ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 43/327 145/7206 2.66077603501e-24 ko04110 Cell cycle 37/327 145/7206 1.49133728899e-18 ko03030 DNA replication 18/327 38/7206 6.17357665611e-15 ko04111 Cell cycle - yeast 26/327 90/7206 9.31918014456e-15 ko03460 Fanconi anemia pathway 18/327 51/7206 2.98752750455e-12 ko03410 Base excision repair 15/327 38/7206 3.108126992e-11 ko04113 Meiosis - yeast 18/327 70/7206 1.12716036371e-09 ko03440 Homologous recombination 14/327 41/7206 1.38073694011e-09 ko00240 Pyrimidine metabolism 21/327 110/7206 1.54852193171e-08 ko03013 RNA transport 25/327 166/7206 9.49451654584e-08 ko04151 PI3K-Akt signaling pathway 1/327 390/7206 2.720577718e-07 ko03430 Mismatch repair 8/327 22/7206 3.02112342369e-06 ko03420 Nucleotide excision repair 11/327 46/7206 4.54410221314e-06 ko04144 Endocytosis 2/327 342/7206 2.51353752152e-05 ko05322 Systemic lupus erythematosus 19/327 151/7206 4.76490275164e-05 ko04015 Rap1 signaling pathway 1/327 278/7206 4.90023792332e-05 ko04024 cAMP signaling pathway 1/327 279/7206 4.9240055797e-05 ko04020 Calcium signaling pathway 1/327 265/7206 0.000111669875834 ko05166 HTLV-I infection 28/327 292/7206 0.000145182131937 ko04014 Ras signaling pathway 2/327 279/7206 0.000346648052446 ko04510 Focal adhesion 1/327 240/7206 0.000363297673978 ko04530 Tight junction 1/327 228/7206 0.000509557531779 ko04114 Oocyte meiosis 16/327 139/7206 0.000524420158803 ko03022 Basal transcription factors 8/327 44/7206 0.00069834631422 ko04810 Regulation of actin cytoskeleton 2/327 264/7206 0.000732329900821 ko04022 cGMP-PKG signaling pathway 1/327 216/7206 0.000734921409422 ko03015 mRNA surveillance pathway 12/327 93/7206 0.000945541531483 ko04921 Oxytocin signaling pathway 1/327 209/7206 0.00108216869605 ko04120 Ubiquitin mediated proteolysis 15/327 138/7206 0.00140898017586 ko04010 MAPK signaling pathway 4/327 321/7206 0.00143938302749 ko04062 Chemokine signaling pathway 1/327 201/7206 0.00159002377505 ko04261 Adrenergic signaling in cardiomyocytes 1/327 205/7206 0.00166949979616 ko05203 Viral carcinogenesis 24/327 277/7206 0.00272242142302 ko04728 Dopaminergic synapse 1/327 185/7206 0.00343028096496 ko05152 Tuberculosis 1/327 187/7206 0.0035205935337 ko04910 Insulin signaling pathway 1/327 172/7206 0.00487639788315 ko04371 Apelin signaling pathway 1/327 177/7206 0.00503529664278 ko04330 Notch signaling pathway 8/327 62/7206 0.00656485071157 ko04611 Platelet activation 1/327 163/7206 0.00708443065545 ko04145 Phagosome 1/327 162/7206 0.00709203317586 ko04140 Autophagy - animal 1/327 164/7206 0.00709322613482 ko05164 Influenza A 1/327 167/7206 0.00721885439408 ko04072 Phospholipase D signaling pathway 2/327 197/7206 0.0088234136042 ko03008 Ribosome biogenesis in eukaryotes 9/327 79/7206 0.00914810863984 ko04270 Vascular smooth muscle contraction 1/327 154/7206 0.0102741361643 ko04621 NOD-like receptor signaling pathway 1/327 157/7206 0.0103701787443 ko05205 Proteoglycans in cancer 4/327 271/7206 0.0104218630507 ko04722 Neurotrophin signaling pathway 1/327 160/7206 0.010676487425 ko04060 Cytokine-cytokine receptor interaction 2/327 191/7206 0.0125439825607 ko03018 RNA degradation 9/327 84/7206 0.0134407950819 ko04670 Leukocyte transendothelial migration 1/327 151/7206 0.0154079122921 ko04218 Cellular senescence 15/327 177/7206 0.0166777742121 ko00310 Lysine degradation 8/327 73/7206 0.0170036713131 ko04141 Protein processing in endoplasmic reticulum 2/327 184/7206 0.0179092769344 ko00230 Purine metabolism 16/327 194/7206 0.0207624605156 ko04550 Signaling pathways regulating pluripotency of stem cells 14/327 165/7206 0.0213800390724 ko04931 Insulin resistance 1/327 137/7206 0.0214901657362 ko04139 Mitophagy - yeast 5/327 37/7206 0.0246707783264 ko04914 Progesterone-mediated oocyte maturation 10/327 104/7206 0.026891187325 ko05168 Herpes simplex infection 15/327 182/7206 0.0274548218902 ko01200 Carbon metabolism 1/327 128/7206 0.0309711986362 ko04540 Gap junction 1/327 128/7206 0.0309711986362 ko05202 Transcriptional misregulation in cancer 15/327 188/7206 0.0309918793654 ko04514 Cell adhesion molecules (CAMs) 1/327 130/7206 0.0311671077888 ko04933 AGE-RAGE signaling pathway in diabetic complications 1/327 135/7206 0.0327372853555 ko04152 AMPK signaling pathway 2/327 161/7206 0.0347579297987 ko05034 Alcoholism 18/327 238/7206 0.0370340160229 ko05169 Epstein-Barr virus infection 16/327 206/7206 0.0385862489296 ko03020 RNA polymerase 4/327 29/7206 0.0403838902337 ko05162 Measles 1/327 120/7206 0.0446220368347 ko04211 Longevity regulating pathway 1/327 123/7206 0.0453934732884 ko04066 HIF-1 signaling pathway 1/327 123/7206 0.0453934732884 ko04660 T cell receptor signaling pathway 1/327 124/7206 0.0458178781512 ko04115 p53 signaling pathway 7/327 74/7206 0.0497480801543