ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 80/653 423/7206 7.00158508379e-11 ko04713 Circadian entrainment 36/653 136/7206 1.92956196119e-09 ko04020 Calcium signaling pathway 52/653 265/7206 7.51557918425e-08 ko04022 cGMP-PKG signaling pathway 42/653 216/7206 1.49835058953e-06 ko04724 Glutamatergic synapse 33/653 152/7206 1.89434336515e-06 ko04725 Cholinergic synapse 33/653 160/7206 4.94728593261e-06 ko05033 Nicotine addiction 17/653 56/7206 5.11185659569e-06 ko04911 Insulin secretion 26/653 117/7206 1.21000086829e-05 ko04710 Circadian rhythm 14/653 43/7206 1.42750223597e-05 ko03040 Spliceosome 1/653 145/7206 2.61998412675e-05 ko00120 Primary bile acid biosynthesis 9/653 20/7206 2.62337463864e-05 ko04970 Salivary secretion 22/653 95/7206 2.86086960761e-05 ko05031 Amphetamine addiction 21/653 91/7206 4.57815938454e-05 ko04971 Gastric acid secretion 22/653 98/7206 4.76697350347e-05 ko04024 cAMP signaling pathway 46/653 279/7206 6.56051070892e-05 ko04921 Oxytocin signaling pathway 37/653 209/7206 6.68505379277e-05 ko04728 Dopaminergic synapse 34/653 185/7206 6.88692524728e-05 ko05032 Morphine addiction 23/653 110/7206 0.000131012373634 ko03010 Ribosome 1/653 129/7206 0.000132426574074 ko03013 RNA transport 3/653 166/7206 0.000182566794454 ko04727 GABAergic synapse 22/653 110/7206 0.000314360546615 ko04972 Pancreatic secretion 22/653 111/7206 0.000353200169614 ko04070 Phosphatidylinositol signaling system 22/653 112/7206 0.000397370700668 ko05166 HTLV-I infection 11/653 292/7206 0.000544491874808 ko05203 Viral carcinogenesis 10/653 277/7206 0.000565863438491 ko04924 Renin secretion 18/653 86/7206 0.000838401255637 ko04270 Vascular smooth muscle contraction 27/653 154/7206 0.000874727739676 ko04110 Cell cycle 3/653 145/7206 0.00109936587845 ko04261 Adrenergic signaling in cardiomyocytes 33/653 205/7206 0.00114173514754 ko04925 Aldosterone synthesis and secretion 20/653 105/7206 0.00152771312049 ko04745 Phototransduction - fly 10/653 38/7206 0.00158259216801 ko04730 Long-term depression 16/653 78/7206 0.0020022614739 ko04120 Ubiquitin mediated proteolysis 3/653 138/7206 0.00230133587875 ko05322 Systemic lupus erythematosus 4/653 151/7206 0.00245850746791 ko04922 Glucagon signaling pathway 22/653 128/7206 0.00283607255053 ko04964 Proximal tubule bicarbonate reclamation 8/653 29/7206 0.00334811439484 ko00051 Fructose and mannose metabolism 10/653 42/7206 0.00353821006974 ko05168 Herpes simplex infection 6/653 182/7206 0.00366572481348 ko05164 Influenza A 5/653 167/7206 0.0037053100776 ko04720 Long-term potentiation 18/653 99/7206 0.00392188453703 ko04721 Synaptic vesicle cycle 15/653 80/7206 0.00538582567235 ko04976 Bile secretion 15/653 80/7206 0.00538582567235 ko04974 Protein digestion and absorption 17/653 96/7206 0.00633245670009 ko02010 ABC transporters 9/653 39/7206 0.0069173343934 ko04371 Apelin signaling pathway 27/653 177/7206 0.0073230943193 ko00710 Carbon fixation in photosynthetic organisms 7/653 27/7206 0.00862009692653 ko05130 Pathogenic Escherichia coli infection 1/653 77/7206 0.0089659359046 ko00680 Methane metabolism 8/653 34/7206 0.00945951510224 ko04960 Aldosterone-regulated sodium reabsorption 9/653 41/7206 0.00971798272183 ko01230 Biosynthesis of amino acids 15/653 85/7206 0.0115541122652 ko00362 Benzoate degradation 3/653 6/7206 0.012023043433 ko05169 Epstein-Barr virus infection 9/653 206/7206 0.0135041953958 ko04660 T cell receptor signaling pathway 4/653 124/7206 0.0172934496543 ko05200 Pathways in cancer 30/653 492/7206 0.0179538546828 ko04014 Ras signaling pathway 37/653 279/7206 0.0186096245796 ko04626 Plant-pathogen interaction 5/653 18/7206 0.0190216224902 ko04614 Renin-angiotensin system 5/653 18/7206 0.0190216224902 ko04141 Protein processing in endoplasmic reticulum 8/653 184/7206 0.0191417604607 ko04144 Endocytosis 19/653 342/7206 0.0200695914239 ko05030 Cocaine addiction 13/653 73/7206 0.0209213446116 ko00010 Glycolysis / Gluconeogenesis 13/653 74/7206 0.0218082968909 ko05014 Amyotrophic lateral sclerosis (ALS) 13/653 74/7206 0.0218082968909 ko05220 Chronic myeloid leukemia 2/653 85/7206 0.0223155922087 ko00592 alpha-Linolenic acid metabolism 5/653 19/7206 0.0239405717454 ko04711 Circadian rhythm - fly 4/653 13/7206 0.0246060026417 ko04978 Mineral absorption 8/653 40/7206 0.0247870936866 ko00561 Glycerolipid metabolism 11/653 63/7206 0.0270805188527 ko04550 Signaling pathways regulating pluripotency of stem cells 7/653 165/7206 0.0272474242863 ko03320 PPAR signaling pathway 12/653 69/7206 0.0309394259231 ko04740 Olfactory transduction 13/653 80/7206 0.0310392562 ko00562 Inositol phosphate metabolism 14/653 89/7206 0.0384352415844 ko04622 RIG-I-like receptor signaling pathway 1/653 62/7206 0.0415804408028 ko05221 Acute myeloid leukemia 1/653 63/7206 0.0426091672234 ko05161 Hepatitis B 8/653 173/7206 0.0429178281627 ko05224 Breast cancer 8/653 174/7206 0.0433303238939 ko04723 Retrograde endocannabinoid signaling 24/653 175/7206 0.0438651523224 ko03015 mRNA surveillance pathway 3/653 93/7206 0.0450153530512 ko04621 NOD-like receptor signaling pathway 7/653 157/7206 0.047361395227 ko04260 Cardiac muscle contraction 15/653 98/7206 0.0480314040473 ko00564 Glycerophospholipid metabolism 15/653 99/7206 0.0493168706787