ko pathway ratio_in_study ratio_in_pop p_value ko03008 Ribosome biogenesis in eukaryotes 46/438 79/7206 3.42210969199e-36 ko03040 Spliceosome 59/438 145/7206 8.65662470182e-35 ko03013 RNA transport 57/438 166/7206 5.49616252152e-29 ko03030 DNA replication 21/438 38/7206 1.98972881952e-16 ko03020 RNA polymerase 18/438 29/7206 1.70036010063e-15 ko00240 Pyrimidine metabolism 30/438 110/7206 1.11985105829e-12 ko03050 Proteasome 16/438 54/7206 6.53550305611e-08 ko04110 Cell cycle 27/438 145/7206 1.2819271391e-07 ko00230 Purine metabolism 32/438 194/7206 1.68525425394e-07 ko03430 Mismatch repair 10/438 22/7206 2.07555411747e-07 ko04144 Endocytosis 3/438 342/7206 1.19781184829e-06 ko03018 RNA degradation 18/438 84/7206 2.05273027667e-06 ko03420 Nucleotide excision repair 13/438 46/7206 2.07597185945e-06 ko04810 Regulation of actin cytoskeleton 1/438 264/7206 2.12894984502e-06 ko03015 mRNA surveillance pathway 19/438 93/7206 2.29186290266e-06 ko03010 Ribosome 23/438 129/7206 2.44435579965e-06 ko04024 cAMP signaling pathway 2/438 279/7206 8.21688815867e-06 ko04360 Axon guidance 1/438 233/7206 9.6492255483e-06 ko04022 cGMP-PKG signaling pathway 1/438 216/7206 3.2020737538e-05 ko03060 Protein export 8/438 23/7206 3.80700041353e-05 ko04015 Rap1 signaling pathway 3/438 278/7206 5.11573134707e-05 ko05169 Epstein-Barr virus infection 28/438 206/7206 7.47277982635e-05 ko04623 Cytosolic DNA-sensing pathway 10/438 41/7206 0.000126285850447 ko00970 Aminoacyl-tRNA biosynthesis 10/438 44/7206 0.000237114248979 ko04014 Ras signaling pathway 4/438 279/7206 0.000270011953424 ko04510 Focal adhesion 3/438 240/7206 0.000302248126077 ko05200 Pathways in cancer 13/438 492/7206 0.000395805677485 ko04010 MAPK signaling pathway 6/438 321/7206 0.000445185554594 ko04062 Chemokine signaling pathway 2/438 201/7206 0.000480803965704 ko04261 Adrenergic signaling in cardiomyocytes 2/438 205/7206 0.000495534865551 ko03440 Homologous recombination 9/438 41/7206 0.000637655474228 ko03460 Fanconi anemia pathway 10/438 51/7206 0.000832776289881 ko04113 Meiosis - yeast 12/438 70/7206 0.000923814185836 ko04111 Cell cycle - yeast 14/438 90/7206 0.000973860158892 ko05012 Parkinson's disease 1/438 155/7206 0.00102550415639 ko04270 Vascular smooth muscle contraction 1/438 154/7206 0.00102619079829 ko04725 Cholinergic synapse 1/438 160/7206 0.0010971032458 ko04724 Glutamatergic synapse 1/438 152/7206 0.0015555774916 ko04723 Retrograde endocannabinoid signaling 2/438 175/7206 0.00205914770381 ko04068 FoxO signaling pathway 2/438 167/7206 0.00294977281779 ko04713 Circadian entrainment 1/438 136/7206 0.00321278946459 ko04726 Serotonergic synapse 1/438 137/7206 0.00323521781162 ko04072 Phospholipase D signaling pathway 3/438 197/7206 0.00353596090452 ko04550 Signaling pathways regulating pluripotency of stem cells 2/438 165/7206 0.0043224933583 ko04922 Glucagon signaling pathway 1/438 128/7206 0.00467381355867 ko05142 Chagas disease (American trypanosomiasis) 1/438 130/7206 0.00470018632751 ko04514 Cell adhesion molecules (CAMs) 1/438 130/7206 0.00470018632751 ko04630 Jak-STAT signaling pathway 1/438 132/7206 0.00480926931781 ko04390 Hippo signaling pathway 3/438 188/7206 0.00488015061162 ko04380 Osteoclast differentiation 1/438 134/7206 0.00500334053364 ko04912 GnRH signaling pathway 1/438 122/7206 0.00680276691558 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/438 182/7206 0.00685924367589 ko04660 T cell receptor signaling pathway 1/438 124/7206 0.00687512127098 ko04728 Dopaminergic synapse 3/438 185/7206 0.0070817456146 ko03410 Base excision repair 7/438 38/7206 0.00712674064742 ko04921 Oxytocin signaling pathway 4/438 209/7206 0.00738680951301 ko04151 PI3K-Akt signaling pathway 12/438 390/7206 0.00854704279263 ko04142 Lysosome 2/438 151/7206 0.00868352519298 ko04670 Leukocyte transendothelial migration 2/438 151/7206 0.00868352519298 ko04371 Apelin signaling pathway 3/438 177/7206 0.00972425349639 ko04013 MAPK signaling pathway - fly 1/438 115/7206 0.00988564538217 ko04530 Tight junction 5/438 228/7206 0.0102959657529 ko04727 GABAergic synapse 1/438 110/7206 0.0144060001342 ko05032 Morphine addiction 1/438 110/7206 0.0144060001342 ko04972 Pancreatic secretion 1/438 111/7206 0.0145208331697 ko04931 Insulin resistance 2/438 137/7206 0.0173036805369 ko04611 Platelet activation 3/438 163/7206 0.0186766845646 ko04520 Adherens junction 1/438 103/7206 0.0208208156284 ko04925 Aldosterone synthesis and secretion 1/438 105/7206 0.0211658061456 ko04540 Gap junction 2/438 128/7206 0.0240947525782 ko04915 Estrogen signaling pathway 2/438 131/7206 0.0245661496053 ko04621 NOD-like receptor signaling pathway 3/438 157/7206 0.0260223377695 ko05205 Proteoglycans in cancer 8/438 271/7206 0.0266430826286 ko00670 One carbon pool by folate 4/438 20/7206 0.0299944302795 ko05211 Renal cell carcinoma 1/438 96/7206 0.0300503844053 ko04658 Th1 and Th2 cell differentiation 1/438 96/7206 0.0300503844053 ko04064 NF-kappa B signaling pathway 1/438 96/7206 0.0300503844053 ko05132 Salmonella infection 1/438 98/7206 0.0304570199919 ko04620 Toll-like receptor signaling pathway 1/438 100/7206 0.0313034421785 ko04668 TNF signaling pathway 2/438 120/7206 0.033839110677 ko04750 Inflammatory mediator regulation of TRP channels 2/438 122/7206 0.0339406984884 ko04666 Fc gamma R-mediated phagocytosis 2/438 122/7206 0.0339406984884 ko05145 Toxoplasmosis 2/438 126/7206 0.0352845714152 ko04146 Peroxisome 1/438 89/7206 0.0432983136512 ko05323 Rheumatoid arthritis 1/438 89/7206 0.0432983136512 ko04391 Hippo signaling pathway - fly 1/438 90/7206 0.0434582653256 ko05031 Amphetamine addiction 1/438 91/7206 0.043768453702 ko05152 Tuberculosis 5/438 187/7206 0.0438260660076 ko05120 Epithelial cell signaling in Helicobacter pylori infection 1/438 92/7206 0.0442282589011 ko04140 Autophagy - animal 4/438 164/7206 0.0463598475441