ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	79/904	152/7206	1.23293947073e-32
ko04080	Neuroactive ligand-receptor interaction	142/904	423/7206	1.75916372457e-31
ko05033	Nicotine addiction	44/904	56/7206	1.05640019329e-29
ko05032	Morphine addiction	62/904	110/7206	2.10069677839e-28
ko04727	GABAergic synapse	60/904	110/7206	1.79838880052e-26
ko04713	Circadian entrainment	64/904	136/7206	1.74393021865e-23
ko04723	Retrograde endocannabinoid signaling	71/904	175/7206	2.92835543358e-21
ko04728	Dopaminergic synapse	73/904	185/7206	5.51847575071e-21
ko04725	Cholinergic synapse	64/904	160/7206	7.04517576237e-19
ko04744	Phototransduction	26/904	36/7206	1.92088719996e-16
ko04721	Synaptic vesicle cycle	39/904	80/7206	2.05808099764e-15
ko04024	cAMP signaling pathway	84/904	279/7206	2.86164294311e-15
ko04911	Insulin secretion	46/904	117/7206	1.44139948405e-13
ko04020	Calcium signaling pathway	76/904	265/7206	8.48764748582e-13
ko04921	Oxytocin signaling pathway	65/904	209/7206	1.06100346363e-12
ko04726	Serotonergic synapse	48/904	137/7206	6.30723515526e-12
ko04261	Adrenergic signaling in cardiomyocytes	62/904	205/7206	9.22920556881e-12
ko04742	Taste transduction	29/904	61/7206	1.90563088329e-11
ko05031	Amphetamine addiction	35/904	91/7206	2.55671929753e-10
ko04720	Long-term potentiation	34/904	99/7206	1.42086451e-08
ko05030	Cocaine addiction	27/904	73/7206	7.62692905194e-08
ko03040	Spliceosome	1/904	145/7206	1.49242969385e-07
ko04970	Salivary secretion	31/904	95/7206	2.32917491621e-07
ko04925	Aldosterone synthesis and secretion	32/904	105/7206	8.51209518535e-07
ko04072	Phospholipase D signaling pathway	48/904	197/7206	3.39263312161e-06
ko05203	Viral carcinogenesis	12/904	277/7206	4.35581252533e-06
ko03013	RNA transport	4/904	166/7206	4.53509592032e-06
ko04022	cGMP-PKG signaling pathway	51/904	216/7206	5.16556763583e-06
ko04740	Olfactory transduction	25/904	80/7206	8.18281976652e-06
ko04070	Phosphatidylinositol signaling system	31/904	112/7206	1.62687026957e-05
ko04010	MAPK signaling pathway	67/904	321/7206	1.9831303128e-05
ko05322	Systemic lupus erythematosus	4/904	151/7206	2.94279096732e-05
ko04060	Cytokine-cytokine receptor interaction	7/904	191/7206	3.25261706063e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	22/904	74/7206	6.64982192515e-05
ko04971	Gastric acid secretion	27/904	98/7206	7.356818453e-05
ko04730	Long-term depression	23/904	78/7206	7.97760082113e-05
ko04745	Phototransduction - fly	14/904	38/7206	0.000113385049698
ko04972	Pancreatic secretion	29/904	111/7206	0.000115963274118
ko04514	Cell adhesion molecules (CAMs)	32/904	130/7206	0.000136489490097
ko04260	Cardiac muscle contraction	26/904	98/7206	0.000153710086982
ko05164	Influenza A	7/904	167/7206	0.000336972560015
ko04610	Complement and coagulation cascades	1/904	79/7206	0.000488342119014
ko04915	Estrogen signaling pathway	30/904	131/7206	0.000786913156548
ko04360	Axon guidance	47/904	233/7206	0.000822550561749
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	21/904	79/7206	0.000830324934203
ko04621	NOD-like receptor signaling pathway	7/904	157/7206	0.000890251332307
ko05168	Herpes simplex infection	9/904	182/7206	0.000894721420639
ko05205	Proteoglycans in cancer	17/904	271/7206	0.000980985122356
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/904	59/7206	0.0010123862609
ko04014	Ras signaling pathway	53/904	279/7206	0.00163236101514
ko04120	Ubiquitin mediated proteolysis	6/904	138/7206	0.00165860189938
ko04710	Circadian rhythm	13/904	43/7206	0.00171517915706
ko04141	Protein processing in endoplasmic reticulum	10/904	184/7206	0.00211995468007
ko04924	Renin secretion	21/904	86/7206	0.00258104146712
ko04711	Circadian rhythm - fly	6/904	13/7206	0.00300624082148
ko04110	Cell cycle	7/904	145/7206	0.00321178537459
ko05414	Dilated cardiomyopathy	25/904	112/7206	0.00357068126272
ko05140	Leishmaniasis	2/904	75/7206	0.00466482925001
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/904	14/7206	0.00470853002808
ko04612	Antigen processing and presentation	2/904	77/7206	0.00479354039599
ko05169	Epstein-Barr virus infection	13/904	206/7206	0.00518711276086
ko04146	Peroxisome	3/904	89/7206	0.00545974212928
ko04750	Inflammatory mediator regulation of TRP channels	26/904	122/7206	0.00549390345746
ko04371	Apelin signaling pathway	35/904	177/7206	0.00550204303343
ko04930	Type II diabetes mellitus	14/904	54/7206	0.00626031407752
ko04540	Gap junction	27/904	128/7206	0.00644327858241
ko04964	Proximal tubule bicarbonate reclamation	9/904	29/7206	0.00715077144058
ko05162	Measles	6/904	120/7206	0.00801382923097
ko04064	NF-kappa B signaling pathway	4/904	96/7206	0.00803655394872
ko00562	Inositol phosphate metabolism	20/904	89/7206	0.00887663570199
ko03320	PPAR signaling pathway	2/904	69/7206	0.00973468522689
ko04810	Regulation of actin cytoskeleton	20/904	264/7206	0.0105120429688
ko04966	Collecting duct acid secretion	8/904	26/7206	0.0116518218192
ko00280	Valine, leucine and isoleucine degradation	1/904	54/7206	0.0117135945863
ko05110	Vibrio cholerae infection	15/904	63/7206	0.0117581059849
ko00480	Glutathione metabolism	1/904	55/7206	0.0120856790668
ko04626	Plant-pathogen interaction	6/904	18/7206	0.0187401693616
ko05215	Prostate cancer	6/904	111/7206	0.0199252216262
ko05224	Breast cancer	12/904	174/7206	0.0201690238574
ko04640	Hematopoietic cell lineage	2/904	64/7206	0.0206912252644
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/904	182/7206	0.0231564118765
ko00620	Pyruvate metabolism	1/904	46/7206	0.0251453220687
ko03420	Nucleotide excision repair	1/904	46/7206	0.0251453220687
ko00270	Cysteine and methionine metabolism	1/904	47/7206	0.0252485778806
ko00260	Glycine, serine and threonine metabolism	1/904	48/7206	0.0257972621169
ko05219	Bladder cancer	1/904	48/7206	0.0257972621169
ko04976	Bile secretion	17/904	80/7206	0.0258776734653
ko05161	Hepatitis B	12/904	173/7206	0.0263459946761
ko00230	Purine metabolism	35/904	194/7206	0.0271401481437
ko04978	Mineral absorption	10/904	40/7206	0.0275270552964
ko05200	Pathways in cancer	46/904	492/7206	0.0285276534163
ko05131	Shigellosis	4/904	82/7206	0.029388316595
ko04071	Sphingolipid signaling pathway	30/904	162/7206	0.0297428174536
ko00330	Arginine and proline metabolism	2/904	61/7206	0.0298441956535
ko04214	Apoptosis - fly	3/904	72/7206	0.0300478452236
ko04960	Aldosterone-regulated sodium reabsorption	10/904	41/7206	0.0310428637115
ko05410	Hypertrophic cardiomyopathy (HCM)	20/904	100/7206	0.0319251388706
ko04973	Carbohydrate digestion and absorption	10/904	42/7206	0.0351296181894
ko05231	Choline metabolism in cancer	25/904	134/7206	0.0353165645882
ko05034	Alcoholism	41/904	238/7206	0.0358730267435
ko03022	Basal transcription factors	1/904	44/7206	0.037264543594
ko00071	Fatty acid degradation	1/904	45/7206	0.0382188182571
ko05416	Viral myocarditis	2/904	55/7206	0.040779686469
ko05217	Basal cell carcinoma	3/904	68/7206	0.0415112062858
ko04630	Jak-STAT signaling pathway	9/904	132/7206	0.0459170590564
ko04142	Lysosome	11/904	151/7206	0.0469579364317
ko04510	Focal adhesion	20/904	240/7206	0.0469706786418
ko04918	Thyroid hormone synthesis	17/904	86/7206	0.0488532957703