ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	206/1232	423/7206	1.34801525412e-54
ko04724	Glutamatergic synapse	93/1232	152/7206	7.07192296211e-35
ko05033	Nicotine addiction	50/1232	56/7206	2.15344910152e-32
ko05032	Morphine addiction	71/1232	110/7206	6.12874109092e-29
ko04713	Circadian entrainment	79/1232	136/7206	1.43861853281e-27
ko04727	GABAergic synapse	68/1232	110/7206	4.11452852684e-26
ko04721	Synaptic vesicle cycle	52/1232	80/7206	1.07870197353e-21
ko04728	Dopaminergic synapse	86/1232	185/7206	5.00171734609e-21
ko04725	Cholinergic synapse	78/1232	160/7206	9.52761991696e-21
ko04723	Retrograde endocannabinoid signaling	80/1232	175/7206	4.48983269086e-19
ko04020	Calcium signaling pathway	104/1232	265/7206	2.16138267082e-18
ko04024	cAMP signaling pathway	107/1232	279/7206	4.84403585206e-18
ko04911	Insulin secretion	59/1232	117/7206	7.48292809816e-17
ko04742	Taste transduction	39/1232	61/7206	3.29255784097e-16
ko04726	Serotonergic synapse	63/1232	137/7206	2.04472383397e-15
ko04744	Phototransduction	27/1232	36/7206	2.94657592034e-14
ko04921	Oxytocin signaling pathway	80/1232	209/7206	1.10257678185e-13
ko04740	Olfactory transduction	42/1232	80/7206	3.92089684719e-13
ko04720	Long-term potentiation	48/1232	99/7206	4.07936204852e-13
ko05031	Amphetamine addiction	45/1232	91/7206	9.18582415438e-13
ko04970	Salivary secretion	44/1232	95/7206	2.78373304325e-11
ko03040	Spliceosome	1/1232	145/7206	7.21330818676e-11
ko04261	Adrenergic signaling in cardiomyocytes	72/1232	205/7206	3.21738431939e-10
ko04360	Axon guidance	76/1232	233/7206	4.46681406547e-09
ko04925	Aldosterone synthesis and secretion	43/1232	105/7206	7.83411971903e-09
ko05168	Herpes simplex infection	7/1232	182/7206	4.0606315447e-08
ko05030	Cocaine addiction	32/1232	73/7206	7.35284945839e-08
ko04971	Gastric acid secretion	39/1232	98/7206	8.01569605472e-08
ko04022	cGMP-PKG signaling pathway	68/1232	216/7206	1.70105745467e-07
ko05203	Viral carcinogenesis	18/1232	277/7206	2.06727000641e-07
ko04540	Gap junction	46/1232	128/7206	2.92888646241e-07
ko03013	RNA transport	7/1232	166/7206	5.71303392002e-07
ko04060	Cytokine-cytokine receptor interaction	10/1232	191/7206	1.2146909482e-06
ko04972	Pancreatic secretion	40/1232	111/7206	1.30410082962e-06
ko04120	Ubiquitin mediated proteolysis	5/1232	138/7206	1.69544419179e-06
ko04621	NOD-like receptor signaling pathway	7/1232	157/7206	1.70903851326e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1232	74/7206	2.315574518e-06
ko04966	Collecting duct acid secretion	15/1232	26/7206	3.37689920217e-06
ko05322	Systemic lupus erythematosus	7/1232	151/7206	5.13269508608e-06
ko04924	Renin secretion	32/1232	86/7206	7.55507580149e-06
ko04514	Cell adhesion molecules (CAMs)	43/1232	130/7206	8.75383668425e-06
ko05164	Influenza A	9/1232	167/7206	9.07435455038e-06
ko04010	MAPK signaling pathway	86/1232	321/7206	9.21549122756e-06
ko04141	Protein processing in endoplasmic reticulum	11/1232	184/7206	9.7650087642e-06
ko04070	Phosphatidylinositol signaling system	38/1232	112/7206	1.18983108344e-05
ko04730	Long-term depression	29/1232	78/7206	2.32575820285e-05
ko04110	Cell cycle	8/1232	145/7206	4.68971436323e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1232	122/7206	4.77096185199e-05
ko04745	Phototransduction - fly	17/1232	38/7206	6.33848710254e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1232	79/7206	6.76425805658e-05
ko04612	Antigen processing and presentation	2/1232	77/7206	0.000107617626335
ko03008	Ribosome biogenesis in eukaryotes	2/1232	79/7206	0.000113023622108
ko05169	Epstein-Barr virus infection	16/1232	206/7206	0.000149580049694
ko04014	Ras signaling pathway	72/1232	279/7206	0.000176268647887
ko04260	Cardiac muscle contraction	32/1232	98/7206	0.000195766173124
ko05414	Dilated cardiomyopathy	35/1232	112/7206	0.000198785482775
ko04976	Bile secretion	27/1232	80/7206	0.000256826501655
ko05110	Vibrio cholerae infection	23/1232	63/7206	0.00026422001109
ko05162	Measles	7/1232	120/7206	0.000341397918206
ko04923	Regulation of lipolysis in adipocytes	26/1232	77/7206	0.00034670667531
ko04610	Complement and coagulation cascades	3/1232	79/7206	0.000462470443234
ko05205	Proteoglycans in cancer	26/1232	271/7206	0.000515354700978
ko04146	Peroxisome	4/1232	89/7206	0.00054967556208
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1232	59/7206	0.000666998234498
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1232	14/7206	0.000809466134547
ko04064	NF-kappa B signaling pathway	5/1232	96/7206	0.000880104535937
ko05140	Leishmaniasis	3/1232	75/7206	0.000989465850943
ko04072	Phospholipase D signaling pathway	52/1232	197/7206	0.00100994998126
ko00240	Pyrimidine metabolism	7/1232	110/7206	0.00129164656113
ko04964	Proximal tubule bicarbonate reclamation	12/1232	29/7206	0.00176240219055
ko04371	Apelin signaling pathway	46/1232	177/7206	0.0023355680193
ko03420	Nucleotide excision repair	1/1232	46/7206	0.00282125024532
ko04915	Estrogen signaling pathway	36/1232	131/7206	0.00310812880272
ko00480	Glutathione metabolism	2/1232	55/7206	0.00374431898115
ko05145	Toxoplasmosis	10/1232	126/7206	0.00397395498934
ko05161	Hepatitis B	16/1232	173/7206	0.00405765630199
ko03022	Basal transcription factors	1/1232	44/7206	0.00425087512509
ko05144	Malaria	1/1232	45/7206	0.00436965452979
ko00071	Fatty acid degradation	1/1232	45/7206	0.00436965452979
ko00310	Lysine degradation	4/1232	73/7206	0.00467025038102
ko05131	Shigellosis	5/1232	82/7206	0.00479852024073
ko04630	Jak-STAT signaling pathway	11/1232	132/7206	0.00491895761366
ko00280	Valine, leucine and isoleucine degradation	2/1232	54/7206	0.00557624288243
ko04626	Plant-pathogen interaction	8/1232	18/7206	0.00620019715897
ko04622	RIG-I-like receptor signaling pathway	3/1232	62/7206	0.00622856818191
ko00140	Steroid hormone biosynthesis	1/1232	41/7206	0.00642003672659
ko04214	Apoptosis - fly	4/1232	72/7206	0.00671194305341
ko05166	HTLV-I infection	33/1232	292/7206	0.00679159773158
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1232	182/7206	0.00697548872709
ko05418	Fluid shear stress and atherosclerosis	17/1232	173/7206	0.00781340682779
ko00590	Arachidonic acid metabolism	2/1232	52/7206	0.00831801102786
ko05133	Pertussis	6/1232	87/7206	0.00918786999624
ko00330	Arginine and proline metabolism	3/1232	61/7206	0.00922389397971
ko04015	Rap1 signaling pathway	64/1232	278/7206	0.00924378025916
ko04930	Type II diabetes mellitus	17/1232	54/7206	0.00965008078993
ko00562	Inositol phosphate metabolism	25/1232	89/7206	0.00992282954482
ko04912	GnRH signaling pathway	32/1232	122/7206	0.0103654270999
ko00260	Glycine, serine and threonine metabolism	2/1232	48/7206	0.0117297853393
ko03018	RNA degradation	6/1232	84/7206	0.0124884640519
ko04115	p53 signaling pathway	5/1232	74/7206	0.0129399357284
ko00630	Glyoxylate and dicarboxylate metabolism	1/1232	38/7206	0.015031090762
ko04210	Apoptosis	19/1232	180/7206	0.0160050642224
ko04270	Vascular smooth muscle contraction	38/1232	154/7206	0.0167100136662
ko00600	Sphingolipid metabolism	4/1232	63/7206	0.018305663375
ko05321	Inflammatory bowel disease (IBD)	3/1232	56/7206	0.0187393199295
ko04668	TNF signaling pathway	11/1232	120/7206	0.019481853558
ko04658	Th1 and Th2 cell differentiation	8/1232	96/7206	0.0197272842481
ko04217	Necroptosis	19/1232	178/7206	0.0200980608628
ko04960	Aldosterone-regulated sodium reabsorption	13/1232	41/7206	0.0201451317971
ko04918	Thyroid hormone synthesis	23/1232	86/7206	0.0210227822589
ko04657	IL-17 signaling pathway	7/1232	87/7206	0.0214017231719
ko05215	Prostate cancer	10/1232	111/7206	0.0215488033687
ko00640	Propanoate metabolism	1/1232	34/7206	0.0216236827705
ko00500	Starch and sucrose metabolism	1/1232	35/7206	0.0219541967183
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1232	100/7206	0.0224150699758
ko04973	Carbohydrate digestion and absorption	13/1232	42/7206	0.0231113955713
ko04916	Melanogenesis	35/1232	142/7206	0.0235585910332
ko04350	TGF-beta signaling pathway	9/1232	103/7206	0.0240458034343
ko04330	Notch signaling pathway	4/1232	62/7206	0.0259482031272
ko05231	Choline metabolism in cancer	33/1232	134/7206	0.0269234014319
ko01524	Platinum drug resistance	6/1232	76/7206	0.0311829895297
ko04620	Toll-like receptor signaling pathway	9/1232	100/7206	0.0313945241914
ko00983	Drug metabolism - other enzymes	2/1232	42/7206	0.0368671200358
ko05132	Salmonella infection	9/1232	98/7206	0.041394886448
ko04640	Hematopoietic cell lineage	5/1232	64/7206	0.0455332553644
ko04062	Chemokine signaling pathway	45/1232	201/7206	0.0461765497578
ko05320	Autoimmune thyroid disease	1/1232	29/7206	0.0481795656947
ko05340	Primary immunodeficiency	1/1232	30/7206	0.0487336478697