ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1176	423/7206	1.50664253534e-54
ko04724	Glutamatergic synapse	90/1176	152/7206	7.8297325176e-34
ko05033	Nicotine addiction	49/1176	56/7206	8.11446873136e-32
ko04713	Circadian entrainment	78/1176	136/7206	4.05247534974e-28
ko05032	Morphine addiction	67/1176	110/7206	2.00354776788e-26
ko04727	GABAergic synapse	66/1176	110/7206	1.65414564618e-25
ko04721	Synaptic vesicle cycle	53/1176	80/7206	1.15616974142e-23
ko04728	Dopaminergic synapse	85/1176	185/7206	9.26994504212e-22
ko04725	Cholinergic synapse	77/1176	160/7206	2.44233514124e-21
ko04024	cAMP signaling pathway	108/1176	279/7206	4.11807473213e-20
ko04723	Retrograde endocannabinoid signaling	78/1176	175/7206	4.6200899351e-19
ko04742	Taste transduction	40/1176	61/7206	6.56332385765e-18
ko04911	Insulin secretion	59/1176	117/7206	7.63554391155e-18
ko04020	Calcium signaling pathway	100/1176	265/7206	9.82374191529e-18
ko04726	Serotonergic synapse	63/1176	137/7206	1.98804144463e-16
ko04921	Oxytocin signaling pathway	81/1176	209/7206	2.19448834115e-15
ko04744	Phototransduction	27/1176	36/7206	8.96823284427e-15
ko04740	Olfactory transduction	43/1176	80/7206	1.25461717688e-14
ko04720	Long-term potentiation	48/1176	99/7206	6.64799235411e-14
ko05031	Amphetamine addiction	43/1176	91/7206	4.13591572581e-12
ko04970	Salivary secretion	43/1176	95/7206	2.48290277795e-11
ko04261	Adrenergic signaling in cardiomyocytes	71/1176	205/7206	7.49114446027e-11
ko03040	Spliceosome	1/1176	145/7206	1.96335709212e-10
ko04925	Aldosterone synthesis and secretion	42/1176	105/7206	4.5218960327e-09
ko04971	Gastric acid secretion	40/1176	98/7206	5.28444313765e-09
ko05168	Herpes simplex infection	5/1176	182/7206	5.41748737696e-09
ko05203	Viral carcinogenesis	14/1176	277/7206	9.90820581895e-09
ko05030	Cocaine addiction	31/1176	73/7206	9.51531995478e-08
ko04360	Axon guidance	70/1176	233/7206	1.08194026752e-07
ko04060	Cytokine-cytokine receptor interaction	8/1176	191/7206	2.49315316725e-07
ko04120	Ubiquitin mediated proteolysis	4/1176	138/7206	9.95104030163e-07
ko05164	Influenza A	7/1176	167/7206	1.30278648127e-06
ko04540	Gap junction	43/1176	128/7206	1.34164463176e-06
ko04022	cGMP-PKG signaling pathway	63/1176	216/7206	1.40855920281e-06
ko04966	Collecting duct acid secretion	15/1176	26/7206	1.83913711392e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1176	74/7206	1.84595103101e-06
ko03013	RNA transport	7/1176	166/7206	1.90171697425e-06
ko04972	Pancreatic secretion	38/1176	111/7206	3.18517602271e-06
ko04621	NOD-like receptor signaling pathway	7/1176	157/7206	5.5372045917e-06
ko04260	Cardiac muscle contraction	34/1176	98/7206	6.71761009291e-06
ko04730	Long-term depression	29/1176	78/7206	7.23064601931e-06
ko04745	Phototransduction - fly	18/1176	38/7206	7.50206466463e-06
ko04924	Renin secretion	31/1176	86/7206	1.01203662087e-05
ko04141	Protein processing in endoplasmic reticulum	10/1176	184/7206	1.03656072791e-05
ko05322	Systemic lupus erythematosus	7/1176	151/7206	1.6764937198e-05
ko04010	MAPK signaling pathway	82/1176	321/7206	1.83886524273e-05
ko04610	Complement and coagulation cascades	1/1176	79/7206	2.03135876694e-05
ko05169	Epstein-Barr virus infection	13/1176	206/7206	2.06880456344e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1176	59/7206	2.36141321636e-05
ko04514	Cell adhesion molecules (CAMs)	40/1176	130/7206	3.44276326747e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1176	79/7206	3.76986790788e-05
ko04976	Bile secretion	28/1176	80/7206	4.37271863435e-05
ko05162	Measles	5/1176	120/7206	5.2242506197e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1176	29/7206	6.03264099556e-05
ko05110	Vibrio cholerae infection	23/1176	63/7206	9.21752012037e-05
ko04110	Cell cycle	8/1176	145/7206	9.83372896994e-05
ko04750	Inflammatory mediator regulation of TRP channels	37/1176	122/7206	9.87666968818e-05
ko04626	Plant-pathogen interaction	10/1176	18/7206	0.000159772616977
ko03008	Ribosome biogenesis in eukaryotes	2/1176	79/7206	0.000171614078537
ko05414	Dilated cardiomyopathy	34/1176	112/7206	0.000237865298937
ko04612	Antigen processing and presentation	2/1176	77/7206	0.000259232894354
ko05140	Leishmaniasis	2/1176	75/7206	0.000394884349846
ko04064	NF-kappa B signaling pathway	4/1176	96/7206	0.00040578898842
ko04070	Phosphatidylinositol signaling system	33/1176	112/7206	0.000423552888668
ko04014	Ras signaling pathway	68/1176	279/7206	0.000479340966308
ko04072	Phospholipase D signaling pathway	51/1176	197/7206	0.00055845492938
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1176	14/7206	0.000584745309007
ko05205	Proteoglycans in cancer	25/1176	271/7206	0.000768398805616
ko05161	Hepatitis B	13/1176	173/7206	0.000796018116522
ko04371	Apelin signaling pathway	46/1176	177/7206	0.000896278184717
ko04915	Estrogen signaling pathway	36/1176	131/7206	0.00112680115202
ko05166	HTLV-I infection	28/1176	292/7206	0.00115254722531
ko04146	Peroxisome	4/1176	89/7206	0.00123180499749
ko00520	Amino sugar and nucleotide sugar metabolism	1/1176	55/7206	0.00135826834622
ko00480	Glutathione metabolism	1/1176	55/7206	0.00135826834622
ko04640	Hematopoietic cell lineage	2/1176	64/7206	0.0018194118659
ko00310	Lysine degradation	3/1176	73/7206	0.00217153075132
ko00330	Arginine and proline metabolism	2/1176	61/7206	0.00265320883818
ko04912	GnRH signaling pathway	33/1176	122/7206	0.00270894238288
ko04217	Necroptosis	15/1176	178/7206	0.00274619812239
ko04214	Apoptosis - fly	3/1176	72/7206	0.00328781861998
ko03420	Nucleotide excision repair	1/1176	46/7206	0.00442007780271
ko04657	IL-17 signaling pathway	5/1176	87/7206	0.00502891208351
ko04916	Melanogenesis	36/1176	142/7206	0.00555075691473
ko05321	Inflammatory bowel disease (IBD)	2/1176	56/7206	0.0057145419355
ko04668	TNF signaling pathway	9/1176	120/7206	0.00590875474185
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1176	100/7206	0.00601588480998
ko03022	Basal transcription factors	1/1176	44/7206	0.00668713264866
ko03018	RNA degradation	5/1176	84/7206	0.00696323492179
ko05144	Malaria	1/1176	45/7206	0.00697335127449
ko00071	Fatty acid degradation	1/1176	45/7206	0.00697335127449
ko01524	Platinum drug resistance	4/1176	76/7206	0.00709525118825
ko05145	Toxoplasmosis	10/1176	126/7206	0.00733483686856
ko04270	Vascular smooth muscle contraction	38/1176	154/7206	0.00772009609586
ko00240	Pyrimidine metabolism	8/1176	110/7206	0.00866170325663
ko05418	Fluid shear stress and atherosclerosis	16/1176	173/7206	0.00899898397311
ko04330	Notch signaling pathway	3/1176	62/7206	0.00924231833383
ko04622	RIG-I-like receptor signaling pathway	3/1176	62/7206	0.00924231833383
ko04978	Mineral absorption	13/1176	40/7206	0.00949129366115
ko04210	Apoptosis	17/1176	180/7206	0.0103193960565
ko04922	Glucagon signaling pathway	32/1176	128/7206	0.0107972146667
ko04630	Jak-STAT signaling pathway	11/1176	132/7206	0.011910375349
ko04658	Th1 and Th2 cell differentiation	7/1176	96/7206	0.01215275249
ko00590	Arachidonic acid metabolism	2/1176	52/7206	0.0126015144388
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1176	182/7206	0.0147265985837
ko03410	Base excision repair	1/1176	38/7206	0.0148906302593
ko04350	TGF-beta signaling pathway	8/1176	103/7206	0.0151998268016
ko00260	Glycine, serine and threonine metabolism	2/1176	48/7206	0.0176041792085
ko00562	Inositol phosphate metabolism	23/1176	89/7206	0.0201036770821
ko04620	Toll-like receptor signaling pathway	8/1176	100/7206	0.0202309273006
ko05131	Shigellosis	6/1176	82/7206	0.0236398640827
ko05034	Alcoholism	52/1176	238/7206	0.0252675996207
ko04062	Chemokine signaling pathway	45/1176	201/7206	0.0253909935921
ko04115	p53 signaling pathway	5/1176	74/7206	0.0254404672107
ko04974	Protein digestion and absorption	24/1176	96/7206	0.0256883929202
ko00600	Sphingolipid metabolism	4/1176	63/7206	0.0262149856376
ko00280	Valine, leucine and isoleucine degradation	3/1176	54/7206	0.026481715932
ko04923	Regulation of lipolysis in adipocytes	20/1176	77/7206	0.0287848033782
ko05222	Small cell lung cancer	7/1176	89/7206	0.0294633548654
ko04015	Rap1 signaling pathway	59/1176	278/7206	0.030954945201
ko00860	Porphyrin and chlorophyll metabolism	1/1176	34/7206	0.0335040585794
ko00500	Starch and sucrose metabolism	1/1176	35/7206	0.0349326506637
ko04114	Oocyte meiosis	32/1176	139/7206	0.0365354051794
ko05215	Prostate cancer	10/1176	111/7206	0.0374515307042
ko04930	Type II diabetes mellitus	15/1176	54/7206	0.0391952906645
ko04722	Neurotrophin signaling pathway	36/1176	160/7206	0.0392296726995
ko05133	Pertussis	7/1176	87/7206	0.0395479651213
ko04140	Autophagy - animal	17/1176	164/7206	0.0414517283758
ko05010	Alzheimer's disease	44/1176	202/7206	0.0418875578981
ko05231	Choline metabolism in cancer	31/1176	134/7206	0.0437514240589
ko05214	Glioma	20/1176	79/7206	0.0446045800811
ko05217	Basal cell carcinoma	5/1176	68/7206	0.0466457520491