ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1123	423/7206	2.54382457782e-49
ko04724	Glutamatergic synapse	85/1123	152/7206	5.47653787728e-31
ko05033	Nicotine addiction	46/1123	56/7206	2.39874757874e-28
ko05032	Morphine addiction	63/1123	110/7206	5.5949546958e-24
ko04713	Circadian entrainment	69/1123	136/7206	4.84188512712e-22
ko04721	Synaptic vesicle cycle	49/1123	80/7206	1.15613790097e-20
ko04727	GABAergic synapse	59/1123	110/7206	1.42143494814e-20
ko04728	Dopaminergic synapse	79/1123	185/7206	3.59282925798e-19
ko04725	Cholinergic synapse	71/1123	160/7206	1.87680768719e-18
ko04723	Retrograde endocannabinoid signaling	72/1123	175/7206	1.67332206157e-16
ko04911	Insulin secretion	55/1123	117/7206	6.59420917162e-16
ko04024	cAMP signaling pathway	96/1123	279/7206	2.18931509902e-15
ko04020	Calcium signaling pathway	92/1123	265/7206	4.14319803331e-15
ko04921	Oxytocin signaling pathway	75/1123	209/7206	2.3067443926e-13
ko04742	Taste transduction	34/1123	61/7206	4.93854162072e-13
ko04726	Serotonergic synapse	54/1123	137/7206	8.54387197737e-12
ko05031	Amphetamine addiction	41/1123	91/7206	1.93571539486e-11
ko04970	Salivary secretion	40/1123	95/7206	4.32663857067e-10
ko04720	Long-term potentiation	41/1123	99/7206	4.82280780435e-10
ko04261	Adrenergic signaling in cardiomyocytes	67/1123	205/7206	5.51133162511e-10
ko04744	Phototransduction	22/1123	36/7206	6.02678291811e-10
ko04925	Aldosterone synthesis and secretion	41/1123	105/7206	3.97436856349e-09
ko03040	Spliceosome	2/1123	145/7206	1.03239473063e-08
ko04740	Olfactory transduction	32/1123	80/7206	1.05086024433e-07
ko05203	Viral carcinogenesis	15/1123	277/7206	1.74344133644e-07
ko04971	Gastric acid secretion	36/1123	98/7206	2.73281553428e-07
ko05168	Herpes simplex infection	7/1123	182/7206	7.01310999147e-07
ko04966	Collecting duct acid secretion	15/1123	26/7206	1.00181353585e-06
ko05030	Cocaine addiction	28/1123	73/7206	1.79206918856e-06
ko05322	Systemic lupus erythematosus	5/1123	151/7206	2.03527170713e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1123	74/7206	2.46089940456e-06
ko04360	Axon guidance	63/1123	233/7206	5.2759546127e-06
ko03013	RNA transport	7/1123	166/7206	6.19319788682e-06
ko04022	cGMP-PKG signaling pathway	59/1123	216/7206	8.93411700016e-06
ko04120	Ubiquitin mediated proteolysis	5/1123	138/7206	1.33617637434e-05
ko04621	NOD-like receptor signaling pathway	7/1123	157/7206	1.75033943107e-05
ko04514	Cell adhesion molecules (CAMs)	39/1123	130/7206	2.54745357501e-05
ko04972	Pancreatic secretion	35/1123	111/7206	2.74956181454e-05
ko04010	MAPK signaling pathway	78/1123	321/7206	3.70206832048e-05
ko05164	Influenza A	9/1123	167/7206	5.57711303237e-05
ko04745	Phototransduction - fly	16/1123	38/7206	8.01829651968e-05
ko04730	Long-term depression	26/1123	78/7206	9.98745883042e-05
ko04060	Cytokine-cytokine receptor interaction	12/1123	191/7206	0.000106848446317
ko04540	Gap junction	37/1123	128/7206	0.000108908810499
ko05110	Vibrio cholerae infection	22/1123	63/7206	0.000141863369487
ko04070	Phosphatidylinositol signaling system	33/1123	112/7206	0.000181246517002
ko04260	Cardiac muscle contraction	30/1123	98/7206	0.000190976793584
ko04750	Inflammatory mediator regulation of TRP channels	35/1123	122/7206	0.000207896019541
ko03008	Ribosome biogenesis in eukaryotes	2/1123	79/7206	0.000269189587133
ko04141	Protein processing in endoplasmic reticulum	12/1123	184/7206	0.000272115402745
ko04110	Cell cycle	8/1123	145/7206	0.000283877563003
ko04014	Ras signaling pathway	66/1123	279/7206	0.000371238767377
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1123	79/7206	0.000430889885277
ko04924	Renin secretion	26/1123	86/7206	0.000496179286732
ko04072	Phospholipase D signaling pathway	49/1123	197/7206	0.000636632527409
ko04214	Apoptosis - fly	2/1123	72/7206	0.000871327027244
ko04915	Estrogen signaling pathway	35/1123	131/7206	0.000914241925678
ko05166	HTLV-I infection	26/1123	292/7206	0.000925494132482
ko04976	Bile secretion	24/1123	80/7206	0.000956187680523
ko05169	Epstein-Barr virus infection	16/1123	206/7206	0.00119056575945
ko04610	Complement and coagulation cascades	3/1123	79/7206	0.00156724910338
ko05414	Dilated cardiomyopathy	30/1123	112/7206	0.00223031548132
ko04612	Antigen processing and presentation	3/1123	77/7206	0.00228591235976
ko05205	Proteoglycans in cancer	25/1123	271/7206	0.00267812147971
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1123	14/7206	0.00274079726008
ko04964	Proximal tubule bicarbonate reclamation	11/1123	29/7206	0.00287872104361
ko00310	Lysine degradation	3/1123	73/7206	0.00325498879594
ko05140	Leishmaniasis	3/1123	75/7206	0.00336359380993
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1123	59/7206	0.00337312307546
ko04626	Plant-pathogen interaction	8/1123	18/7206	0.00343781015354
ko05161	Hepatitis B	14/1123	173/7206	0.00407113511427
ko04330	Notch signaling pathway	2/1123	62/7206	0.00412441405598
ko05219	Bladder cancer	1/1123	48/7206	0.00458263165145
ko05162	Measles	8/1123	120/7206	0.00484889888757
ko04710	Circadian rhythm	14/1123	43/7206	0.00491345505884
ko04922	Glucagon signaling pathway	32/1123	128/7206	0.00631762636059
ko00071	Fatty acid degradation	1/1123	45/7206	0.0068729620595
ko03420	Nucleotide excision repair	1/1123	46/7206	0.00690940566349
ko04146	Peroxisome	5/1123	89/7206	0.00735260107646
ko04064	NF-kappa B signaling pathway	6/1123	96/7206	0.00992821524643
ko03022	Basal transcription factors	1/1123	44/7206	0.0105378512506
ko04371	Apelin signaling pathway	40/1123	177/7206	0.0116914022816
ko00240	Pyrimidine metabolism	8/1123	110/7206	0.0117074777764
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1123	100/7206	0.0122483599941
ko00280	Valine, leucine and isoleucine degradation	2/1123	54/7206	0.0127590771822
ko04622	RIG-I-like receptor signaling pathway	3/1123	62/7206	0.0135674343204
ko05131	Shigellosis	5/1123	82/7206	0.0136929228664
ko04916	Melanogenesis	33/1123	142/7206	0.0140367048717
ko04923	Regulation of lipolysis in adipocytes	20/1123	77/7206	0.0169056597116
ko00590	Arachidonic acid metabolism	2/1123	52/7206	0.0189947919672
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1123	92/7206	0.019405458624
ko00330	Arginine and proline metabolism	3/1123	61/7206	0.019540650793
ko04630	Jak-STAT signaling pathway	11/1123	132/7206	0.0205936317877
ko04210	Apoptosis	17/1123	180/7206	0.0215111949269
ko04930	Type II diabetes mellitus	15/1123	54/7206	0.0216858656494
ko03410	Base excision repair	1/1123	38/7206	0.0229225519481
ko04657	IL-17 signaling pathway	6/1123	87/7206	0.024485792364
ko05133	Pertussis	6/1123	87/7206	0.024485792364
ko00562	Inositol phosphate metabolism	22/1123	89/7206	0.0259353559467
ko00260	Glycine, serine and threonine metabolism	2/1123	48/7206	0.0262630245578
ko05206	MicroRNAs in cancer	17/1123	177/7206	0.0269863908623
ko05217	Basal cell carcinoma	4/1123	68/7206	0.027250961679
ko04217	Necroptosis	17/1123	178/7206	0.0272739265619
ko04960	Aldosterone-regulated sodium reabsorption	12/1123	41/7206	0.0272986016664
ko04350	TGF-beta signaling pathway	8/1123	103/7206	0.0276128916584
ko05016	Huntington's disease	22/1123	215/7206	0.02777627339
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1123	182/7206	0.0297038365493
ko04973	Carbohydrate digestion and absorption	12/1123	42/7206	0.0301536815236
ko04912	GnRH signaling pathway	28/1123	122/7206	0.0313945874154
ko03018	RNA degradation	6/1123	84/7206	0.0328531162247
ko04114	Oocyte meiosis	31/1123	139/7206	0.0330819371047
ko05145	Toxoplasmosis	11/1123	126/7206	0.0342371242443
ko04918	Thyroid hormone synthesis	21/1123	86/7206	0.0345526988649
ko00512	Mucin type O-glycan biosynthesis	9/1123	29/7206	0.0350499099638
ko04115	p53 signaling pathway	5/1123	74/7206	0.0351085155481
ko04015	Rap1 signaling pathway	56/1123	278/7206	0.0351163395165
ko05144	Malaria	2/1123	45/7206	0.0376175228771
ko04550	Signaling pathways regulating pluripotency of stem cells	16/1123	165/7206	0.0383113873595
ko00480	Glutathione metabolism	3/1123	55/7206	0.0383259455749
ko05321	Inflammatory bowel disease (IBD)	3/1123	56/7206	0.0392449489484
ko04962	Vasopressin-regulated water reabsorption	15/1123	58/7206	0.0430510298547
ko05200	Pathways in cancer	61/1123	492/7206	0.045731710511
ko04658	Th1 and Th2 cell differentiation	8/1123	96/7206	0.0473488653275
ko04978	Mineral absorption	11/1123	40/7206	0.0473604323711