ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	191/1160	423/7206	2.0192883425e-48
ko04724	Glutamatergic synapse	86/1160	152/7206	8.91630510963e-31
ko05033	Nicotine addiction	46/1160	56/7206	1.03483315216e-27
ko05032	Morphine addiction	64/1160	110/7206	4.60093400058e-24
ko04713	Circadian entrainment	71/1160	136/7206	9.49287124904e-23
ko04727	GABAergic synapse	62/1160	110/7206	2.48601889462e-22
ko04721	Synaptic vesicle cycle	51/1160	80/7206	5.97371947768e-22
ko04728	Dopaminergic synapse	83/1160	185/7206	7.70469424883e-21
ko04725	Cholinergic synapse	72/1160	160/7206	2.64928744168e-18
ko04024	cAMP signaling pathway	101/1160	279/7206	6.3714374864e-17
ko04723	Retrograde endocannabinoid signaling	74/1160	175/7206	6.41632983255e-17
ko04020	Calcium signaling pathway	94/1160	265/7206	4.17416010315e-15
ko04742	Taste transduction	36/1160	61/7206	2.45946357459e-14
ko04921	Oxytocin signaling pathway	77/1160	209/7206	1.80529819007e-13
ko04744	Phototransduction	25/1160	36/7206	1.16387938581e-12
ko04911	Insulin secretion	51/1160	117/7206	1.18462734551e-12
ko04726	Serotonergic synapse	56/1160	137/7206	2.32080236041e-12
ko04261	Adrenergic signaling in cardiomyocytes	71/1160	205/7206	5.01418789132e-11
ko05031	Amphetamine addiction	40/1160	91/7206	2.42925285044e-10
ko03040	Spliceosome	1/1160	145/7206	3.1523868096e-10
ko04720	Long-term potentiation	42/1160	99/7206	3.37148410629e-10
ko04970	Salivary secretion	39/1160	95/7206	4.53158113686e-09
ko05203	Viral carcinogenesis	14/1160	277/7206	1.40656284799e-08
ko05168	Herpes simplex infection	7/1160	182/7206	3.20537535311e-07
ko04060	Cytokine-cytokine receptor interaction	8/1160	191/7206	3.70444047705e-07
ko04925	Aldosterone synthesis and secretion	37/1160	105/7206	1.32110669649e-06
ko04966	Collecting duct acid secretion	15/1160	26/7206	1.53626940083e-06
ko04621	NOD-like receptor signaling pathway	6/1160	157/7206	1.61523578047e-06
ko04360	Axon guidance	66/1160	233/7206	1.77722898008e-06
ko05164	Influenza A	7/1160	167/7206	1.92075806187e-06
ko04022	cGMP-PKG signaling pathway	62/1160	216/7206	1.96659273571e-06
ko03013	RNA transport	7/1160	166/7206	2.84467315027e-06
ko05322	Systemic lupus erythematosus	6/1160	151/7206	4.99911283471e-06
ko04971	Gastric acid secretion	34/1160	98/7206	5.18108030673e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1160	74/7206	6.85196337263e-06
ko04740	Olfactory transduction	29/1160	80/7206	9.35331156485e-06
ko05030	Cocaine addiction	27/1160	73/7206	1.39612562219e-05
ko04010	MAPK signaling pathway	81/1160	321/7206	1.68147567403e-05
ko04924	Renin secretion	30/1160	86/7206	1.90862641567e-05
ko04610	Complement and coagulation cascades	1/1160	79/7206	2.07928810754e-05
ko04070	Phosphatidylinositol signaling system	36/1160	112/7206	2.21233335764e-05
ko04514	Cell adhesion molecules (CAMs)	40/1160	130/7206	2.92950057077e-05
ko04120	Ubiquitin mediated proteolysis	6/1160	138/7206	3.07502118079e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1160	79/7206	3.43004191078e-05
ko05169	Epstein-Barr virus infection	14/1160	206/7206	7.11605259315e-05
ko04064	NF-kappa B signaling pathway	3/1160	96/7206	0.00011247588264
ko04972	Pancreatic secretion	34/1160	111/7206	0.00011941478354
ko04745	Phototransduction - fly	16/1160	38/7206	0.000119517617586
ko05205	Proteoglycans in cancer	22/1160	271/7206	0.00013369048754
ko04110	Cell cycle	8/1160	145/7206	0.000139654136188
ko05161	Hepatitis B	11/1160	173/7206	0.000142863493344
ko04141	Protein processing in endoplasmic reticulum	12/1160	184/7206	0.000143417837107
ko04730	Long-term depression	26/1160	78/7206	0.000144885717238
ko04072	Phospholipase D signaling pathway	52/1160	197/7206	0.000169166693592
ko03008	Ribosome biogenesis in eukaryotes	2/1160	79/7206	0.000174580466719
ko04964	Proximal tubule bicarbonate reclamation	13/1160	29/7206	0.000245001565001
ko04260	Cardiac muscle contraction	30/1160	98/7206	0.0002679174636
ko05414	Dilated cardiomyopathy	33/1160	112/7206	0.000372481152494
ko05140	Leishmaniasis	2/1160	75/7206	0.000385620556984
ko04976	Bile secretion	25/1160	80/7206	0.000625808887821
ko05110	Vibrio cholerae infection	21/1160	63/7206	0.000754691324779
ko04626	Plant-pathogen interaction	9/1160	18/7206	0.000857661822203
ko04014	Ras signaling pathway	65/1160	279/7206	0.0015094869658
ko04612	Antigen processing and presentation	3/1160	77/7206	0.00153015061932
ko04540	Gap junction	34/1160	128/7206	0.00221880369202
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1160	100/7206	0.00230469594221
ko05162	Measles	8/1160	120/7206	0.00254975363892
ko05166	HTLV-I infection	29/1160	292/7206	0.00255811082848
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1160	14/7206	0.00331985275491
ko04915	Estrogen signaling pathway	34/1160	131/7206	0.00366592673831
ko03420	Nucleotide excision repair	1/1160	46/7206	0.00448757579271
ko04146	Peroxisome	5/1160	89/7206	0.00519332514321
ko04630	Jak-STAT signaling pathway	10/1160	132/7206	0.00560663090373
ko05321	Inflammatory bowel disease (IBD)	2/1160	56/7206	0.00575291295863
ko03022	Basal transcription factors	1/1160	44/7206	0.00670262783833
ko05144	Malaria	1/1160	45/7206	0.00684031488898
ko00071	Fatty acid degradation	1/1160	45/7206	0.00684031488898
ko04371	Apelin signaling pathway	42/1160	177/7206	0.00699219613227
ko04510	Focal adhesion	24/1160	240/7206	0.00726166693125
ko00562	Inositol phosphate metabolism	24/1160	89/7206	0.0083504494688
ko00240	Pyrimidine metabolism	8/1160	110/7206	0.00855077956339
ko00480	Glutathione metabolism	2/1160	55/7206	0.00862479260374
ko04640	Hematopoietic cell lineage	3/1160	64/7206	0.00941578478904
ko04214	Apoptosis - fly	4/1160	72/7206	0.00973072484898
ko00310	Lysine degradation	4/1160	73/7206	0.00973586847434
ko05145	Toxoplasmosis	10/1160	126/7206	0.00981420166414
ko04115	p53 signaling pathway	4/1160	74/7206	0.009935143602
ko04923	Regulation of lipolysis in adipocytes	21/1160	77/7206	0.0117476478529
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1160	59/7206	0.0119964870605
ko00590	Arachidonic acid metabolism	2/1160	52/7206	0.0123889318603
ko04750	Inflammatory mediator regulation of TRP channels	30/1160	122/7206	0.0129087632037
ko05222	Small cell lung cancer	6/1160	89/7206	0.012962210813
ko04210	Apoptosis	17/1160	180/7206	0.0132656790459
ko00330	Arginine and proline metabolism	3/1160	61/7206	0.0133304564637
ko04330	Notch signaling pathway	3/1160	62/7206	0.013648442443
ko04622	RIG-I-like receptor signaling pathway	3/1160	62/7206	0.013648442443
ko04922	Glucagon signaling pathway	31/1160	128/7206	0.015017912774
ko05206	MicroRNAs in cancer	17/1160	177/7206	0.0167678455409
ko04217	Necroptosis	17/1160	178/7206	0.0169718135759
ko00260	Glycine, serine and threonine metabolism	2/1160	48/7206	0.0177468943792
ko05219	Bladder cancer	2/1160	48/7206	0.0177468943792
ko04657	IL-17 signaling pathway	6/1160	87/7206	0.0178051633623
ko05133	Pertussis	6/1160	87/7206	0.0178051633623
ko05215	Prostate cancer	9/1160	111/7206	0.0186611807562
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1160	182/7206	0.0186713352601
ko04350	TGF-beta signaling pathway	8/1160	103/7206	0.0206863738533
ko04140	Autophagy - animal	16/1160	164/7206	0.0237334317848
ko03018	RNA degradation	6/1160	84/7206	0.0239915125187
ko05131	Shigellosis	6/1160	82/7206	0.0327674845355
ko00500	Starch and sucrose metabolism	1/1160	35/7206	0.0343582512862
ko04658	Th1 and Th2 cell differentiation	8/1160	96/7206	0.0356110088763
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1160	135/7206	0.0434822202809
ko04668	TNF signaling pathway	11/1160	120/7206	0.0438156543803
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1160	92/7206	0.0455382189177
ko05418	Fluid shear stress and atherosclerosis	18/1160	173/7206	0.0457816993432
ko03320	PPAR signaling pathway	5/1160	69/7206	0.0469522270916
ko04113	Meiosis - yeast	5/1160	70/7206	0.0477555654197
ko04722	Neurotrophin signaling pathway	35/1160	160/7206	0.0499175344155