ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 54/594 191/7206 1.15433081095e-16 ko04380 Osteoclast differentiation 38/594 134/7206 4.21664562945e-12 ko05340 Primary immunodeficiency 16/594 30/7206 1.82391602314e-10 ko05164 Influenza A 40/594 167/7206 3.52061483438e-10 ko04650 Natural killer cell mediated cytotoxicity 29/594 97/7206 3.90523927909e-10 ko04621 NOD-like receptor signaling pathway 38/594 157/7206 7.14628640727e-10 ko05321 Inflammatory bowel disease (IBD) 21/594 56/7206 1.05231864767e-09 ko05140 Leishmaniasis 23/594 75/7206 1.53228964738e-08 ko04217 Necroptosis 38/594 178/7206 2.97846336e-08 ko04064 NF-kappa B signaling pathway 26/594 96/7206 3.16351986572e-08 ko05145 Toxoplasmosis 30/594 126/7206 6.87541196964e-08 ko04659 Th17 cell differentiation 27/594 106/7206 7.0277470652e-08 ko05330 Allograft rejection 12/594 24/7206 9.48243173348e-08 ko05162 Measles 28/594 120/7206 2.97011888502e-07 ko04620 Toll-like receptor signaling pathway 25/594 100/7206 3.18026523712e-07 ko04640 Hematopoietic cell lineage 19/594 64/7206 4.88519163312e-07 ko04660 T cell receptor signaling pathway 28/594 124/7206 6.10993882212e-07 ko04610 Complement and coagulation cascades 21/594 79/7206 9.47885078812e-07 ko05320 Autoimmune thyroid disease 12/594 29/7206 1.23718885271e-06 ko04658 Th1 and Th2 cell differentiation 23/594 96/7206 2.10324508408e-06 ko05150 Staphylococcus aureus infection 13/594 36/7206 2.78152224686e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 36/594 191/7206 2.81487182621e-06 ko04672 Intestinal immune network for IgA production 13/594 37/7206 3.96904231065e-06 ko05332 Graft-versus-host disease 9/594 18/7206 4.08589983596e-06 ko05152 Tuberculosis 34/594 187/7206 9.20110455104e-06 ko04612 Antigen processing and presentation 19/594 77/7206 1.02472390432e-05 ko05168 Herpes simplex infection 33/594 182/7206 1.34072738405e-05 ko03013 RNA transport 1/594 166/7206 1.97070904224e-05 ko04062 Chemokine signaling pathway 35/594 201/7206 1.97405607498e-05 ko04662 B cell receptor signaling pathway 20/594 88/7206 2.24544237159e-05 ko05310 Asthma 8/594 17/7206 2.52998348072e-05 ko04668 TNF signaling pathway 24/594 120/7206 3.4338642663e-05 ko05133 Pertussis 19/594 87/7206 6.44071235579e-05 ko03040 Spliceosome 1/594 145/7206 9.10398365149e-05 ko00120 Primary bile acid biosynthesis 8/594 20/7206 0.000104871013762 ko05161 Hepatitis B 30/594 173/7206 0.000107340018892 ko04622 RIG-I-like receptor signaling pathway 15/594 62/7206 0.000111221766052 ko04390 Hippo signaling pathway 3/594 188/7206 0.000133288458496 ko05160 Hepatitis C 27/594 153/7206 0.000137686840849 ko00590 Arachidonic acid metabolism 13/594 52/7206 0.000222687162133 ko05323 Rheumatoid arthritis 18/594 89/7206 0.000279367588059 ko03010 Ribosome 1/594 129/7206 0.000290189036741 ko04137 Mitophagy - animal 17/594 82/7206 0.000301138693893 ko04630 Jak-STAT signaling pathway 23/594 132/7206 0.000568926895295 ko04940 Type I diabetes mellitus 9/594 32/7206 0.000824303093061 ko05144 Malaria 11/594 45/7206 0.000825363862709 ko05142 Chagas disease (American trypanosomiasis) 22/594 130/7206 0.0010211597458 ko04623 Cytosolic DNA-sensing pathway 10/594 41/7206 0.00143987100889 ko04670 Leukocyte transendothelial migration 24/594 151/7206 0.00149155303348 ko04145 Phagosome 25/594 162/7206 0.00206287200582 ko04611 Platelet activation 25/594 163/7206 0.0021726078433 ko04210 Apoptosis 27/594 180/7206 0.00219473854034 ko04666 Fc gamma R-mediated phagocytosis 20/594 122/7206 0.00246702773297 ko00592 alpha-Linolenic acid metabolism 6/594 19/7206 0.00326681384166 ko04068 FoxO signaling pathway 25/594 167/7206 0.00382960099158 ko04664 Fc epsilon RI signaling pathway 14/594 77/7206 0.00498658276016 ko03015 mRNA surveillance pathway 1/594 93/7206 0.00655695774151 ko04072 Phospholipase D signaling pathway 27/594 197/7206 0.00805965058425 ko04933 AGE-RAGE signaling pathway in diabetic complications 20/594 135/7206 0.0102492096058 ko05418 Fluid shear stress and atherosclerosis 24/594 173/7206 0.0109500877467 ko04310 Wnt signaling pathway 6/594 181/7206 0.0127950036297 ko04110 Cell cycle 4/594 145/7206 0.0133760760956 ko04514 Cell adhesion molecules (CAMs) 19/594 130/7206 0.0142704343803 ko04657 IL-17 signaling pathway 14/594 87/7206 0.0159270050308 ko05224 Breast cancer 6/594 174/7206 0.0168450814004 ko05134 Legionellosis 12/594 74/7206 0.018700609924 ko00051 Fructose and mannose metabolism 8/594 42/7206 0.0195742468868 ko05034 Alcoholism 10/594 238/7206 0.0218034743975 ko05131 Shigellosis 13/594 82/7206 0.0229559769557 ko05146 Amoebiasis 15/594 99/7206 0.0244748080596 ko00982 Drug metabolism - cytochrome P450 7/594 37/7206 0.0291836349475 ko01200 Carbon metabolism 4/594 128/7206 0.0332534675033 ko04070 Phosphatidylinositol signaling system 16/594 112/7206 0.0349688537727 ko05231 Choline metabolism in cancer 18/594 134/7206 0.0374389770935 ko05132 Salmonella infection 14/594 98/7206 0.039415870369 ko05230 Central carbon metabolism in cancer 12/594 81/7206 0.0401263240468 ko00980 Metabolism of xenobiotics by cytochrome P450 7/594 40/7206 0.042743017992 ko00950 Isoquinoline alkaloid biosynthesis 3/594 10/7206 0.0431492994609 ko00360 Phenylalanine metabolism 4/594 17/7206 0.0458435840114 ko00350 Tyrosine metabolism 6/594 33/7206 0.0499788136416