ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	219/1297	423/7206	4.72293437563e-60
ko04724	Glutamatergic synapse	93/1297	152/7206	5.34601070698e-33
ko05033	Nicotine addiction	50/1297	56/7206	2.77962660188e-31
ko04713	Circadian entrainment	84/1297	136/7206	2.6303043712e-30
ko05032	Morphine addiction	73/1297	110/7206	2.0938376707e-29
ko04727	GABAergic synapse	70/1297	110/7206	1.46951187438e-26
ko04728	Dopaminergic synapse	90/1297	185/7206	4.47873269153e-22
ko04725	Cholinergic synapse	80/1297	160/7206	1.11531059586e-20
ko04721	Synaptic vesicle cycle	52/1297	80/7206	1.22497366548e-20
ko04020	Calcium signaling pathway	110/1297	265/7206	8.01258688004e-20
ko04723	Retrograde endocannabinoid signaling	82/1297	175/7206	6.51401898506e-19
ko04024	cAMP signaling pathway	112/1297	279/7206	9.09718796742e-19
ko04911	Insulin secretion	63/1297	117/7206	1.23112984926e-18
ko04726	Serotonergic synapse	65/1297	137/7206	1.45670764178e-15
ko04742	Taste transduction	39/1297	61/7206	1.99769214692e-15
ko04921	Oxytocin signaling pathway	85/1297	209/7206	6.53583743438e-15
ko04744	Phototransduction	27/1297	36/7206	1.09055166399e-13
ko04970	Salivary secretion	48/1297	95/7206	4.12269809986e-13
ko05031	Amphetamine addiction	46/1297	91/7206	1.2531407124e-12
ko04261	Adrenergic signaling in cardiomyocytes	78/1297	205/7206	7.14975396404e-12
ko04720	Long-term potentiation	47/1297	99/7206	1.28264694899e-11
ko03040	Spliceosome	1/1297	145/7206	1.58845413268e-11
ko05203	Viral carcinogenesis	15/1297	277/7206	4.55308937827e-10
ko04740	Olfactory transduction	38/1297	80/7206	1.1765099176e-09
ko04925	Aldosterone synthesis and secretion	45/1297	105/7206	3.0240597919e-09
ko04060	Cytokine-cytokine receptor interaction	8/1297	191/7206	9.56535291755e-09
ko04971	Gastric acid secretion	42/1297	98/7206	1.08853679823e-08
ko05168	Herpes simplex infection	8/1297	182/7206	4.3329044833e-08
ko05322	Systemic lupus erythematosus	5/1297	151/7206	4.38932153611e-08
ko05030	Cocaine addiction	33/1297	73/7206	6.65898491915e-08
ko03013	RNA transport	7/1297	166/7206	1.10373082496e-07
ko04022	cGMP-PKG signaling pathway	71/1297	216/7206	1.1192138845e-07
ko04360	Axon guidance	75/1297	233/7206	1.26620928217e-07
ko04070	Phosphatidylinositol signaling system	43/1297	112/7206	3.03098745826e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1297	74/7206	1.68997300922e-06
ko04730	Long-term depression	32/1297	78/7206	1.70863623174e-06
ko05164	Influenza A	9/1297	167/7206	1.95082414226e-06
ko04010	MAPK signaling pathway	91/1297	321/7206	3.36465636456e-06
ko04540	Gap junction	45/1297	128/7206	3.58993753615e-06
ko04972	Pancreatic secretion	40/1297	111/7206	4.75974570762e-06
ko04966	Collecting duct acid secretion	15/1297	26/7206	6.56768152512e-06
ko04924	Renin secretion	33/1297	86/7206	6.79047929205e-06
ko04621	NOD-like receptor signaling pathway	9/1297	157/7206	8.00610071354e-06
ko04141	Protein processing in endoplasmic reticulum	13/1297	184/7206	2.40118159968e-05
ko04514	Cell adhesion molecules (CAMs)	43/1297	130/7206	2.66259342553e-05
ko04072	Phospholipase D signaling pathway	59/1297	197/7206	3.03142878808e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1297	79/7206	4.44693439189e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1297	79/7206	8.19891902272e-05
ko04976	Bile secretion	29/1297	80/7206	9.56134275474e-05
ko05169	Epstein-Barr virus infection	17/1297	206/7206	9.60591709097e-05
ko05414	Dilated cardiomyopathy	37/1297	112/7206	0.000100664078351
ko04120	Ubiquitin mediated proteolysis	9/1297	138/7206	0.000122413517403
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1297	59/7206	0.000123635465057
ko04745	Phototransduction - fly	17/1297	38/7206	0.000123693500895
ko04923	Regulation of lipolysis in adipocytes	28/1297	77/7206	0.000128020637306
ko04260	Cardiac muscle contraction	33/1297	98/7206	0.000165442075057
ko04110	Cell cycle	10/1297	145/7206	0.000172214454379
ko05110	Vibrio cholerae infection	24/1297	63/7206	0.000179299280463
ko04750	Inflammatory mediator regulation of TRP channels	39/1297	122/7206	0.000182729068367
ko05205	Proteoglycans in cancer	27/1297	271/7206	0.00026399078001
ko04610	Complement and coagulation cascades	3/1297	79/7206	0.000303262750839
ko04014	Ras signaling pathway	74/1297	279/7206	0.000322799199582
ko04612	Antigen processing and presentation	3/1297	77/7206	0.000453439179048
ko05162	Measles	8/1297	120/7206	0.000455470413521
ko00240	Pyrimidine metabolism	7/1297	110/7206	0.000630958595874
ko04371	Apelin signaling pathway	50/1297	177/7206	0.000688905969187
ko04657	IL-17 signaling pathway	5/1297	87/7206	0.00170349526825
ko03420	Nucleotide excision repair	1/1297	46/7206	0.00177150356609
ko05166	HTLV-I infection	33/1297	292/7206	0.00180110626735
ko05140	Leishmaniasis	4/1297	75/7206	0.00219903508584
ko03018	RNA degradation	5/1297	84/7206	0.00235253040017
ko00520	Amino sugar and nucleotide sugar metabolism	2/1297	55/7206	0.0024083136706
ko00480	Glutathione metabolism	2/1297	55/7206	0.0024083136706
ko05321	Inflammatory bowel disease (IBD)	2/1297	56/7206	0.00245016609028
ko04918	Thyroid hormone synthesis	27/1297	86/7206	0.00262329014134
ko03022	Basal transcription factors	1/1297	44/7206	0.00267876624639
ko05144	Malaria	1/1297	45/7206	0.00274319715451
ko00071	Fatty acid degradation	1/1297	45/7206	0.00274319715451
ko04964	Proximal tubule bicarbonate reclamation	12/1297	29/7206	0.00277768827971
ko04146	Peroxisome	6/1297	89/7206	0.00329224783443
ko04270	Vascular smooth muscle contraction	42/1297	154/7206	0.00398270864598
ko04217	Necroptosis	18/1297	178/7206	0.00406705819646
ko04622	RIG-I-like receptor signaling pathway	3/1297	62/7206	0.00416953634675
ko04658	Th1 and Th2 cell differentiation	7/1297	96/7206	0.00452763167857
ko04064	NF-kappa B signaling pathway	7/1297	96/7206	0.00452763167857
ko05133	Pertussis	6/1297	87/7206	0.00458784545319
ko00562	Inositol phosphate metabolism	27/1297	89/7206	0.0049157322371
ko04630	Jak-STAT signaling pathway	12/1297	132/7206	0.00575116587517
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1297	100/7206	0.00579176142206
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1297	14/7206	0.00635472667676
ko05161	Hepatitis B	18/1297	173/7206	0.00670743805351
ko04915	Estrogen signaling pathway	36/1297	131/7206	0.00781120072214
ko04626	Plant-pathogen interaction	8/1297	18/7206	0.00853840150226
ko05131	Shigellosis	6/1297	82/7206	0.00874297434826
ko00310	Lysine degradation	5/1297	73/7206	0.00896372424442
ko04115	p53 signaling pathway	5/1297	74/7206	0.00901363767142
ko05145	Toxoplasmosis	12/1297	126/7206	0.00990271303951
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1297	182/7206	0.0108908716958
ko05215	Prostate cancer	10/1297	111/7206	0.0121342756093
ko04912	GnRH signaling pathway	33/1297	122/7206	0.0121417095387
ko00280	Valine, leucine and isoleucine degradation	3/1297	54/7206	0.0123105882613
ko04214	Apoptosis - fly	5/1297	72/7206	0.0126347643327
ko04973	Carbohydrate digestion and absorption	14/1297	42/7206	0.0146672296216
ko05231	Choline metabolism in cancer	35/1297	134/7206	0.0169252500249
ko03320	PPAR signaling pathway	5/1297	69/7206	0.0172911970462
ko04620	Toll-like receptor signaling pathway	9/1297	100/7206	0.0175538398726
ko00590	Arachidonic acid metabolism	3/1297	52/7206	0.0176038473929
ko00330	Arginine and proline metabolism	4/1297	61/7206	0.0178802286004
ko00290	Valine, leucine and isoleucine biosynthesis	3/1297	4/7206	0.0201428845092
ko04015	Rap1 signaling pathway	65/1297	278/7206	0.0207281579109
ko04978	Mineral absorption	13/1297	40/7206	0.0227530235946
ko05132	Salmonella infection	9/1297	98/7206	0.0233998092072
ko05016	Huntington's disease	26/1297	215/7206	0.0237934216973
ko04922	Glucagon signaling pathway	33/1297	128/7206	0.0267703848856
ko04916	Melanogenesis	36/1297	142/7206	0.0268153482027
ko04350	TGF-beta signaling pathway	10/1297	103/7206	0.0273552065139
ko04140	Autophagy - animal	19/1297	164/7206	0.0304812590996
ko04142	Lysosome	17/1297	151/7206	0.0315887905949
ko04930	Type II diabetes mellitus	16/1297	54/7206	0.0322675488551
ko00600	Sphingolipid metabolism	5/1297	63/7206	0.0326130037456
ko04640	Hematopoietic cell lineage	5/1297	64/7206	0.0326194317611
ko05219	Bladder cancer	3/1297	48/7206	0.035975508134
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1297	40/7206	0.0360183606544
ko04960	Aldosterone-regulated sodium reabsorption	13/1297	41/7206	0.0380653849609
ko04210	Apoptosis	22/1297	180/7206	0.0392552647937
ko04659	Th17 cell differentiation	11/1297	106/7206	0.0409295314529
ko04113	Meiosis - yeast	6/1297	70/7206	0.0409823320115
ko05418	Fluid shear stress and atherosclerosis	21/1297	173/7206	0.0446721564055
ko04330	Notch signaling pathway	5/1297	62/7206	0.0447589451794
ko05320	Autoimmune thyroid disease	1/1297	29/7206	0.0484380261271