ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 27/289 80/7206 1.32930810708e-18 ko04080 Neuroactive ligand-receptor interaction 57/289 423/7206 1.01838828899e-16 ko05033 Nicotine addiction 21/289 56/7206 8.59686905232e-16 ko04724 Glutamatergic synapse 31/289 152/7206 2.64818729074e-14 ko04727 GABAergic synapse 24/289 110/7206 5.49437882912e-12 ko04966 Collecting duct acid secretion 12/289 26/7206 8.07003014072e-11 ko04728 Dopaminergic synapse 29/289 185/7206 1.77566866776e-10 ko04713 Circadian entrainment 24/289 136/7206 6.04386126592e-10 ko04723 Retrograde endocannabinoid signaling 27/289 175/7206 1.12952504885e-09 ko05014 Amyotrophic lateral sclerosis (ALS) 17/289 74/7206 3.26628167313e-09 ko05032 Morphine addiction 20/289 110/7206 1.0110461117e-08 ko05110 Vibrio cholerae infection 15/289 63/7206 1.67065950205e-08 ko05030 Cocaine addiction 16/289 73/7206 1.97783086624e-08 ko04145 Phagosome 22/289 162/7206 4.2598652686e-07 ko04726 Serotonergic synapse 20/289 137/7206 4.46718394924e-07 ko05120 Epithelial cell signaling in Helicobacter pylori infection 16/289 92/7206 5.92964887497e-07 ko05323 Rheumatoid arthritis 15/289 89/7206 2.03180397904e-06 ko05031 Amphetamine addiction 15/289 91/7206 2.71515900708e-06 ko04911 Insulin secretion 17/289 117/7206 3.56219450046e-06 ko04725 Cholinergic synapse 20/289 160/7206 5.36106025753e-06 ko04024 cAMP signaling pathway 27/289 279/7206 2.58760539466e-05 ko04730 Long-term depression 12/289 78/7206 5.57698658289e-05 ko04970 Salivary secretion 13/289 95/7206 9.61299313191e-05 ko04720 Long-term potentiation 13/289 99/7206 0.000147579121878 ko00190 Oxidative phosphorylation 15/289 127/7206 0.000156948249872 ko04972 Pancreatic secretion 13/289 111/7206 0.000465650687464 ko04261 Adrenergic signaling in cardiomyocytes 19/289 205/7206 0.000742299161943 ko04921 Oxytocin signaling pathway 19/289 209/7206 0.000857390872802 ko04514 Cell adhesion molecules (CAMs) 13/289 130/7206 0.00205434319125 ko04961 Endocrine and other factor-regulated calcium reabsorption 8/289 59/7206 0.002269612021 ko04742 Taste transduction 8/289 61/7206 0.00281273351297 ko04964 Proximal tubule bicarbonate reclamation 5/289 29/7206 0.00538939880195 ko04971 Gastric acid secretion 10/289 98/7206 0.00569565914232 ko04924 Renin secretion 9/289 86/7206 0.007261870913 ko05034 Alcoholism 18/289 238/7206 0.0102025308181 ko05168 Herpes simplex infection 1/289 182/7206 0.0109020388689 ko05010 Alzheimer's disease 15/289 202/7206 0.0177240491703 ko04540 Gap junction 11/289 128/7206 0.0185354152424 ko00512 Mucin type O-glycan biosynthesis 4/289 29/7206 0.0273010018397 ko04010 MAPK signaling pathway 21/289 321/7206 0.0273839527571 ko03040 Spliceosome 1/289 145/7206 0.0312350221246 ko05322 Systemic lupus erythematosus 1/289 151/7206 0.0323450940367 ko04940 Type I diabetes mellitus 4/289 32/7206 0.0376642972757 ko04360 Axon guidance 16/289 233/7206 0.0387039546892 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/289 1/7206 0.0401054676659 ko04915 Estrogen signaling pathway 10/289 131/7206 0.0416871343556 ko04014 Ras signaling pathway 18/289 279/7206 0.0418953813464 ko05166 HTLV-I infection 5/289 292/7206 0.0455671054736 ko00680 Methane metabolism 4/289 34/7206 0.0456654673189 ko04217 Necroptosis 2/289 178/7206 0.0497692989561