ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1158	423/7206	9.80962884007e-56
ko04724	Glutamatergic synapse	86/1158	152/7206	7.80962394009e-31
ko05033	Nicotine addiction	46/1158	56/7206	9.57435171302e-28
ko04713	Circadian entrainment	74/1158	136/7206	3.38281538039e-25
ko04020	Calcium signaling pathway	108/1158	265/7206	8.59555830994e-23
ko05032	Morphine addiction	61/1158	110/7206	1.57526727331e-21
ko04727	GABAergic synapse	60/1158	110/7206	1.05673714376e-20
ko04024	cAMP signaling pathway	105/1158	279/7206	4.51551641598e-19
ko04725	Cholinergic synapse	73/1158	160/7206	5.23002084642e-19
ko04728	Dopaminergic synapse	80/1158	185/7206	5.77423927933e-19
ko04721	Synaptic vesicle cycle	45/1158	80/7206	1.61431688494e-16
ko04723	Retrograde endocannabinoid signaling	73/1158	175/7206	2.32946040949e-16
ko04921	Oxytocin signaling pathway	82/1158	209/7206	3.12635409331e-16
ko04911	Insulin secretion	55/1158	117/7206	2.61860984808e-15
ko05031	Amphetamine addiction	45/1158	91/7206	9.30571598662e-14
ko04726	Serotonergic synapse	57/1158	137/7206	5.60338883767e-13
ko04261	Adrenergic signaling in cardiomyocytes	74/1158	205/7206	1.25029539037e-12
ko04970	Salivary secretion	44/1158	95/7206	3.19031784957e-12
ko04022	cGMP-PKG signaling pathway	75/1158	216/7206	1.02702736122e-11
ko04720	Long-term potentiation	44/1158	99/7206	1.8184361746e-11
ko04742	Taste transduction	32/1158	61/7206	4.96006841334e-11
ko04744	Phototransduction	22/1158	36/7206	1.10385393681e-09
ko04925	Aldosterone synthesis and secretion	42/1158	105/7206	2.80450923378e-09
ko03040	Spliceosome	2/1158	145/7206	6.65890964283e-09
ko03010	Ribosome	1/1158	129/7206	6.85308904034e-09
ko05030	Cocaine addiction	32/1158	73/7206	1.59973349273e-08
ko05322	Systemic lupus erythematosus	4/1158	151/7206	1.35729088518e-07
ko04971	Gastric acid secretion	37/1158	98/7206	1.77734435838e-07
ko04740	Olfactory transduction	31/1158	80/7206	7.73530819673e-07
ko04070	Phosphatidylinositol signaling system	39/1158	112/7206	8.51763288229e-07
ko05168	Herpes simplex infection	8/1158	182/7206	1.08238940679e-06
ko04924	Renin secretion	32/1158	86/7206	1.7416587338e-06
ko04060	Cytokine-cytokine receptor interaction	9/1158	191/7206	1.80166333166e-06
ko03013	RNA transport	7/1158	166/7206	2.82453111902e-06
ko04072	Phospholipase D signaling pathway	57/1158	197/7206	4.33902702875e-06
ko04972	Pancreatic secretion	37/1158	111/7206	5.73296468286e-06
ko04730	Long-term depression	29/1158	78/7206	5.73442006292e-06
ko04745	Phototransduction - fly	18/1158	38/7206	5.99405162601e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1158	74/7206	6.74493981964e-06
ko05203	Viral carcinogenesis	20/1158	277/7206	1.20562075849e-05
ko04010	MAPK signaling pathway	80/1158	321/7206	3.29776467881e-05
ko04360	Axon guidance	62/1158	233/7206	3.72781897087e-05
ko04710	Circadian rhythm	18/1158	43/7206	4.85466082452e-05
ko04966	Collecting duct acid secretion	13/1158	26/7206	5.9215619073e-05
ko04371	Apelin signaling pathway	49/1158	177/7206	6.92582807262e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1158	79/7206	7.13593914267e-05
ko04540	Gap junction	38/1158	128/7206	8.49303899159e-05
ko05414	Dilated cardiomyopathy	34/1158	112/7206	0.000131680656597
ko04110	Cell cycle	8/1158	145/7206	0.000139933484361
ko04750	Inflammatory mediator regulation of TRP channels	36/1158	122/7206	0.000157115031899
ko05110	Vibrio cholerae infection	22/1158	63/7206	0.000205311084436
ko03008	Ribosome biogenesis in eukaryotes	2/1158	79/7206	0.000276229871539
ko04270	Vascular smooth muscle contraction	42/1158	154/7206	0.000338926542028
ko04915	Estrogen signaling pathway	36/1158	131/7206	0.00072009102155
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1158	100/7206	0.000908334070435
ko04120	Ubiquitin mediated proteolysis	9/1158	138/7206	0.000974961251439
ko00520	Amino sugar and nucleotide sugar metabolism	1/1158	55/7206	0.00132869615798
ko05169	Epstein-Barr virus infection	17/1158	206/7206	0.00137803989633
ko04514	Cell adhesion molecules (CAMs)	35/1158	130/7206	0.0015339113018
ko04976	Bile secretion	24/1158	80/7206	0.00180558830282
ko04260	Cardiac muscle contraction	28/1158	98/7206	0.00197176236954
ko04141	Protein processing in endoplasmic reticulum	15/1158	184/7206	0.00213509241416
ko04930	Type II diabetes mellitus	18/1158	54/7206	0.00218598603026
ko04922	Glucagon signaling pathway	34/1158	128/7206	0.00218872616379
ko04923	Regulation of lipolysis in adipocytes	23/1158	77/7206	0.00251616691739
ko04014	Ras signaling pathway	64/1158	279/7206	0.0026342816111
ko04350	TGF-beta signaling pathway	6/1158	103/7206	0.00264765326658
ko04330	Notch signaling pathway	2/1158	62/7206	0.00269224621024
ko04621	NOD-like receptor signaling pathway	12/1158	157/7206	0.00277494984457
ko04626	Plant-pathogen interaction	8/1158	18/7206	0.00418714123367
ko04960	Aldosterone-regulated sodium reabsorption	14/1158	41/7206	0.00420374401967
ko04973	Carbohydrate digestion and absorption	14/1158	42/7206	0.0050618606631
ko05164	Influenza A	14/1158	167/7206	0.00526060084854
ko05166	HTLV-I infection	30/1158	292/7206	0.00549520042218
ko05321	Inflammatory bowel disease (IBD)	2/1158	56/7206	0.00576436961149
ko05144	Malaria	1/1158	45/7206	0.00682998024166
ko05140	Leishmaniasis	4/1158	75/7206	0.00692220032877
ko04612	Antigen processing and presentation	4/1158	77/7206	0.00713029654338
ko04064	NF-kappa B signaling pathway	6/1158	96/7206	0.00714649176254
ko03420	Nucleotide excision repair	1/1158	46/7206	0.00719329106706
ko05162	Measles	9/1158	120/7206	0.00802955674169
ko00562	Inositol phosphate metabolism	24/1158	89/7206	0.00826834592531
ko04912	GnRH signaling pathway	31/1158	122/7206	0.00841629867231
ko00240	Pyrimidine metabolism	8/1158	110/7206	0.00855557234986
ko05231	Choline metabolism in cancer	33/1158	134/7206	0.00885745514892
ko04711	Circadian rhythm - fly	6/1158	13/7206	0.0105270402213
ko05161	Hepatitis B	16/1158	173/7206	0.0116247917848
ko04630	Jak-STAT signaling pathway	11/1158	132/7206	0.0117843926137
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1158	59/7206	0.0118705360252
ko00590	Arachidonic acid metabolism	2/1158	52/7206	0.0123738762186
ko01212	Fatty acid metabolism	3/1158	60/7206	0.0133344335163
ko04610	Complement and coagulation cascades	5/1158	79/7206	0.0134391942033
ko05205	Proteoglycans in cancer	29/1158	271/7206	0.014173364967
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1158	14/7206	0.0159576231975
ko04657	IL-17 signaling pathway	6/1158	87/7206	0.0177749984249
ko05219	Bladder cancer	2/1158	48/7206	0.0177782129088
ko04964	Proximal tubule bicarbonate reclamation	10/1158	29/7206	0.0179960892637
ko05016	Huntington's disease	22/1158	215/7206	0.0180068365222
ko05217	Basal cell carcinoma	4/1158	68/7206	0.0190889446847
ko04015	Rap1 signaling pathway	59/1158	278/7206	0.0196435671724
ko05230	Central carbon metabolism in cancer	21/1158	81/7206	0.0214585252575
ko05200	Pathways in cancer	61/1158	492/7206	0.0218970160818
ko04071	Sphingolipid signaling pathway	37/1158	162/7206	0.0225927331127
ko03410	Base excision repair	1/1158	38/7206	0.0235176067313
ko04550	Signaling pathways regulating pluripotency of stem cells	16/1158	165/7206	0.0238203409605
ko03018	RNA degradation	6/1158	84/7206	0.023966591139
ko04213	Longevity regulating pathway - multiple species	22/1158	86/7206	0.0252209225655
ko00480	Glutathione metabolism	3/1158	55/7206	0.0266742780908
ko04916	Melanogenesis	33/1158	142/7206	0.0274262388074
ko05214	Glioma	20/1158	79/7206	0.0305043632809
ko00860	Porphyrin and chlorophyll metabolism	1/1158	34/7206	0.0334211722992
ko04214	Apoptosis - fly	5/1158	72/7206	0.0347065279467
ko04658	Th1 and Th2 cell differentiation	8/1158	96/7206	0.0356360159672
ko04622	RIG-I-like receptor signaling pathway	4/1158	62/7206	0.0364612616826
ko00010	Glycolysis / Gluconeogenesis	19/1158	74/7206	0.0365938702842
ko00280	Valine, leucine and isoleucine degradation	3/1158	54/7206	0.038342554308
ko04918	Thyroid hormone synthesis	21/1158	86/7206	0.0387916438654
ko05133	Pertussis	7/1158	87/7206	0.0393087656069
ko04510	Focal adhesion	27/1158	240/7206	0.0394901842805
ko04146	Peroxisome	7/1158	89/7206	0.0403544291609
ko04114	Oocyte meiosis	31/1158	139/7206	0.0474942967319
ko04962	Vasopressin-regulated water reabsorption	15/1158	58/7206	0.0481759951155
ko05206	MicroRNAs in cancer	19/1158	177/7206	0.049153249987
ko04217	Necroptosis	19/1158	178/7206	0.0491815488791