ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 42/460 191/7206 5.48150633941e-13 ko04380 Osteoclast differentiation 31/460 134/7206 1.76345812575e-10 ko05340 Primary immunodeficiency 14/460 30/7206 8.67844036256e-10 ko04610 Complement and coagulation cascades 20/460 79/7206 6.5442074186e-08 ko04650 Natural killer cell mediated cytotoxicity 21/460 97/7206 5.43057497409e-07 ko05145 Toxoplasmosis 24/460 126/7206 1.02454366125e-06 ko05150 Staphylococcus aureus infection 12/460 36/7206 1.21397465434e-06 ko04137 Mitophagy - animal 18/460 82/7206 2.86134590977e-06 ko05140 Leishmaniasis 17/460 75/7206 3.38952923419e-06 ko04621 NOD-like receptor signaling pathway 26/460 157/7206 5.70106227326e-06 ko05164 Influenza A 27/460 167/7206 6.00538242743e-06 ko05321 Inflammatory bowel disease (IBD) 14/460 56/7206 7.41076589464e-06 ko04620 Toll-like receptor signaling pathway 19/460 100/7206 1.43292735498e-05 ko00120 Primary bile acid biosynthesis 8/460 20/7206 1.65058086667e-05 ko05162 Measles 21/460 120/7206 1.92339294693e-05 ko04640 Hematopoietic cell lineage 14/460 64/7206 3.8086410621e-05 ko05320 Autoimmune thyroid disease 9/460 29/7206 5.15824067955e-05 ko05330 Allograft rejection 8/460 24/7206 7.67498459651e-05 ko04612 Antigen processing and presentation 15/460 77/7206 8.47063687374e-05 ko00140 Steroid hormone biosynthesis 10/460 41/7206 0.000189391689074 ko05167 Kaposi's sarcoma-associated herpesvirus infection 26/460 191/7206 0.000223012225005 ko05168 Herpes simplex infection 25/460 182/7206 0.000281149133395 ko03013 RNA transport 1/460 166/7206 0.000319779425882 ko04064 NF-kappa B signaling pathway 16/460 96/7206 0.000335086653456 ko04659 Th17 cell differentiation 17/460 106/7206 0.000353230267274 ko05152 Tuberculosis 25/460 187/7206 0.000373220916614 ko04630 Jak-STAT signaling pathway 20/460 132/7206 0.000393593011103 ko04672 Intestinal immune network for IgA production 9/460 37/7206 0.000405198197545 ko05332 Graft-versus-host disease 6/460 18/7206 0.000628051936824 ko04217 Necroptosis 23/460 178/7206 0.000985222466565 ko04310 Wnt signaling pathway 2/460 181/7206 0.000996935464046 ko05034 Alcoholism 4/460 238/7206 0.001017429589 ko04658 Th1 and Th2 cell differentiation 15/460 96/7206 0.00102463743658 ko04660 T cell receptor signaling pathway 18/460 124/7206 0.00108483654904 ko04062 Chemokine signaling pathway 25/460 201/7206 0.00111700078502 ko04662 B cell receptor signaling pathway 14/460 88/7206 0.00124846766088 ko00590 Arachidonic acid metabolism 10/460 52/7206 0.00141949877526 ko03040 Spliceosome 1/460 145/7206 0.00154469521792 ko05144 Malaria 9/460 45/7206 0.00182987142015 ko00982 Drug metabolism - cytochrome P450 8/460 37/7206 0.0019322318198 ko00480 Glutathione metabolism 10/460 55/7206 0.00221010575769 ko05418 Fluid shear stress and atherosclerosis 22/460 173/7206 0.00224071131819 ko05161 Hepatitis B 22/460 173/7206 0.00224071131819 ko03010 Ribosome 1/460 129/7206 0.0031724533225 ko05310 Asthma 5/460 17/7206 0.00337706646448 ko04390 Hippo signaling pathway 3/460 188/7206 0.00352243798737 ko00051 Fructose and mannose metabolism 8/460 42/7206 0.00446260669788 ko04145 Phagosome 20/460 162/7206 0.00479546980969 ko00592 alpha-Linolenic acid metabolism 5/460 19/7206 0.00570773241186 ko05224 Breast cancer 3/460 174/7206 0.00684084979069 ko04723 Retrograde endocannabinoid signaling 3/460 175/7206 0.00691299788387 ko04666 Fc gamma R-mediated phagocytosis 16/460 122/7206 0.00732745103083 ko01524 Platinum drug resistance 11/460 76/7206 0.00837361866744 ko04916 Melanogenesis 2/460 142/7206 0.0084805198073 ko04110 Cell cycle 2/460 145/7206 0.00875612232175 ko05204 Chemical carcinogenesis 8/460 48/7206 0.010208526279 ko00980 Metabolism of xenobiotics by cytochrome P450 7/460 40/7206 0.0122415352386 ko04146 Peroxisome 12/460 89/7206 0.0132518664848 ko05323 Rheumatoid arthritis 12/460 89/7206 0.0132518664848 ko04940 Type I diabetes mellitus 6/460 32/7206 0.0143355589679 ko04622 RIG-I-like receptor signaling pathway 9/460 62/7206 0.0160552160418 ko00350 Tyrosine metabolism 6/460 33/7206 0.0166050061228 ko04611 Platelet activation 18/460 163/7206 0.0216367380199 ko05133 Pertussis 11/460 87/7206 0.0249848491816 ko05160 Hepatitis C 17/460 153/7206 0.0273589661769 ko04664 Fc epsilon RI signaling pathway 10/460 77/7206 0.0298280109041 ko03015 mRNA surveillance pathway 1/460 93/7206 0.030147317073 ko04728 Dopaminergic synapse 5/460 185/7206 0.0327210855597 ko05132 Salmonella infection 12/460 98/7206 0.0331101444024 ko04911 Insulin secretion 2/460 117/7206 0.0338900738382 ko04530 Tight junction 7/460 228/7206 0.0377015593081 ko04623 Cytosolic DNA-sensing pathway 6/460 41/7206 0.0440008804714 ko05142 Chagas disease (American trypanosomiasis) 14/460 130/7206 0.0458868286237 ko05032 Morphine addiction 2/460 110/7206 0.0473234006293 ko04972 Pancreatic secretion 2/460 111/7206 0.0476454235107