ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1233	423/7206	9.81380755913e-57
ko04724	Glutamatergic synapse	95/1233	152/7206	1.06883947488e-36
ko05033	Nicotine addiction	50/1233	56/7206	2.2422650525e-32
ko04713	Circadian entrainment	82/1233	136/7206	3.66799936614e-30
ko05032	Morphine addiction	72/1233	110/7206	6.82051326194e-30
ko04727	GABAergic synapse	71/1233	110/7206	6.46154227277e-29
ko04728	Dopaminergic synapse	90/1233	185/7206	1.09833289748e-23
ko04725	Cholinergic synapse	80/1233	160/7206	3.9973299935e-22
ko04721	Synaptic vesicle cycle	52/1233	80/7206	1.12105078561e-21
ko04020	Calcium signaling pathway	108/1233	265/7206	1.99960999622e-20
ko04723	Retrograde endocannabinoid signaling	81/1233	175/7206	1.07969396255e-19
ko04024	cAMP signaling pathway	108/1233	279/7206	1.72776392711e-18
ko04911	Insulin secretion	61/1233	117/7206	2.72338609471e-18
ko04726	Serotonergic synapse	66/1233	137/7206	2.28696820744e-17
ko04921	Oxytocin signaling pathway	86/1233	209/7206	7.8177981872e-17
ko04744	Phototransduction	28/1233	36/7206	1.93601358772e-15
ko04742	Taste transduction	38/1233	61/7206	2.88670585634e-15
ko04720	Long-term potentiation	51/1233	99/7206	3.26365897304e-15
ko05031	Amphetamine addiction	47/1233	91/7206	3.56083517023e-14
ko04970	Salivary secretion	47/1233	95/7206	2.86664470088e-13
ko04261	Adrenergic signaling in cardiomyocytes	75/1233	205/7206	1.09963984744e-11
ko04740	Olfactory transduction	40/1233	80/7206	1.12801635396e-11
ko03040	Spliceosome	1/1233	145/7206	7.25152522695e-11
ko04925	Aldosterone synthesis and secretion	44/1233	105/7206	1.55611534532e-09
ko04971	Gastric acid secretion	41/1233	98/7206	5.97348339449e-09
ko04360	Axon guidance	75/1233	233/7206	1.36059378134e-08
ko04540	Gap junction	48/1233	128/7206	3.3409130885e-08
ko05030	Cocaine addiction	32/1233	73/7206	7.49936608469e-08
ko04022	cGMP-PKG signaling pathway	68/1233	216/7206	1.71880969165e-07
ko04070	Phosphatidylinositol signaling system	42/1233	112/7206	1.82902767735e-07
ko05168	Herpes simplex infection	8/1233	182/7206	2.21175412639e-07
ko04730	Long-term depression	32/1233	78/7206	4.78280734298e-07
ko05203	Viral carcinogenesis	19/1233	277/7206	5.24489917842e-07
ko03013	RNA transport	7/1233	166/7206	5.72863760339e-07
ko05322	Systemic lupus erythematosus	6/1233	151/7206	9.754632473e-07
ko04060	Cytokine-cytokine receptor interaction	10/1233	191/7206	1.2205000753e-06
ko04010	MAPK signaling pathway	88/1233	321/7206	2.18185388543e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1233	74/7206	2.3304421359e-06
ko04972	Pancreatic secretion	39/1233	111/7206	4.86005511055e-06
ko04621	NOD-like receptor signaling pathway	8/1233	157/7206	8.14837851775e-06
ko05164	Influenza A	9/1233	167/7206	9.10973913797e-06
ko04141	Protein processing in endoplasmic reticulum	11/1233	184/7206	9.77733622357e-06
ko04110	Cell cycle	7/1233	145/7206	1.04133330714e-05
ko04745	Phototransduction - fly	18/1233	38/7206	1.48392660373e-05
ko04966	Collecting duct acid secretion	14/1233	26/7206	2.14119719408e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1233	122/7206	4.82727536684e-05
ko04514	Cell adhesion molecules (CAMs)	41/1233	130/7206	4.82735036308e-05
ko05110	Vibrio cholerae infection	24/1233	63/7206	6.21051213053e-05
ko04924	Renin secretion	30/1233	86/7206	6.46928637322e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1233	59/7206	6.6227739426e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1233	79/7206	6.84971435604e-05
ko04612	Antigen processing and presentation	2/1233	77/7206	0.00010738314738
ko05169	Epstein-Barr virus infection	16/1233	206/7206	0.000108706965796
ko04610	Complement and coagulation cascades	2/1233	79/7206	0.000113366040439
ko03008	Ribosome biogenesis in eukaryotes	2/1233	79/7206	0.000113366040439
ko04014	Ras signaling pathway	72/1233	279/7206	0.000178075343728
ko05414	Dilated cardiomyopathy	35/1233	112/7206	0.000200753397051
ko04072	Phospholipase D signaling pathway	54/1233	197/7206	0.000239626158344
ko05162	Measles	7/1233	120/7206	0.00034103362275
ko04371	Apelin signaling pathway	49/1233	177/7206	0.000363583110252
ko04260	Cardiac muscle contraction	31/1233	98/7206	0.000366218740292
ko04146	Peroxisome	4/1233	89/7206	0.000549962724445
ko04912	GnRH signaling pathway	36/1233	122/7206	0.000600553754722
ko04915	Estrogen signaling pathway	38/1233	131/7206	0.000610873330469
ko04120	Ubiquitin mediated proteolysis	10/1233	138/7206	0.00123794697814
ko00240	Pyrimidine metabolism	7/1233	110/7206	0.00129081308001
ko04626	Plant-pathogen interaction	9/1233	18/7206	0.00135360926076
ko04976	Bile secretion	25/1233	80/7206	0.00156713721759
ko04923	Regulation of lipolysis in adipocytes	24/1233	77/7206	0.00209346050274
ko04916	Melanogenesis	39/1233	142/7206	0.0021548613356
ko04657	IL-17 signaling pathway	5/1233	87/7206	0.00243587445611
ko04064	NF-kappa B signaling pathway	6/1233	96/7206	0.00248293415107
ko03420	Nucleotide excision repair	1/1233	46/7206	0.00281801669935
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1233	182/7206	0.00366643497309
ko05321	Inflammatory bowel disease (IBD)	2/1233	56/7206	0.00375213283672
ko05205	Proteoglycans in cancer	29/1233	271/7206	0.00385442297217
ko03022	Basal transcription factors	1/1233	44/7206	0.00424895176302
ko05144	Malaria	1/1233	45/7206	0.00437422660431
ko00071	Fatty acid degradation	1/1233	45/7206	0.00437422660431
ko00310	Lysine degradation	4/1233	73/7206	0.00466499368609
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1233	14/7206	0.00474472881989
ko05140	Leishmaniasis	4/1233	75/7206	0.0048363150596
ko04918	Thyroid hormone synthesis	25/1233	86/7206	0.00563270137531
ko04330	Notch signaling pathway	3/1233	62/7206	0.00622520690091
ko04622	RIG-I-like receptor signaling pathway	3/1233	62/7206	0.00622520690091
ko05214	Glioma	23/1233	79/7206	0.00670762421219
ko04214	Apoptosis - fly	4/1233	72/7206	0.00671886890437
ko04015	Rap1 signaling pathway	65/1233	278/7206	0.00714298569879
ko05418	Fluid shear stress and atherosclerosis	17/1233	173/7206	0.00780374453887
ko00590	Arachidonic acid metabolism	2/1233	52/7206	0.00832932772397
ko04270	Vascular smooth muscle contraction	39/1233	154/7206	0.0090823211603
ko00562	Inositol phosphate metabolism	25/1233	89/7206	0.00995657936638
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1233	100/7206	0.0109766914234
ko04973	Carbohydrate digestion and absorption	14/1233	42/7206	0.0114464113886
ko05145	Toxoplasmosis	11/1233	126/7206	0.0115703680078
ko00260	Glycine, serine and threonine metabolism	2/1233	48/7206	0.011723014621
ko04922	Glucagon signaling pathway	33/1233	128/7206	0.0123878530503
ko03018	RNA degradation	6/1233	84/7206	0.0124928063995
ko04115	p53 signaling pathway	5/1233	74/7206	0.0129254517531
ko01524	Platinum drug resistance	5/1233	76/7206	0.0131937221548
ko04630	Jak-STAT signaling pathway	12/1233	132/7206	0.0136521846241
ko05231	Choline metabolism in cancer	34/1233	134/7206	0.0145213022533
ko05016	Huntington's disease	24/1233	215/7206	0.0167436077601
ko05166	HTLV-I infection	35/1233	292/7206	0.0171069599356
ko05131	Shigellosis	6/1233	82/7206	0.0172127319952
ko05161	Hepatitis B	18/1233	173/7206	0.0182295399482
ko00480	Glutathione metabolism	3/1233	55/7206	0.0182606561684
ko04640	Hematopoietic cell lineage	4/1233	64/7206	0.0184237047169
ko04658	Th1 and Th2 cell differentiation	8/1233	96/7206	0.0197285704467
ko04960	Aldosterone-regulated sodium reabsorption	13/1233	41/7206	0.0202228450742
ko05133	Pertussis	7/1233	87/7206	0.021396204615
ko00860	Porphyrin and chlorophyll metabolism	1/1233	34/7206	0.0216117428674
ko04062	Chemokine signaling pathway	47/1233	201/7206	0.0221309253463
ko04964	Proximal tubule bicarbonate reclamation	10/1233	29/7206	0.0224173468284
ko05034	Alcoholism	54/1233	238/7206	0.0228467318695
ko03320	PPAR signaling pathway	5/1233	69/7206	0.0244784029872
ko00330	Arginine and proline metabolism	4/1233	61/7206	0.0255226482359
ko04114	Oocyte meiosis	34/1233	139/7206	0.0298308239626
ko04620	Toll-like receptor signaling pathway	9/1233	100/7206	0.0314126055793
ko04217	Necroptosis	20/1233	178/7206	0.0341656965483
ko00140	Steroid hormone biosynthesis	2/1233	41/7206	0.035960867837
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1233	40/7206	0.0359611222678
ko04668	TNF signaling pathway	12/1233	120/7206	0.0372081182163
ko04710	Circadian rhythm	13/1233	43/7206	0.0387780591552
ko05132	Salmonella infection	9/1233	98/7206	0.041438551524
ko05215	Prostate cancer	11/1233	111/7206	0.0418781632561
ko05222	Small cell lung cancer	8/1233	89/7206	0.0460024407902
ko04350	TGF-beta signaling pathway	10/1233	103/7206	0.0472677578212
ko05320	Autoimmune thyroid disease	1/1233	29/7206	0.0481564148871