7206	3.20187920644e-07
ko05322	Systemic lupus erythematosus	5/1177	151/7206	5.81162516388e-07
ko04120	Ubiquitin mediated proteolysis	4/1177	138/7206	6.34383280845e-07
ko04925	Aldosterone synthesis and secretion	38/1177	105/7206	6.87146292652e-07
ko04022	cGMP-PKG signaling pathway	64/1177	216/7206	7.89310702831e-07
ko04060	Cytokine-cytokine receptor interaction	9/1177	191/7206	8.29649690924e-07
ko05164	Influenza A	7/1177	167/7206	1.2983648025e-06
ko03013	RNA transport	7/1177	166/7206	1.90723768401e-06
ko04924	Renin secretion	32/1177	86/7206	2.33392787411e-06
ko04971	Gastric acid secretion	35/1177	98/7206	2.64462254961e-06
ko05030	Cocaine addiction	28/1177	73/7206	6.6994059953e-06
ko04540	Gap junction	41/1177	128/7206	9.26436965421e-06
ko04514	Cell adhesion molecules (CAMs)	41/1177	130/7206	1.87268399946e-05
ko04610	Complement and coagulation cascades	1/1177	79/7206	2.0317451411e-05
ko04260	Cardiac muscle contraction	33/1177	98/7206	2.24692366621e-05
ko04621	NOD-like receptor signaling pathway	8/1177	157/7206	2.53924515192e-05
ko04110	Cell cycle	7/1177	145/7206	3.30871855467e-05
ko04010	MAPK signaling pathway	80/1177	321/7206	5.33773449709e-05
ko04014	Ras signaling pathway	71/1177	279/7206	6.70418347501e-05
ko04730	Long-term depression	27/1177	78/7206	7.26424111269e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1177	74/7206	8.71429289061e-05
ko04745	Phototransduction - fly	16/1177	38/7206	0.00014274588145
ko04972	Pancreatic secretion	34/1177	111/7206	0.000142922038351
ko05169	Epstein-Barr virus infection	15/1177	206/7206	0.000166603233172
ko03008	Ribosome biogenesis in eukaryotes	2/1177	79/7206	0.000171659902552
ko05205	Proteoglycans in cancer	23/1177	271/7206	0.000205976932639
ko04141	Protein processing in endoplasmic reticulum	13/1177	184/7206	0.000244452729941
ko04612	Antigen processing and presentation	2/1177	77/7206	0.000259627726086
ko05140	Leishmaniasis	2/1177	75/7206	0.000395931088136
ko04214	Apoptosis - fly	2/1177	72/7206	0.000572785793122
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1177	79/7206	0.000628994393859
ko05162	Measles	7/1177	120/7206	0.000703298764986
ko05161	Hepatitis B	13/1177	173/7206	0.000795741881933
ko05110	Vibrio cholerae infection	21/1177	63/7206	0.000847513354899
ko05166	HTLV-I infection	28/1177	292/7206	0.000894950357711
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1177	59/7206	0.00103519680378
ko04976	Bile secretion	25/1177	80/7206	0.00110998895993
ko04964	Proximal tubule bicarbonate reclamation	12/1177	29/7206	0.00116709670258
ko04064	NF-kappa B signaling pathway	5/1177	96/7206	0.00128590018695
ko00520	Amino sugar and nucleotide sugar metabolism	1/1177	55/7206	0.0013609955456
ko00480	Glutathione metabolism	1/1177	55/7206	0.0013609955456
ko04371	Apelin signaling pathway	45/1177	177/7206	0.00185453225107
ko00240	Pyrimidine metabolism	7/1177	110/7206	0.0025771359618
ko05414	Dilated cardiomyopathy	31/1177	112/7206	0.00270010463155
ko04750	Inflammatory mediator regulation of TRP channels	33/1177	122/7206	0.00272068278777
ko04923	Regulation of lipolysis in adipocytes	23/1177	77/7206	0.00278344779473
ko04146	Peroxisome	5/1177	89/7206	0.0035691674094
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1177	14/7206	0.00361649239703
ko03420	Nucleotide excision repair	1/1177	46/7206	0.00441791477948
ko04626	Plant-pathogen interaction	8/1177	18/7206	0.00464536771619
ko04657	IL-17 signaling pathway	5/1177	87/7206	0.00503290087331
ko04922	Glucagon signaling pathway	33/1177	128/7206	0.00534674395743
ko05321	Inflammatory bowel disease (IBD)	2/1177	56/7206	0.00571529298806
ko05215	Prostate cancer	8/1177	111/7206	0.00627940836146
ko03022	Basal transcription factors	1/1177	44/7206	0.00668894044395
ko01524	Platinum drug resistance	4/1177	76/7206	0.00710890695325
ko04915	Estrogen signaling pathway	33/1177	131/7206	0.00834919161558
ko04330	Notch signaling pathway	3/1177	62/7206	0.00923454903633
ko04622	RIG-I-like receptor signaling pathway	3/1177	62/7206	0.00923454903633
ko04640	Hematopoietic cell lineage	3/1177	64/7206	0.0095996163958
ko05131	Shigellosis	5/1177	82/7206	0.00978146702001
ko00310	Lysine degradation	4/1177	73/7206	0.00985629864885
ko04630	Jak-STAT signaling pathway	11/1177	132/7206	0.0119325471535
ko00380	Tryptophan metabolism	2/1177	50/7206	0.0121079992502
ko04658	Th1 and Th2 cell differentiation	7/1177	96/7206	0.0121417357921
ko00590	Arachidonic acid metabolism	2/1177	52/7206	0.0126202596703
ko05133	Pertussis	6/1177	87/7206	0.0128114994415
ko04217	Necroptosis	17/1177	178/7206	0.0132534744452
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1177	100/7206	0.0133767107119
ko04072	Phospholipase D signaling pathway	45/1177	197/7206	0.0145677758403
ko03410	Base excision repair	1/1177	38/7206	0.0148791725044
ko05219	Bladder cancer	2/1177	48/7206	0.0176016141377
ko04070	Phosphatidylinositol signaling system	28/1177	112/7206	0.0194266155846
ko05145	Toxoplasmosis	11/1177	126/7206	0.0201018728243
ko04620	Toll-like receptor signaling pathway	8/1177	100/7206	0.0202214296738
ko05212	Pancreatic cancer	6/1177	83/7206	0.0238869518184
ko00071	Fatty acid degradation	2/1177	45/7206	0.025434726137
ko04115	p53 signaling pathway	5/1177	74/7206	0.0254622053222
ko00280	Valine, leucine and isoleucine degradation	3/1177	54/7206	0.0264623290671
ko05222	Small cell lung cancer	7/1177	89/7206	0.0294733180324
ko04350	TGF-beta signaling pathway	9/1177	103/7206	0.0319722681154
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1177	92/7206	0.0320452617749
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1177	182/7206	0.032265844681
ko00330	Arginine and proline metabolism	4/1177	61/7206	0.0361817444402
ko00010	Glycolysis / Gluconeogenesis	19/1177	74/7206	0.0384119347196
ko05220	Chronic myeloid leukemia	7/1177	85/7206	0.0390488508797
ko04930	Type II diabetes mellitus	15/1177	54/7206	0.0392567319611
ko05206	MicroRNAs in cancer	19/1177	177/7206	0.0395910506611
ko00512	Mucin type O-glycan biosynthesis	9/1177	29/7206	0.0421358941022
ko05217	Basal cell carcinoma	5/1177	68/7206	0.046656088439