ko pathway ratio_in_study ratio_in_pop p_value ko04744 Phototransduction 24/517 36/7206 1.15480068685e-19 ko05032 Morphine addiction 29/517 110/7206 3.8913126056e-10 ko04724 Glutamatergic synapse 32/517 152/7206 2.0702306768e-08 ko04725 Cholinergic synapse 33/517 160/7206 2.11294332668e-08 ko04024 cAMP signaling pathway 46/517 279/7206 7.36727860496e-08 ko04726 Serotonergic synapse 28/517 137/7206 3.10053228886e-07 ko04080 Neuroactive ligand-receptor interaction 59/517 423/7206 4.73534693711e-07 ko04727 GABAergic synapse 24/517 110/7206 6.28286991262e-07 ko05033 Nicotine addiction 16/517 56/7206 1.10333435393e-06 ko04020 Calcium signaling pathway 41/517 265/7206 2.25196423624e-06 ko04713 Circadian entrainment 26/517 136/7206 3.10825929504e-06 ko04728 Dopaminergic synapse 31/517 185/7206 7.37505235498e-06 ko04070 Phosphatidylinositol signaling system 22/517 112/7206 1.13771049865e-05 ko04723 Retrograde endocannabinoid signaling 29/517 175/7206 1.799312328e-05 ko04710 Circadian rhythm 12/517 43/7206 3.20672808371e-05 ko04921 Oxytocin signaling pathway 32/517 209/7206 3.35133519558e-05 ko04014 Ras signaling pathway 38/517 279/7206 0.000118314393389 ko04072 Phospholipase D signaling pathway 29/517 197/7206 0.000197154205594 ko04010 MAPK signaling pathway 41/517 321/7206 0.000231247780751 ko05322 Systemic lupus erythematosus 1/517 151/7206 0.000318983491615 ko04925 Aldosterone synthesis and secretion 18/517 105/7206 0.000426243703441 ko03040 Spliceosome 1/517 145/7206 0.000464960808226 ko03013 RNA transport 2/517 166/7206 0.000665280289505 ko04911 Insulin secretion 19/517 117/7206 0.000755111003248 ko04145 Phagosome 2/517 162/7206 0.000976344135407 ko04711 Circadian rhythm - fly 5/517 13/7206 0.00147860499509 ko05230 Central carbon metabolism in cancer 14/517 81/7206 0.00167033662225 ko04750 Inflammatory mediator regulation of TRP channels 18/517 122/7206 0.00366107737601 ko04360 Axon guidance 29/517 233/7206 0.00405249866478 ko00562 Inositol phosphate metabolism 14/517 89/7206 0.00539302055314 ko05031 Amphetamine addiction 14/517 91/7206 0.00614990204418 ko05223 Non-small cell lung cancer 11/517 66/7206 0.00675810081228 ko04261 Adrenergic signaling in cardiomyocytes 25/517 205/7206 0.00841161209245 ko04022 cGMP-PKG signaling pathway 26/517 216/7206 0.0100949654656 ko04721 Synaptic vesicle cycle 12/517 80/7206 0.013607156252 ko04930 Type II diabetes mellitus 9/517 54/7206 0.013700805983 ko04720 Long-term potentiation 14/517 99/7206 0.0158712888759 ko05203 Viral carcinogenesis 10/517 277/7206 0.0169324550786 ko05231 Choline metabolism in cancer 17/517 134/7206 0.0177217498508 ko05030 Cocaine addiction 11/517 73/7206 0.0184882320139 ko04071 Sphingolipid signaling pathway 20/517 162/7206 0.0192229857378 ko02010 ABC transporters 7/517 39/7206 0.0193593206784 ko05323 Rheumatoid arthritis 1/517 89/7206 0.0205760773998 ko04960 Aldosterone-regulated sodium reabsorption 7/517 41/7206 0.025020528772 ko04062 Chemokine signaling pathway 23/517 201/7206 0.0252775482807 ko04722 Neurotrophin signaling pathway 19/517 160/7206 0.0284771220882 ko00230 Purine metabolism 22/517 194/7206 0.0327632757721 ko04919 Thyroid hormone signaling pathway 17/517 143/7206 0.0332103424424 ko04110 Cell cycle 4/517 145/7206 0.0336602532566 ko04972 Pancreatic secretion 14/517 111/7206 0.0382780255322 ko04742 Taste transduction 9/517 61/7206 0.0391671490279 ko04141 Protein processing in endoplasmic reticulum 6/517 184/7206 0.0409257592433 ko04015 Rap1 signaling pathway 29/517 278/7206 0.0426568166795 ko05130 Pathogenic Escherichia coli infection 1/517 77/7206 0.0427140713157 ko04612 Antigen processing and presentation 1/517 77/7206 0.0427140713157 ko04610 Complement and coagulation cascades 1/517 79/7206 0.043986568875 ko04931 Insulin resistance 16/517 137/7206 0.0448649141624 ko04120 Ubiquitin mediated proteolysis 4/517 138/7206 0.0454379938991