ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 116/764 423/7206 9.24289993683e-24 ko04724 Glutamatergic synapse 56/764 152/7206 3.97246760812e-18 ko05033 Nicotine addiction 29/764 56/7206 1.4902033152e-14 ko04727 GABAergic synapse 41/764 110/7206 8.80270828883e-14 ko05032 Morphine addiction 39/764 110/7206 2.29010534675e-12 ko04725 Cholinergic synapse 48/764 160/7206 7.5175536141e-12 ko04713 Circadian entrainment 43/764 136/7206 1.39997825747e-11 ko04728 Dopaminergic synapse 52/764 185/7206 1.56156267349e-11 ko04020 Calcium signaling pathway 61/764 265/7206 2.56988615257e-09 ko04726 Serotonergic synapse 39/764 137/7206 3.90485489911e-09 ko04721 Synaptic vesicle cycle 28/764 80/7206 4.23709670235e-09 ko04911 Insulin secretion 35/764 117/7206 5.99104951784e-09 ko04723 Retrograde endocannabinoid signaling 45/764 175/7206 1.07790707964e-08 ko05031 Amphetamine addiction 28/764 91/7206 1.0365659803e-07 ko04970 Salivary secretion 28/764 95/7206 2.84015146864e-07 ko04720 Long-term potentiation 28/764 99/7206 7.25994608351e-07 ko04921 Oxytocin signaling pathway 46/764 209/7206 1.00277887259e-06 ko05322 Systemic lupus erythematosus 1/764 151/7206 1.38825320716e-06 ko04024 cAMP signaling pathway 56/764 279/7206 2.12407597203e-06 ko04925 Aldosterone synthesis and secretion 28/764 105/7206 2.64183447962e-06 ko03040 Spliceosome 1/764 145/7206 3.33001072749e-06 ko04022 cGMP-PKG signaling pathway 45/764 216/7206 8.04032917663e-06 ko04360 Axon guidance 47/764 233/7206 1.10033773328e-05 ko04730 Long-term depression 22/764 78/7206 1.1750931951e-05 ko04070 Phosphatidylinositol signaling system 28/764 112/7206 1.34046089471e-05 ko04971 Gastric acid secretion 25/764 98/7206 2.08530986655e-05 ko04960 Aldosterone-regulated sodium reabsorption 14/764 41/7206 4.59237323662e-05 ko04514 Cell adhesion molecules (CAMs) 29/764 130/7206 7.77679983364e-05 ko03013 RNA transport 4/764 166/7206 0.000100509832777 ko05168 Herpes simplex infection 5/764 182/7206 0.000121009725237 ko04010 MAPK signaling pathway 56/764 321/7206 0.000130475142658 ko04014 Ras signaling pathway 50/764 279/7206 0.000149434172648 ko05030 Cocaine addiction 19/764 73/7206 0.000151031830333 ko04750 Inflammatory mediator regulation of TRP channels 27/764 122/7206 0.000160021657419 ko05014 Amyotrophic lateral sclerosis (ALS) 19/764 74/7206 0.000183449475591 ko04120 Ubiquitin mediated proteolysis 3/764 138/7206 0.000238695155582 ko04972 Pancreatic secretion 25/764 111/7206 0.000239231480388 ko04261 Adrenergic signaling in cardiomyocytes 39/764 205/7206 0.000296217104 ko04961 Endocrine and other factor-regulated calcium reabsorption 16/764 59/7206 0.000298018540938 ko04930 Type II diabetes mellitus 15/764 54/7206 0.000344252584735 ko04745 Phototransduction - fly 12/764 38/7206 0.000368702374035 ko04742 Taste transduction 16/764 61/7206 0.000449805974883 ko04072 Phospholipase D signaling pathway 37/764 197/7206 0.000562471948951 ko04710 Circadian rhythm 12/764 43/7206 0.00126981142025 ko04922 Glucagon signaling pathway 25/764 128/7206 0.00212470287681 ko04540 Gap junction 25/764 128/7206 0.00212470287681 ko04141 Protein processing in endoplasmic reticulum 8/764 184/7206 0.0033237738073 ko04924 Renin secretion 18/764 86/7206 0.00411354625917 ko04662 B cell receptor signaling pathway 18/764 88/7206 0.00499224058871 ko04919 Thyroid hormone signaling pathway 26/764 143/7206 0.00556411795978 ko04711 Circadian rhythm - fly 5/764 13/7206 0.00822769443502 ko04964 Proximal tubule bicarbonate reclamation 8/764 29/7206 0.00871043267318 ko04110 Cell cycle 6/764 145/7206 0.00885112880947 ko04015 Rap1 signaling pathway 43/764 278/7206 0.00964208533111 ko04973 Carbohydrate digestion and absorption 10/764 42/7206 0.0106669268446 ko04918 Thyroid hormone synthesis 17/764 86/7206 0.0118947645959 ko04012 ErbB signaling pathway 20/764 109/7206 0.0119323274206 ko00562 Inositol phosphate metabolism 17/764 89/7206 0.0142022863287 ko05130 Pathogenic Escherichia coli infection 2/764 77/7206 0.0149495292313 ko04612 Antigen processing and presentation 2/764 77/7206 0.0149495292313 ko05162 Measles 5/764 120/7206 0.0162625205778 ko04371 Apelin signaling pathway 29/764 177/7206 0.0179236578215 ko04650 Natural killer cell mediated cytotoxicity 18/764 97/7206 0.0183202789457 ko00330 Arginine and proline metabolism 1/764 61/7206 0.0189037795383 ko04062 Chemokine signaling pathway 32/764 201/7206 0.0193204214975 ko05110 Vibrio cholerae infection 13/764 63/7206 0.0205211099722 ko05140 Leishmaniasis 2/764 75/7206 0.0216772877989 ko05231 Choline metabolism in cancer 23/764 134/7206 0.0220224203599 ko05133 Pertussis 3/764 87/7206 0.0225727273851 ko04146 Peroxisome 3/764 89/7206 0.0227783255182 ko04666 Fc gamma R-mediated phagocytosis 21/764 122/7206 0.0247120390882 ko05214 Glioma 15/764 79/7206 0.0249573459899 ko04270 Vascular smooth muscle contraction 25/764 154/7206 0.0328298105188 ko04626 Plant-pathogen interaction 5/764 18/7206 0.0350735446517 ko04916 Melanogenesis 23/764 142/7206 0.0376423059307 ko04370 VEGF signaling pathway 14/764 77/7206 0.0389678539963 ko05167 Kaposi's sarcoma-associated herpesvirus infection 29/764 191/7206 0.0425402590931 ko04260 Cardiac muscle contraction 17/764 98/7206 0.0447878800532 ko05169 Epstein-Barr virus infection 13/764 206/7206 0.0497456639151