ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	206/1265	423/7206	1.53151620832e-52
ko04724	Glutamatergic synapse	92/1265	152/7206	5.13255394639e-33
ko05033	Nicotine addiction	48/1265	56/7206	8.43925642343e-29
ko05032	Morphine addiction	69/1265	110/7206	2.55029223865e-26
ko04713	Circadian entrainment	77/1265	136/7206	4.06544583239e-25
ko04727	GABAergic synapse	67/1265	110/7206	1.62580733333e-24
ko04721	Synaptic vesicle cycle	55/1265	80/7206	3.97685458361e-24
ko04728	Dopaminergic synapse	87/1265	185/7206	6.9802195602e-21
ko04725	Cholinergic synapse	78/1265	160/7206	5.10942880684e-20
ko04020	Calcium signaling pathway	107/1265	265/7206	4.32047073022e-19
ko04024	cAMP signaling pathway	110/1265	279/7206	1.09514772741e-18
ko04723	Retrograde endocannabinoid signaling	78/1265	175/7206	3.96604248577e-17
ko04742	Taste transduction	39/1265	61/7206	8.33588438968e-16
ko04921	Oxytocin signaling pathway	85/1265	209/7206	1.3594615992e-15
ko04744	Phototransduction	28/1265	36/7206	3.83732056913e-15
ko04911	Insulin secretion	57/1265	117/7206	6.29721196012e-15
ko04726	Serotonergic synapse	61/1265	137/7206	1.25207806377e-13
ko04720	Long-term potentiation	48/1265	99/7206	1.12931527824e-12
ko04970	Salivary secretion	46/1265	95/7206	3.56730071484e-12
ko04261	Adrenergic signaling in cardiomyocytes	76/1265	205/7206	1.74518724013e-11
ko03040	Spliceosome	1/1265	145/7206	2.60412119866e-11
ko05031	Amphetamine addiction	43/1265	91/7206	5.03876125999e-11
ko04740	Olfactory transduction	39/1265	80/7206	1.234549017e-10
ko05203	Viral carcinogenesis	15/1265	277/7206	1.43802907212e-09
ko05168	Herpes simplex infection	6/1265	182/7206	4.28242466804e-09
ko04966	Collecting duct acid secretion	18/1265	26/7206	8.44449935995e-09
ko04925	Aldosterone synthesis and secretion	43/1265	105/7206	1.37089342121e-08
ko04022	cGMP-PKG signaling pathway	71/1265	216/7206	2.95872582743e-08
ko04360	Axon guidance	75/1265	233/7206	3.4377900317e-08
ko04971	Gastric acid secretion	40/1265	98/7206	4.98929191134e-08
ko03013	RNA transport	7/1265	166/7206	2.50684968692e-07
ko04924	Renin secretion	35/1265	86/7206	3.92770190803e-07
ko04540	Gap junction	46/1265	128/7206	4.71096211194e-07
ko04060	Cytokine-cytokine receptor interaction	10/1265	191/7206	5.66366928334e-07
ko04120	Ubiquitin mediated proteolysis	5/1265	138/7206	7.25553686564e-07
ko05322	Systemic lupus erythematosus	7/1265	151/7206	2.31933179671e-06
ko05030	Cocaine addiction	30/1265	73/7206	2.52156547098e-06
ko05164	Influenza A	9/1265	167/7206	4.21304063399e-06
ko04972	Pancreatic secretion	39/1265	111/7206	6.94046775479e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1265	74/7206	8.8920804593e-06
ko04010	MAPK signaling pathway	87/1265	321/7206	1.20752133151e-05
ko04621	NOD-like receptor signaling pathway	9/1265	157/7206	1.68375987096e-05
ko04745	Phototransduction - fly	18/1265	38/7206	2.13757237068e-05
ko05169	Epstein-Barr virus infection	15/1265	206/7206	2.40328388382e-05
ko05110	Vibrio cholerae infection	25/1265	63/7206	3.18193802379e-05
ko04730	Long-term depression	29/1265	78/7206	3.19063234409e-05
ko04514	Cell adhesion molecules (CAMs)	42/1265	130/7206	3.56499722542e-05
ko04260	Cardiac muscle contraction	34/1265	98/7206	4.05645890914e-05
ko04626	Plant-pathogen interaction	11/1265	18/7206	4.45133215574e-05
ko04141	Protein processing in endoplasmic reticulum	13/1265	184/7206	4.75008675133e-05
ko04610	Complement and coagulation cascades	2/1265	79/7206	7.09477856376e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1265	79/7206	7.09477856376e-05
ko04014	Ras signaling pathway	75/1265	279/7206	7.53737305247e-05
ko04070	Phosphatidylinositol signaling system	37/1265	112/7206	7.5373782816e-05
ko04976	Bile secretion	29/1265	80/7206	7.65457558254e-05
ko04371	Apelin signaling pathway	52/1265	177/7206	8.28037804364e-05
ko04110	Cell cycle	9/1265	145/7206	9.2091302345e-05
ko05140	Leishmaniasis	2/1265	75/7206	0.000103495441795
ko04064	NF-kappa B signaling pathway	4/1265	96/7206	0.000119841638092
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1265	79/7206	0.000135002198298
ko05162	Measles	7/1265	120/7206	0.000235598110583
ko05414	Dilated cardiomyopathy	35/1265	112/7206	0.000374722234396
ko05205	Proteoglycans in cancer	27/1265	271/7206	0.000448072871302
ko05161	Hepatitis B	14/1265	173/7206	0.000520679579945
ko00480	Glutathione metabolism	1/1265	55/7206	0.000523171470205
ko04072	Phospholipase D signaling pathway	54/1265	197/7206	0.00056737492562
ko04964	Proximal tubule bicarbonate reclamation	13/1265	29/7206	0.000590780131601
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1265	59/7206	0.000822008793183
ko00240	Pyrimidine metabolism	7/1265	110/7206	0.000904382470609
ko04214	Apoptosis - fly	3/1265	72/7206	0.00095737993197
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1265	14/7206	0.00097258630715
ko04750	Inflammatory mediator regulation of TRP channels	36/1265	122/7206	0.00105395301133
ko04915	Estrogen signaling pathway	38/1265	131/7206	0.00106127694713
ko04923	Regulation of lipolysis in adipocytes	25/1265	77/7206	0.00132584986944
ko04146	Peroxisome	5/1265	89/7206	0.00173692360849
ko04612	Antigen processing and presentation	4/1265	77/7206	0.00226136836047
ko05321	Inflammatory bowel disease (IBD)	2/1265	56/7206	0.00247848063563
ko00071	Fatty acid degradation	1/1265	45/7206	0.00274690864298
ko03420	Nucleotide excision repair	1/1265	46/7206	0.00279876184689
ko05166	HTLV-I infection	33/1265	292/7206	0.00354870364673
ko03022	Basal transcription factors	1/1265	44/7206	0.00430220043996
ko00310	Lysine degradation	4/1265	73/7206	0.00470572417724
ko04668	TNF signaling pathway	10/1265	120/7206	0.00520068554017
ko00590	Arachidonic acid metabolism	2/1265	52/7206	0.00537316852507
ko04350	TGF-beta signaling pathway	8/1265	103/7206	0.00593532783912
ko04622	RIG-I-like receptor signaling pathway	3/1265	62/7206	0.00634146319541
ko05145	Toxoplasmosis	11/1265	126/7206	0.00638525609711
ko04657	IL-17 signaling pathway	6/1265	87/7206	0.00651303251333
ko00562	Inositol phosphate metabolism	26/1265	89/7206	0.00702113359216
ko04912	GnRH signaling pathway	33/1265	122/7206	0.00796492664964
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1265	100/7206	0.0080000092788
ko03018	RNA degradation	6/1265	84/7206	0.00891046450141
ko01524	Platinum drug resistance	5/1265	76/7206	0.00921420091548
ko00630	Glyoxylate and dicarboxylate metabolism	1/1265	38/7206	0.00943052672225
ko03410	Base excision repair	1/1265	38/7206	0.00943052672225
ko04922	Glucagon signaling pathway	34/1265	128/7206	0.00961668801434
ko05131	Shigellosis	6/1265	82/7206	0.0122935510874
ko04115	p53 signaling pathway	5/1265	74/7206	0.0129288714027
ko04270	Vascular smooth muscle contraction	39/1265	154/7206	0.013528995803
ko04658	Th1 and Th2 cell differentiation	8/1265	96/7206	0.0145265694597
ko05133	Pertussis	7/1265	87/7206	0.0156375721139
ko05144	Malaria	2/1265	45/7206	0.0168966574814
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1265	182/7206	0.0175194344117
ko04330	Notch signaling pathway	4/1265	62/7206	0.0180296880826
ko04916	Melanogenesis	36/1265	142/7206	0.0187214868158
ko05120	Epithelial cell signaling in Helicobacter pylori infection	25/1265	92/7206	0.0187720679598
ko04015	Rap1 signaling pathway	64/1265	278/7206	0.019384780021
ko00500	Starch and sucrose metabolism	1/1265	35/7206	0.0226097071246
ko04620	Toll-like receptor signaling pathway	9/1265	100/7206	0.0235667773547
ko00330	Arginine and proline metabolism	4/1265	61/7206	0.0260742164012
ko05206	MicroRNAs in cancer	20/1265	177/7206	0.0272875084507
ko04217	Necroptosis	20/1265	178/7206	0.0275556931986
ko05132	Salmonella infection	9/1265	98/7206	0.0312553436745
ko05418	Fluid shear stress and atherosclerosis	20/1265	173/7206	0.0337671653566
ko05222	Small cell lung cancer	8/1265	89/7206	0.0343704727441
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1265	15/7206	0.0344678029861
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1265	40/7206	0.0354963462799
ko00260	Glycine, serine and threonine metabolism	3/1265	48/7206	0.0359236841843
ko00380	Tryptophan metabolism	3/1265	50/7206	0.0374617968294
ko05231	Choline metabolism in cancer	33/1265	134/7206	0.0382521828193
ko00600	Sphingolipid metabolism	5/1265	63/7206	0.0450165693476
ko04722	Neurotrophin signaling pathway	38/1265	160/7206	0.0451929073238
ko04640	Hematopoietic cell lineage	5/1265	64/7206	0.0457018716238
ko05320	Autoimmune thyroid disease	1/1265	29/7206	0.0478652334362
ko04062	Chemokine signaling pathway	46/1265	201/7206	0.0482031918099
ko00280	Valine, leucine and isoleucine degradation	4/1265	54/7206	0.0482065169595