ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	212/1293	423/7206	3.98937725413e-55
ko04724	Glutamatergic synapse	92/1293	152/7206	3.13237246866e-32
ko05033	Nicotine addiction	50/1293	56/7206	2.38414785194e-31
ko05032	Morphine addiction	71/1293	110/7206	1.41022752044e-27
ko04713	Circadian entrainment	80/1293	136/7206	6.10485294673e-27
ko04727	GABAergic synapse	69/1293	110/7206	9.95330090505e-26
ko04728	Dopaminergic synapse	89/1293	185/7206	1.63137100872e-21
ko04721	Synaptic vesicle cycle	52/1293	80/7206	1.05924991186e-20
ko04020	Calcium signaling pathway	107/1293	265/7206	2.38543045831e-18
ko04725	Cholinergic synapse	76/1293	160/7206	4.07221191222e-18
ko04723	Retrograde endocannabinoid signaling	80/1293	175/7206	9.27922503863e-18
ko04024	cAMP signaling pathway	109/1293	279/7206	2.14263963969e-17
ko04911	Insulin secretion	61/1293	117/7206	3.04708982869e-17
ko04742	Taste transduction	39/1293	61/7206	1.79344230054e-15
ko04726	Serotonergic synapse	63/1293	137/7206	2.20098691141e-14
ko04744	Phototransduction	27/1293	36/7206	1.00828772756e-13
ko04921	Oxytocin signaling pathway	82/1293	209/7206	1.75026288065e-13
ko03040	Spliceosome	1/1293	145/7206	1.56236794498e-11
ko05031	Amphetamine addiction	44/1293	91/7206	2.41790534686e-11
ko04970	Salivary secretion	45/1293	95/7206	3.47477884904e-11
ko04740	Olfactory transduction	40/1293	80/7206	5.26158268575e-11
ko04261	Adrenergic signaling in cardiomyocytes	75/1293	205/7206	1.18741048487e-10
ko04720	Long-term potentiation	45/1293	99/7206	1.95734730754e-10
ko05203	Viral carcinogenesis	15/1293	277/7206	6.63004565714e-10
ko04022	cGMP-PKG signaling pathway	73/1293	216/7206	1.30465593255e-08
ko04925	Aldosterone synthesis and secretion	43/1293	105/7206	2.50807662315e-08
ko04971	Gastric acid secretion	41/1293	98/7206	2.81162332478e-08
ko04060	Cytokine-cytokine receptor interaction	9/1293	191/7206	5.2071957481e-08
ko05030	Cocaine addiction	33/1293	73/7206	6.16363980104e-08
ko03013	RNA transport	7/1293	166/7206	1.69226049868e-07
ko04360	Axon guidance	74/1293	233/7206	2.06499465886e-07
ko05322	Systemic lupus erythematosus	6/1293	151/7206	2.78590556253e-07
ko05164	Influenza A	8/1293	167/7206	5.99133905888e-07
ko05168	Herpes simplex infection	10/1293	182/7206	1.08369417762e-06
ko04972	Pancreatic secretion	41/1293	111/7206	2.06055947845e-06
ko04621	NOD-like receptor signaling pathway	8/1293	157/7206	2.53642164288e-06
ko04976	Bile secretion	32/1293	80/7206	2.8880574608e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1293	74/7206	4.4795636375e-06
ko04966	Collecting duct acid secretion	15/1293	26/7206	6.31164064378e-06
ko04070	Phosphatidylinositol signaling system	40/1293	112/7206	8.51396735134e-06
ko04141	Protein processing in endoplasmic reticulum	12/1293	184/7206	9.13450547784e-06
ko04120	Ubiquitin mediated proteolysis	7/1293	138/7206	9.53879603364e-06
ko05169	Epstein-Barr virus infection	15/1293	206/7206	1.23116269442e-05
ko04110	Cell cycle	8/1293	145/7206	1.50604772689e-05
ko05205	Proteoglycans in cancer	24/1293	271/7206	2.4038558673e-05
ko04514	Cell adhesion molecules (CAMs)	43/1293	130/7206	2.52803327321e-05
ko04540	Gap junction	42/1293	128/7206	3.81804413857e-05
ko05110	Vibrio cholerae infection	25/1293	63/7206	4.31228968624e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1293	79/7206	4.43994414999e-05
ko04924	Renin secretion	31/1293	86/7206	5.32060774471e-05
ko04010	MAPK signaling pathway	86/1293	321/7206	5.41519931322e-05
ko04750	Inflammatory mediator regulation of TRP channels	40/1293	122/7206	6.60662746445e-05
ko04064	NF-kappa B signaling pathway	4/1293	96/7206	7.93262954177e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1293	79/7206	7.98552854191e-05
ko05140	Leishmaniasis	2/1293	75/7206	0.000102493932819
ko05161	Hepatitis B	13/1293	173/7206	0.000117760095092
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1293	59/7206	0.000118426099802
ko04745	Phototransduction - fly	17/1293	38/7206	0.000118867708463
ko05162	Measles	7/1293	120/7206	0.000162345520846
ko05414	Dilated cardiomyopathy	36/1293	112/7206	0.000257230543073
ko04612	Antigen processing and presentation	3/1293	77/7206	0.000449394411031
ko04260	Cardiac muscle contraction	32/1293	98/7206	0.000452685792253
ko04072	Phospholipase D signaling pathway	55/1293	197/7206	0.000453602928013
ko04730	Long-term depression	27/1293	78/7206	0.000481978518499
ko05166	HTLV-I infection	31/1293	292/7206	0.000578226526481
ko04964	Proximal tubule bicarbonate reclamation	13/1293	29/7206	0.000734835678602
ko04630	Jak-STAT signaling pathway	10/1293	132/7206	0.000838266673346
ko04146	Peroxisome	5/1293	89/7206	0.00117647756653
ko04371	Apelin signaling pathway	49/1293	177/7206	0.00137990672282
ko05215	Prostate cancer	8/1293	111/7206	0.00167432237923
ko04657	IL-17 signaling pathway	5/1293	87/7206	0.00168996408435
ko03420	Nucleotide excision repair	1/1293	46/7206	0.0017820822519
ko05145	Toxoplasmosis	10/1293	126/7206	0.00211770647874
ko04710	Circadian rhythm	16/1293	43/7206	0.00233278441489
ko04014	Ras signaling pathway	70/1293	279/7206	0.00239827926628
ko00520	Amino sugar and nucleotide sugar metabolism	2/1293	55/7206	0.0024184093263
ko00480	Glutathione metabolism	2/1293	55/7206	0.0024184093263
ko05321	Inflammatory bowel disease (IBD)	2/1293	56/7206	0.002443987727
ko03022	Basal transcription factors	1/1293	44/7206	0.00268850697869
ko05144	Malaria	1/1293	45/7206	0.00273517318666
ko00071	Fatty acid degradation	1/1293	45/7206	0.00273517318666
ko05131	Shigellosis	5/1293	82/7206	0.00333969777552
ko00330	Arginine and proline metabolism	3/1293	61/7206	0.00415837086398
ko04622	RIG-I-like receptor signaling pathway	3/1293	62/7206	0.00416523496414
ko04923	Regulation of lipolysis in adipocytes	24/1293	77/7206	0.00420288382681
ko04658	Th1 and Th2 cell differentiation	7/1293	96/7206	0.00451066747121
ko05133	Pertussis	6/1293	87/7206	0.00458920373978
ko04610	Complement and coagulation cascades	5/1293	79/7206	0.00462372864785
ko00562	Inositol phosphate metabolism	27/1293	89/7206	0.00485891923468
ko04217	Necroptosis	18/1293	178/7206	0.0053378389278
ko00240	Pyrimidine metabolism	9/1293	110/7206	0.00550402923289
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1293	100/7206	0.00564940917122
ko04915	Estrogen signaling pathway	36/1293	131/7206	0.00573512027647
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1293	182/7206	0.00600039869849
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1293	14/7206	0.0062430726167
ko03018	RNA degradation	6/1293	84/7206	0.00635039797042
ko05219	Bladder cancer	2/1293	48/7206	0.00773114339571
ko04620	Toll-like receptor signaling pathway	8/1293	100/7206	0.00805180703071
ko04626	Plant-pathogen interaction	8/1293	18/7206	0.0083771391303
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1293	135/7206	0.00896812693447
ko00310	Lysine degradation	5/1293	73/7206	0.00900247302576
ko04115	p53 signaling pathway	5/1293	74/7206	0.009006199266
ko00630	Glyoxylate and dicarboxylate metabolism	1/1293	38/7206	0.00941099278497
ko03410	Base excision repair	1/1293	38/7206	0.00941099278497
ko00280	Valine, leucine and isoleucine degradation	3/1293	54/7206	0.0123497745573
ko04210	Apoptosis	20/1293	180/7206	0.0137484860649
ko04922	Glucagon signaling pathway	34/1293	128/7206	0.0142033475786
ko04974	Protein digestion and absorption	27/1293	96/7206	0.0150016514705
ko05220	Chronic myeloid leukemia	7/1293	85/7206	0.0154145256566
ko05418	Fluid shear stress and atherosclerosis	19/1293	173/7206	0.0156385374197
ko04510	Focal adhesion	29/1293	240/7206	0.01627160347
ko04218	Cellular senescence	20/1293	177/7206	0.0172694182506
ko04140	Autophagy - animal	18/1293	164/7206	0.0175628069933
ko00590	Arachidonic acid metabolism	3/1293	52/7206	0.0176245197112
ko04711	Circadian rhythm - fly	6/1293	13/7206	0.0179714231667
ko04330	Notch signaling pathway	4/1293	62/7206	0.0183706129689
ko04930	Type II diabetes mellitus	17/1293	54/7206	0.0187126761974
ko04270	Vascular smooth muscle contraction	39/1293	154/7206	0.0193146044447
ko00965	Betalain biosynthesis	3/1293	4/7206	0.0199665575302
ko05212	Pancreatic cancer	7/1293	83/7206	0.0207875731106
ko04978	Mineral absorption	13/1293	40/7206	0.0223712932449
ko04918	Thyroid hormone synthesis	24/1293	86/7206	0.0225821485234
ko01524	Platinum drug resistance	6/1293	76/7206	0.0228466107061
ko04912	GnRH signaling pathway	32/1293	122/7206	0.0229426733319
ko05132	Salmonella infection	9/1293	98/7206	0.0233165706669
ko05016	Huntington's disease	26/1293	215/7206	0.0237042346636
ko05222	Small cell lung cancer	8/1293	89/7206	0.0254897374284
ko04350	TGF-beta signaling pathway	10/1293	103/7206	0.0273409583272
ko04214	Apoptosis - fly	6/1293	72/7206	0.0303195395069
ko04142	Lysosome	17/1293	151/7206	0.0315106464218
ko04640	Hematopoietic cell lineage	5/1293	64/7206	0.0326268357356
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1293	40/7206	0.0358994066148
ko05206	MicroRNAs in cancer	21/1293	177/7206	0.0366181532401
ko04659	Th17 cell differentiation	11/1293	106/7206	0.0409373879845
ko04113	Meiosis - yeast	6/1293	70/7206	0.0409634193359
ko04668	TNF signaling pathway	13/1293	120/7206	0.0410294488314
ko05320	Autoimmune thyroid disease	1/1293	29/7206	0.0483195242567