ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 127/843 423/7206 6.23629580661e-26 ko04724 Glutamatergic synapse 68/843 152/7206 4.15818080453e-25 ko05033 Nicotine addiction 39/843 56/7206 2.81741692985e-24 ko04721 Synaptic vesicle cycle 43/843 80/7206 3.85729174649e-20 ko05032 Morphine addiction 51/843 110/7206 6.26791675175e-20 ko04728 Dopaminergic synapse 66/843 185/7206 5.31173642434e-18 ko04727 GABAergic synapse 48/843 110/7206 1.76107668868e-17 ko04713 Circadian entrainment 53/843 136/7206 1.42436004148e-16 ko04723 Retrograde endocannabinoid signaling 60/843 175/7206 1.56948640239e-15 ko04725 Cholinergic synapse 56/843 160/7206 5.13334124262e-15 ko04024 cAMP signaling pathway 75/843 279/7206 1.28986834351e-12 ko04921 Oxytocin signaling pathway 58/843 209/7206 1.09935592653e-10 ko04911 Insulin secretion 38/843 117/7206 1.62183939201e-09 ko05031 Amphetamine addiction 32/843 91/7206 3.50610131502e-09 ko04726 Serotonergic synapse 41/843 137/7206 5.70587206191e-09 ko04261 Adrenergic signaling in cardiomyocytes 53/843 205/7206 1.31092419027e-08 ko04360 Axon guidance 57/843 233/7206 3.30788602549e-08 ko04744 Phototransduction 17/843 36/7206 1.21606868659e-07 ko04720 Long-term potentiation 31/843 99/7206 1.34918563478e-07 ko05203 Viral carcinogenesis 9/843 277/7206 4.92603787327e-07 ko03040 Spliceosome 1/843 145/7206 5.70417318247e-07 ko04742 Taste transduction 22/843 61/7206 6.06029919344e-07 ko04020 Calcium signaling pathway 58/843 265/7206 1.36333844302e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 24/843 74/7206 1.74122547941e-06 ko04970 Salivary secretion 28/843 95/7206 2.12938051002e-06 ko05030 Cocaine addiction 23/843 73/7206 4.98267326989e-06 ko04514 Cell adhesion molecules (CAMs) 34/843 130/7206 5.14542197377e-06 ko04060 Cytokine-cytokine receptor interaction 5/843 191/7206 6.31530413814e-06 ko04120 Ubiquitin mediated proteolysis 2/843 138/7206 1.12269656139e-05 ko05168 Herpes simplex infection 5/843 182/7206 1.87706242267e-05 ko04022 cGMP-PKG signaling pathway 46/843 216/7206 3.74288333021e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 8/843 14/7206 5.33670703981e-05 ko04730 Long-term depression 22/843 78/7206 5.51007953584e-05 ko03013 RNA transport 5/843 166/7206 7.69726468859e-05 ko04966 Collecting duct acid secretion 11/843 26/7206 7.69984862673e-05 ko05322 Systemic lupus erythematosus 4/843 151/7206 9.34435501821e-05 ko04924 Renin secretion 23/843 86/7206 0.000114216514322 ko04745 Phototransduction - fly 13/843 38/7206 0.000230101901199 ko04010 MAPK signaling pathway 59/843 321/7206 0.000345248409595 ko04925 Aldosterone synthesis and secretion 25/843 105/7206 0.000566244165594 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/843 79/7206 0.000625414662655 ko05169 Epstein-Barr virus infection 10/843 206/7206 0.000897230697145 ko05164 Influenza A 7/843 167/7206 0.000930256027601 ko04621 NOD-like receptor signaling pathway 6/843 157/7206 0.000934558825059 ko04612 Antigen processing and presentation 1/843 77/7206 0.00114179892465 ko03008 Ribosome biogenesis in eukaryotes 1/843 79/7206 0.00116467947624 ko04971 Gastric acid secretion 23/843 98/7206 0.00119856716479 ko04141 Protein processing in endoplasmic reticulum 9/843 184/7206 0.00229188082679 ko04740 Olfactory transduction 19/843 80/7206 0.0023061751336 ko04972 Pancreatic secretion 24/843 111/7206 0.00252309081032 ko04626 Plant-pathogen interaction 7/843 18/7206 0.00290422709608 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/843 59/7206 0.00322486663773 ko05205 Proteoglycans in cancer 17/843 271/7206 0.00364187362665 ko04540 Gap junction 26/843 128/7206 0.00491803202695 ko04640 Hematopoietic cell lineage 1/843 64/7206 0.00549338480669 ko04064 NF-kappa B signaling pathway 3/843 96/7206 0.00574358791791 ko04915 Estrogen signaling pathway 26/843 131/7206 0.00576181306879 ko04630 Jak-STAT signaling pathway 6/843 132/7206 0.00609606526973 ko05162 Measles 5/843 120/7206 0.00612226826736 ko00330 Arginine and proline metabolism 1/843 61/7206 0.0081521362821 ko00561 Glycerolipid metabolism 1/843 63/7206 0.00867825776528 ko04071 Sphingolipid signaling pathway 30/843 162/7206 0.00916410149894 ko05140 Leishmaniasis 2/843 75/7206 0.0102015365914 ko04260 Cardiac muscle contraction 20/843 98/7206 0.0108238921873 ko04146 Peroxisome 3/843 89/7206 0.0114741056051 ko05161 Hepatitis B 10/843 173/7206 0.0115273803701 ko04391 Hippo signaling pathway - fly 19/843 90/7206 0.0118448545329 ko05166 HTLV-I infection 21/843 292/7206 0.0119859742912 ko05010 Alzheimer's disease 35/843 202/7206 0.0145297128984 ko04214 Apoptosis - fly 2/843 72/7206 0.0148127944837 ko04964 Proximal tubule bicarbonate reclamation 8/843 29/7206 0.0154219277031 ko00240 Pyrimidine metabolism 5/843 110/7206 0.0158174320715 ko05110 Vibrio cholerae infection 14/843 63/7206 0.0160819446573 ko04070 Phosphatidylinositol signaling system 22/843 112/7206 0.016421005876 ko04014 Ras signaling pathway 46/843 279/7206 0.0170443185243 ko00280 Valine, leucine and isoleucine degradation 1/843 54/7206 0.0176716593853 ko04110 Cell cycle 8/843 145/7206 0.0179419858926 ko00520 Amino sugar and nucleotide sugar metabolism 1/843 55/7206 0.0180591740822 ko00480 Glutathione metabolism 1/843 55/7206 0.0180591740822 ko05321 Inflammatory bowel disease (IBD) 1/843 56/7206 0.0187290955226 ko04371 Apelin signaling pathway 31/843 177/7206 0.0235092058309 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/843 15/7206 0.0238351443722 ko05414 Dilated cardiomyopathy 21/843 112/7206 0.0254713429347 ko00590 Arachidonic acid metabolism 1/843 52/7206 0.0269265776394 ko05410 Hypertrophic cardiomyopathy (HCM) 19/843 100/7206 0.0278858504075 ko04930 Type II diabetes mellitus 12/843 54/7206 0.0296102073227 ko01524 Platinum drug resistance 3/843 76/7206 0.0304465626812 ko05145 Toxoplasmosis 7/843 126/7206 0.0343706513557 ko03420 Nucleotide excision repair 1/843 46/7206 0.0377906784526 ko05219 Bladder cancer 1/843 48/7206 0.0388226750309 ko05146 Amoebiasis 5/843 99/7206 0.0391774330902