ko pathway ratio_in_study ratio_in_pop p_value ko05322 Systemic lupus erythematosus 42/327 151/7206 1.53265933834e-22 ko03440 Homologous recombination 19/327 41/7206 1.77975160753e-15 ko05034 Alcoholism 43/327 238/7206 2.06959492612e-15 ko04110 Cell cycle 31/327 145/7206 2.03340105432e-13 ko03460 Fanconi anemia pathway 19/327 51/7206 2.32574009287e-13 ko04111 Cell cycle - yeast 21/327 90/7206 3.21130394785e-10 ko05203 Viral carcinogenesis 36/327 277/7206 7.46954929954e-09 ko03040 Spliceosome 23/327 145/7206 1.19477392749e-07 ko04113 Meiosis - yeast 15/327 70/7206 3.8486188509e-07 ko03018 RNA degradation 16/327 84/7206 8.59476604421e-07 ko03013 RNA transport 21/327 166/7206 1.75224088007e-05 ko04151 PI3K-Akt signaling pathway 3/327 390/7206 2.4954093337e-05 ko03008 Ribosome biogenesis in eukaryotes 13/327 79/7206 4.77306337283e-05 ko05202 Transcriptional misregulation in cancer 21/327 188/7206 0.000112513841423 ko03022 Basal transcription factors 9/327 44/7206 0.000126734748035 ko03410 Base excision repair 8/327 38/7206 0.000244359783031 ko03030 DNA replication 8/327 38/7206 0.000244359783031 ko04020 Calcium signaling pathway 2/327 265/7206 0.000738992953704 ko04921 Oxytocin signaling pathway 1/327 209/7206 0.00108216869605 ko04114 Oocyte meiosis 15/327 139/7206 0.00151598340374 ko05010 Alzheimer's disease 1/327 202/7206 0.00160355767201 ko04060 Cytokine-cytokine receptor interaction 1/327 191/7206 0.00230559414921 ko03430 Mismatch repair 5/327 22/7206 0.00259439940539 ko04144 Endocytosis 5/327 342/7206 0.00300815998311 ko04217 Necroptosis 17/327 178/7206 0.00309483231407 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/327 182/7206 0.00335838660797 ko04728 Dopaminergic synapse 1/327 185/7206 0.00343028096496 ko05152 Tuberculosis 1/327 187/7206 0.0035205935337 ko04022 cGMP-PKG signaling pathway 2/327 216/7206 0.00436622095989 ko04723 Retrograde endocannabinoid signaling 1/327 175/7206 0.00493622368337 ko00310 Lysine degradation 9/327 73/7206 0.00546836930298 ko04140 Autophagy - animal 1/327 164/7206 0.00709322613482 ko04024 cAMP signaling pathway 4/327 279/7206 0.00751981596295 ko04218 Cellular senescence 16/327 177/7206 0.00875895632091 ko04072 Phospholipase D signaling pathway 2/327 197/7206 0.0088234136042 ko05166 HTLV-I infection 23/327 292/7206 0.00905762459928 ko05012 Parkinson's disease 1/327 155/7206 0.0102829817793 ko04725 Cholinergic synapse 1/327 160/7206 0.010676487425 ko04010 MAPK signaling pathway 6/327 321/7206 0.0133499499366 ko04724 Glutamatergic synapse 1/327 152/7206 0.0156117400969 ko05160 Hepatitis C 1/327 153/7206 0.0158487321566 ko03420 Nucleotide excision repair 6/327 46/7206 0.0168820098667 ko04210 Apoptosis 2/327 180/7206 0.0176208780721 ko04141 Protein processing in endoplasmic reticulum 2/327 184/7206 0.0179092769344 ko04115 p53 signaling pathway 8/327 74/7206 0.0183393590115 ko04014 Ras signaling pathway 5/327 279/7206 0.0186395252474 ko04713 Circadian entrainment 1/327 136/7206 0.0214833362208 ko04931 Insulin resistance 1/327 137/7206 0.0214901657362 ko04726 Serotonergic synapse 1/327 137/7206 0.0214901657362 ko05205 Proteoglycans in cancer 5/327 271/7206 0.0250354361121 ko04261 Adrenergic signaling in cardiomyocytes 3/327 205/7206 0.0260032918954 ko04510 Focal adhesion 4/327 240/7206 0.0260109738311 ko04914 Progesterone-mediated oocyte maturation 10/327 104/7206 0.026891187325 ko00190 Oxidative phosphorylation 1/327 127/7206 0.030966097031 ko04915 Estrogen signaling pathway 1/327 131/7206 0.0313577267621 ko04630 Jak-STAT signaling pathway 1/327 132/7206 0.0316100527235 ko04380 Osteoclast differentiation 1/327 134/7206 0.0322998028744 ko04810 Regulation of actin cytoskeleton 5/327 264/7206 0.0336398129882 ko04152 AMPK signaling pathway 2/327 161/7206 0.0347579297987 ko04071 Sphingolipid signaling pathway 2/327 162/7206 0.0347656986793 ko04611 Platelet activation 2/327 163/7206 0.0348269451917 ko04062 Chemokine signaling pathway 3/327 201/7206 0.0366018254609 ko04912 GnRH signaling pathway 1/327 122/7206 0.0450525238449 ko04750 Inflammatory mediator regulation of TRP channels 1/327 122/7206 0.0450525238449 ko04211 Longevity regulating pathway 1/327 123/7206 0.0453934732884 ko04066 HIF-1 signaling pathway 1/327 123/7206 0.0453934732884 ko05145 Toxoplasmosis 1/327 126/7206 0.0469161671321 ko04122 Sulfur relay system 2/327 8/7206 0.0479502053116