ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	157/858	423/7206	3.51576693283e-44
ko04724	Glutamatergic synapse	69/858	152/7206	1.82151957464e-25
ko05033	Nicotine addiction	40/858	56/7206	2.99630890211e-25
ko04721	Synaptic vesicle cycle	43/858	80/7206	7.71103581561e-20
ko04728	Dopaminergic synapse	69/858	185/7206	1.41569949326e-19
ko05032	Morphine addiction	49/858	110/7206	5.9024467583e-18
ko04727	GABAergic synapse	47/858	110/7206	2.16949537691e-16
ko04713	Circadian entrainment	53/858	136/7206	3.08388440647e-16
ko04723	Retrograde endocannabinoid signaling	60/858	175/7206	3.59728576936e-15
ko04725	Cholinergic synapse	55/858	160/7206	4.68428374407e-14
ko04911	Insulin secretion	42/858	117/7206	9.96545122408e-12
ko04020	Calcium signaling pathway	71/858	265/7206	1.23817756818e-11
ko04726	Serotonergic synapse	46/858	137/7206	1.51025265857e-11
ko04024	cAMP signaling pathway	73/858	279/7206	2.20451843501e-11
ko04921	Oxytocin signaling pathway	59/858	209/7206	7.26917401015e-11
ko05031	Amphetamine addiction	34/858	91/7206	2.78693690236e-10
ko04261	Adrenergic signaling in cardiomyocytes	57/858	205/7206	3.8962206694e-10
ko04742	Taste transduction	26/858	61/7206	1.29758523246e-09
ko04720	Long-term potentiation	31/858	99/7206	2.01853121947e-07
ko04966	Collecting duct acid secretion	14/858	26/7206	2.52446859226e-07
ko04970	Salivary secretion	30/858	95/7206	2.57954586654e-07
ko03040	Spliceosome	1/858	145/7206	3.53758471326e-07
ko05030	Cocaine addiction	25/858	73/7206	4.62511128089e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	25/858	74/7206	6.20959267882e-07
ko04120	Ubiquitin mediated proteolysis	1/858	138/7206	7.9638042314e-07
ko05203	Viral carcinogenesis	10/858	277/7206	1.55635308942e-06
ko04010	MAPK signaling pathway	67/858	321/7206	2.42799159017e-06
ko04514	Cell adhesion molecules (CAMs)	35/858	130/7206	3.03656585728e-06
ko05322	Systemic lupus erythematosus	3/858	151/7206	1.09327732402e-05
ko05168	Herpes simplex infection	5/858	182/7206	1.28095030587e-05
ko05164	Influenza A	4/858	167/7206	1.54280003789e-05
ko04060	Cytokine-cytokine receptor interaction	6/858	191/7206	2.14837591545e-05
ko04971	Gastric acid secretion	26/858	98/7206	5.58990642363e-05
ko03013	RNA transport	5/858	166/7206	7.84152232802e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	22/858	79/7206	0.000131131662749
ko04621	NOD-like receptor signaling pathway	5/858	157/7206	0.000152322474856
ko04022	cGMP-PKG signaling pathway	45/858	216/7206	0.000156192143779
ko04141	Protein processing in endoplasmic reticulum	7/858	184/7206	0.000184427202077
ko04730	Long-term depression	21/858	78/7206	0.000263387395704
ko05110	Vibrio cholerae infection	18/858	63/7206	0.0002696164128
ko04360	Axon guidance	47/858	233/7206	0.000273756628317
ko04745	Phototransduction - fly	13/858	38/7206	0.000274827826091
ko04260	Cardiac muscle contraction	24/858	98/7206	0.000430600035588
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/858	14/7206	0.000532900283975
ko04972	Pancreatic secretion	26/858	111/7206	0.000553886547054
ko04924	Renin secretion	22/858	86/7206	0.000559948408715
ko04925	Aldosterone synthesis and secretion	25/858	105/7206	0.000632125566421
ko03008	Ribosome biogenesis in eukaryotes	1/858	79/7206	0.000759471143606
ko04612	Antigen processing and presentation	1/858	77/7206	0.00113390529191
ko05162	Measles	4/858	120/7206	0.0015360966583
ko05205	Proteoglycans in cancer	17/858	271/7206	0.00215541888271
ko04744	Phototransduction	11/858	36/7206	0.00229719963849
ko04014	Ras signaling pathway	50/858	279/7206	0.00248140474211
ko04740	Olfactory transduction	19/858	80/7206	0.00263093886184
ko04064	NF-kappa B signaling pathway	3/858	96/7206	0.00389559973908
ko05161	Hepatitis B	9/858	173/7206	0.0040421673428
ko05414	Dilated cardiomyopathy	24/858	112/7206	0.00454073036565
ko04964	Proximal tubule bicarbonate reclamation	9/858	29/7206	0.0050546984634
ko05166	HTLV-I infection	20/858	292/7206	0.00542222110378
ko00561	Glycerolipid metabolism	1/858	63/7206	0.00544816047744
ko04540	Gap junction	26/858	128/7206	0.00546780605213
ko04640	Hematopoietic cell lineage	1/858	64/7206	0.00554681431278
ko04110	Cell cycle	7/858	145/7206	0.00599674790762
ko05410	Hypertrophic cardiomyopathy (HCM)	21/858	100/7206	0.00779795798629
ko04146	Peroxisome	3/858	89/7206	0.00781765576125
ko00330	Arginine and proline metabolism	1/858	61/7206	0.00829434229387
ko05120	Epithelial cell signaling in Helicobacter pylori infection	20/858	92/7206	0.00836771614194
ko04214	Apoptosis - fly	2/858	72/7206	0.00996391603482
ko05016	Huntington's disease	14/858	215/7206	0.0101775812688
ko05140	Leishmaniasis	2/858	75/7206	0.0105154827233
ko00240	Pyrimidine metabolism	5/858	110/7206	0.0114325331602
ko05169	Epstein-Barr virus infection	13/858	206/7206	0.0115018990902
ko05321	Inflammatory bowel disease (IBD)	1/858	56/7206	0.011857608571
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/858	59/7206	0.0130031875682
ko04630	Jak-STAT signaling pathway	7/858	132/7206	0.0142444800058
ko04626	Plant-pathogen interaction	6/858	18/7206	0.0146935822096
ko00590	Arachidonic acid metabolism	1/858	52/7206	0.017443952233
ko00280	Valine, leucine and isoleucine degradation	1/858	54/7206	0.0179101446728
ko00480	Glutathione metabolism	1/858	55/7206	0.018578876766
ko04750	Inflammatory mediator regulation of TRP channels	23/858	122/7206	0.0231866889972
ko04371	Apelin signaling pathway	31/858	177/7206	0.0250391029966
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/858	182/7206	0.0267060485106
ko04915	Estrogen signaling pathway	24/858	131/7206	0.0286026433881
ko04330	Notch signaling pathway	2/858	62/7206	0.0291983193176
ko01524	Platinum drug resistance	3/858	76/7206	0.030672800798
ko04217	Necroptosis	12/858	178/7206	0.033910418115
ko04976	Bile secretion	16/858	80/7206	0.0351027516806
ko05010	Alzheimer's disease	34/858	202/7206	0.0355555552061
ko05215	Prostate cancer	6/858	111/7206	0.036915807836
ko04611	Platelet activation	11/858	163/7206	0.0374071558862
ko05144	Malaria	1/858	45/7206	0.0375959606558
ko00071	Fatty acid degradation	1/858	45/7206	0.0375959606558
ko04070	Phosphatidylinositol signaling system	21/858	112/7206	0.037660353099
ko00620	Pyruvate metabolism	1/858	46/7206	0.0377373096536
ko03420	Nucleotide excision repair	1/858	46/7206	0.0377373096536
ko00260	Glycine, serine and threonine metabolism	1/858	48/7206	0.0397009811835
ko05220	Chronic myeloid leukemia	4/858	85/7206	0.041304044201
ko00310	Lysine degradation	3/858	73/7206	0.0430488126833
ko04668	TNF signaling pathway	7/858	120/7206	0.0448268287258
ko05323	Rheumatoid arthritis	17/858	89/7206	0.0461457002162
ko04916	Melanogenesis	25/858	142/7206	0.0480760359465
ko04391	Hippo signaling pathway - fly	17/858	90/7206	0.0481728967829