ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	170/1152	423/7206	2.90036908424e-35
ko04724	Glutamatergic synapse	79/1152	152/7206	3.05973815907e-25
ko05033	Nicotine addiction	40/1152	56/7206	2.39129563498e-20
ko04713	Circadian entrainment	67/1152	136/7206	6.68876274384e-20
ko04727	GABAergic synapse	57/1152	110/7206	1.98497458299e-18
ko05032	Morphine addiction	57/1152	110/7206	1.98497458299e-18
ko04721	Synaptic vesicle cycle	46/1152	80/7206	1.82613582407e-17
ko04725	Cholinergic synapse	67/1152	160/7206	2.51971867537e-15
ko04728	Dopaminergic synapse	73/1152	185/7206	6.06216222589e-15
ko04723	Retrograde endocannabinoid signaling	70/1152	175/7206	9.87764915964e-15
ko04020	Calcium signaling pathway	91/1152	265/7206	6.99853716237e-14
ko04726	Serotonergic synapse	57/1152	137/7206	4.47073274481e-13
ko04742	Taste transduction	32/1152	61/7206	4.30823393794e-11
ko04024	cAMP signaling pathway	88/1152	279/7206	5.32804497712e-11
ko04744	Phototransduction	23/1152	36/7206	1.11914437582e-10
ko04970	Salivary secretion	41/1152	95/7206	2.32323972747e-10
ko04921	Oxytocin signaling pathway	70/1152	209/7206	2.80814986241e-10
ko04911	Insulin secretion	46/1152	117/7206	8.07136418727e-10
ko05322	Systemic lupus erythematosus	2/1152	151/7206	2.96507832748e-09
ko03010	Ribosome	1/1152	129/7206	6.68764142684e-09
ko05031	Amphetamine addiction	37/1152	91/7206	1.27254686723e-08
ko04925	Aldosterone synthesis and secretion	40/1152	105/7206	3.94250890169e-08
ko03040	Spliceosome	3/1152	145/7206	6.03048475171e-08
ko04971	Gastric acid secretion	36/1152	98/7206	4.52134548699e-07
ko03013	RNA transport	6/1152	166/7206	5.34444956871e-07
ko04720	Long-term potentiation	36/1152	99/7206	5.86350838309e-07
ko04972	Pancreatic secretion	39/1152	111/7206	6.08282755443e-07
ko05203	Viral carcinogenesis	17/1152	277/7206	6.17124263238e-07
ko04966	Collecting duct acid secretion	15/1152	26/7206	1.4025417567e-06
ko05168	Herpes simplex infection	9/1152	182/7206	4.98028535672e-06
ko04261	Adrenergic signaling in cardiomyocytes	58/1152	205/7206	6.48099782663e-06
ko04022	cGMP-PKG signaling pathway	60/1152	216/7206	7.53816768983e-06
ko04110	Cell cycle	6/1152	145/7206	1.02483081131e-05
ko04060	Cytokine-cytokine receptor interaction	11/1152	191/7206	2.10880387707e-05
ko05162	Measles	4/1152	120/7206	2.23372672993e-05
ko04745	Phototransduction - fly	17/1152	38/7206	2.59809938601e-05
ko04740	Olfactory transduction	28/1152	80/7206	3.62862843478e-05
ko05164	Influenza A	9/1152	167/7206	3.87968819426e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1152	29/7206	4.76385216446e-05
ko00120	Primary bile acid biosynthesis	11/1152	20/7206	6.8877764952e-05
ko04270	Vascular smooth muscle contraction	44/1152	154/7206	7.81750039917e-05
ko04070	Phosphatidylinositol signaling system	34/1152	112/7206	0.000123832460827
ko04730	Long-term depression	26/1152	78/7206	0.000132427711071
ko04924	Renin secretion	28/1152	86/7206	0.000143903122941
ko05169	Epstein-Barr virus infection	15/1152	206/7206	0.000225165166143
ko03008	Ribosome biogenesis in eukaryotes	2/1152	79/7206	0.000271346156418
ko04976	Bile secretion	26/1152	80/7206	0.000290977678278
ko05030	Cocaine addiction	24/1152	73/7206	0.000304021923506
ko05014	Amyotrophic lateral sclerosis (ALS)	24/1152	74/7206	0.000365719457544
ko04621	NOD-like receptor signaling pathway	10/1152	157/7206	0.000376225448333
ko04120	Ubiquitin mediated proteolysis	8/1152	138/7206	0.000379308000482
ko04750	Inflammatory mediator regulation of TRP channels	35/1152	122/7206	0.000394155644367
ko05166	HTLV-I infection	26/1152	292/7206	0.000428799359382
ko05110	Vibrio cholerae infection	21/1152	63/7206	0.000719767675408
ko04626	Plant-pathogen interaction	9/1152	18/7206	0.000814069623884
ko04540	Gap junction	35/1152	128/7206	0.000912157248452
ko04141	Protein processing in endoplasmic reticulum	14/1152	184/7206	0.00101678888006
ko05161	Hepatitis B	13/1152	173/7206	0.00108617504271
ko05205	Proteoglycans in cancer	25/1152	271/7206	0.00127558873437
ko00520	Amino sugar and nucleotide sugar metabolism	1/1152	55/7206	0.00132693197139
ko04072	Phospholipase D signaling pathway	48/1152	197/7206	0.00209975422336
ko04371	Apelin signaling pathway	44/1152	177/7206	0.00240117152943
ko04710	Circadian rhythm	15/1152	43/7206	0.00241544028528
ko04514	Cell adhesion molecules (CAMs)	34/1152	130/7206	0.00242964339102
ko04630	Jak-STAT signaling pathway	9/1152	132/7206	0.0024861484235
ko04550	Signaling pathways regulating pluripotency of stem cells	13/1152	165/7206	0.0025270133302
ko04330	Notch signaling pathway	2/1152	62/7206	0.0026962293943
ko04974	Protein digestion and absorption	27/1152	96/7206	0.00280272748098
ko05200	Pathways in cancer	56/1152	492/7206	0.00331660070923
ko04014	Ras signaling pathway	63/1152	279/7206	0.00341115911181
ko04217	Necroptosis	15/1152	178/7206	0.00363594651193
ko04960	Aldosterone-regulated sodium reabsorption	14/1152	41/7206	0.00406865320086
ko05219	Bladder cancer	1/1152	48/7206	0.00460774903308
ko04010	MAPK signaling pathway	70/1152	321/7206	0.00493218043768
ko05016	Huntington's disease	20/1152	215/7206	0.0058908039328
ko03420	Nucleotide excision repair	1/1152	46/7206	0.00711233801168
ko05416	Viral myocarditis	2/1152	55/7206	0.00855821131071
ko04510	Focal adhesion	24/1152	240/7206	0.00913307180556
ko04350	TGF-beta signaling pathway	7/1152	103/7206	0.00933576370818
ko05140	Leishmaniasis	4/1152	75/7206	0.0101499516005
ko04711	Circadian rhythm - fly	6/1152	13/7206	0.0102611294043
ko04915	Estrogen signaling pathway	32/1152	131/7206	0.011118794878
ko04810	Regulation of actin cytoskeleton	28/1152	264/7206	0.0130482716665
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1152	182/7206	0.0134484183769
ko04622	RIG-I-like receptor signaling pathway	3/1152	62/7206	0.0135355821298
ko04113	Meiosis - yeast	4/1152	70/7206	0.0136634270614
ko00350	Tyrosine metabolism	11/1152	33/7206	0.0138916354103
ko04214	Apoptosis - fly	4/1152	72/7206	0.0140376310954
ko00643	Styrene degradation	3/1152	4/7206	0.0143563866999
ko04922	Glucagon signaling pathway	31/1152	128/7206	0.0144365149033
ko05211	Renal cell carcinoma	7/1152	96/7206	0.0165833483347
ko00830	Retinol metabolism	13/1152	42/7206	0.0172702781064
ko04657	IL-17 signaling pathway	6/1152	87/7206	0.0177185090009
ko05217	Basal cell carcinoma	4/1152	68/7206	0.0190715569775
ko00910	Nitrogen metabolism	7/1152	19/7206	0.0225662030481
ko03410	Base excision repair	1/1152	38/7206	0.0233511763706
ko05212	Pancreatic cancer	6/1152	83/7206	0.0239353291129
ko04930	Type II diabetes mellitus	15/1152	54/7206	0.0243242488678
ko04115	p53 signaling pathway	5/1152	74/7206	0.0253781952359
ko05145	Toxoplasmosis	11/1152	126/7206	0.026368605215
ko04978	Mineral absorption	12/1152	40/7206	0.0270216894392
ko04620	Toll-like receptor signaling pathway	8/1152	100/7206	0.0271646992092
ko05131	Shigellosis	6/1152	82/7206	0.0325181316377
ko04658	Th1 and Th2 cell differentiation	8/1152	96/7206	0.0357718015337
ko00010	Glycolysis / Gluconeogenesis	19/1152	74/7206	0.0361678552012
ko05133	Pertussis	7/1152	87/7206	0.0394047666414
ko05222	Small cell lung cancer	7/1152	89/7206	0.0400510359134
ko04923	Regulation of lipolysis in adipocytes	19/1152	77/7206	0.0420920115429
ko04610	Complement and coagulation cascades	6/1152	79/7206	0.0434435242405
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1152	92/7206	0.0442645567542
ko05224	Breast cancer	18/1152	174/7206	0.0458015199223
ko02010	ABC transporters	11/1152	39/7206	0.0469116566851
ko05215	Prostate cancer	10/1152	111/7206	0.0490186012215
ko04210	Apoptosis	19/1152	180/7206	0.0495853245469