ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	36/540	56/7206	1.94280169458e-27
ko04080	Neuroactive ligand-receptor interaction	100/540	423/7206	3.73896410996e-27
ko04724	Glutamatergic synapse	56/540	152/7206	1.50334714395e-25
ko04728	Dopaminergic synapse	55/540	185/7206	5.51082530088e-20
ko04727	GABAergic synapse	41/540	110/7206	3.64845408732e-19
ko05032	Morphine addiction	40/540	110/7206	2.83595016741e-18
ko04721	Synaptic vesicle cycle	33/540	80/7206	3.26529335485e-17
ko04723	Retrograde endocannabinoid signaling	49/540	175/7206	1.03090784728e-16
ko04713	Circadian entrainment	40/540	136/7206	1.24539725274e-14
ko04725	Cholinergic synapse	39/540	160/7206	1.88171999764e-11
ko04024	cAMP signaling pathway	53/540	279/7206	1.30470676299e-10
ko05014	Amyotrophic lateral sclerosis (ALS)	23/540	74/7206	1.82299420087e-09
ko04261	Adrenergic signaling in cardiomyocytes	41/540	205/7206	3.78254815189e-09
ko05031	Amphetamine addiction	25/540	91/7206	6.25683475601e-09
ko05030	Cocaine addiction	22/540	73/7206	7.87113177426e-09
ko04726	Serotonergic synapse	31/540	137/7206	1.59177572472e-08
ko04514	Cell adhesion molecules (CAMs)	29/540	130/7206	6.52208070952e-08
ko04911	Insulin secretion	27/540	117/7206	8.85954942276e-08
ko04742	Taste transduction	17/540	61/7206	1.3834068276e-06
ko04921	Oxytocin signaling pathway	36/540	209/7206	1.72396728488e-06
ko04010	MAPK signaling pathway	48/540	321/7206	3.37293090118e-06
ko04720	Long-term potentiation	20/540	99/7206	3.46794820499e-05
ko05203	Viral carcinogenesis	6/540	277/7206	0.000158835097412
ko04730	Long-term depression	16/540	78/7206	0.000172806983962
ko04360	Axon guidance	34/540	233/7206	0.000186202772836
ko04020	Calcium signaling pathway	37/540	265/7206	0.000189520983356
ko04970	Salivary secretion	18/540	95/7206	0.000200782020794
ko04260	Cardiac muscle contraction	18/540	98/7206	0.000300899984593
ko03040	Spliceosome	1/540	145/7206	0.000316703204925
ko04060	Cytokine-cytokine receptor interaction	3/540	191/7206	0.000408062696534
ko04966	Collecting duct acid secretion	8/540	26/7206	0.000439532431467
ko04120	Ubiquitin mediated proteolysis	1/540	138/7206	0.00045090326081
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	15/540	79/7206	0.000655488875748
ko04972	Pancreatic secretion	19/540	111/7206	0.000688315180002
ko05205	Proteoglycans in cancer	8/540	271/7206	0.0020503711788
ko03013	RNA transport	3/540	166/7206	0.00241994951153
ko05164	Influenza A	3/540	167/7206	0.00246777543754
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/540	14/7206	0.00262769746527
ko05168	Herpes simplex infection	4/540	182/7206	0.00379052353304
ko05322	Systemic lupus erythematosus	3/540	151/7206	0.00466141389044
ko05414	Dilated cardiomyopathy	17/540	112/7206	0.00539270360157
ko05146	Amoebiasis	1/540	99/7206	0.00648924039252
ko05110	Vibrio cholerae infection	11/540	63/7206	0.00651567755936
ko04014	Ras signaling pathway	33/540	279/7206	0.00747558621882
ko04022	cGMP-PKG signaling pathway	27/540	216/7206	0.00807123214477
ko05162	Measles	2/540	120/7206	0.0081678642282
ko05034	Alcoholism	29/540	238/7206	0.00819469815949
ko04915	Estrogen signaling pathway	18/540	131/7206	0.0109413555333
ko04961	Endocrine and other factor-regulated calcium reabsorption	10/540	59/7206	0.0114314177854
ko04621	NOD-like receptor signaling pathway	4/540	157/7206	0.0132719031178
ko00240	Pyrimidine metabolism	2/540	110/7206	0.0165156641918
ko04540	Gap junction	17/540	128/7206	0.0173179068468
ko04072	Phospholipase D signaling pathway	24/540	197/7206	0.0184628684343
ko04964	Proximal tubule bicarbonate reclamation	6/540	29/7206	0.0185477893038
ko05410	Hypertrophic cardiomyopathy (HCM)	14/540	100/7206	0.0200806320278
ko05010	Alzheimer's disease	24/540	202/7206	0.0209463879091
ko02024	Quorum sensing	4/540	15/7206	0.0218870571475
ko04350	TGF-beta signaling pathway	2/540	103/7206	0.0232748865462
ko04611	Platelet activation	5/540	163/7206	0.0239016100834
ko04068	FoxO signaling pathway	5/540	167/7206	0.0242738710383
ko05120	Epithelial cell signaling in Helicobacter pylori infection	13/540	92/7206	0.0252966846415
ko04612	Antigen processing and presentation	1/540	77/7206	0.0290103657238
ko03008	Ribosome biogenesis in eukaryotes	1/540	79/7206	0.0292687203507
ko04940	Type I diabetes mellitus	6/540	32/7206	0.0292724230448
ko04924	Renin secretion	12/540	86/7206	0.0354139352993
ko04962	Vasopressin-regulated water reabsorption	9/540	58/7206	0.0380799471072
ko05161	Hepatitis B	6/540	173/7206	0.0399201176688
ko04214	Apoptosis - fly	1/540	72/7206	0.0419768911409
ko05169	Epstein-Barr virus infection	8/540	206/7206	0.043663474297
ko04510	Focal adhesion	10/540	240/7206	0.0455620439077
ko04145	Phagosome	19/540	162/7206	0.0481504138107