ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1166	423/7206	1.42731737721e-51
ko04724	Glutamatergic synapse	88/1166	152/7206	2.40202328448e-32
ko05033	Nicotine addiction	48/1166	56/7206	1.77722716936e-30
ko04727	GABAergic synapse	67/1166	110/7206	1.19255132568e-26
ko04713	Circadian entrainment	75/1166	136/7206	7.92984201167e-26
ko05032	Morphine addiction	66/1166	110/7206	9.95129435534e-26
ko04721	Synaptic vesicle cycle	50/1166	80/7206	7.00375157797e-21
ko04725	Cholinergic synapse	75/1166	160/7206	3.51098630927e-20
ko04728	Dopaminergic synapse	81/1166	185/7206	2.0966730015e-19
ko04723	Retrograde endocannabinoid signaling	77/1166	175/7206	1.18932075475e-18
ko04742	Taste transduction	40/1166	61/7206	4.79627973339e-18
ko04744	Phototransduction	29/1166	36/7206	2.23622130002e-17
ko04024	cAMP signaling pathway	102/1166	279/7206	3.07683250735e-17
ko04726	Serotonergic synapse	61/1166	137/7206	2.62291584823e-15
ko04911	Insulin secretion	54/1166	117/7206	1.68655505369e-14
ko04020	Calcium signaling pathway	92/1166	265/7206	4.87068278619e-14
ko04740	Olfactory transduction	42/1166	80/7206	5.58989271592e-14
ko04921	Oxytocin signaling pathway	74/1166	209/7206	5.503681705e-12
ko04720	Long-term potentiation	43/1166	99/7206	9.7800603486e-11
ko05031	Amphetamine addiction	40/1166	91/7206	2.85338490914e-10
ko04261	Adrenergic signaling in cardiomyocytes	67/1166	205/7206	3.31989868659e-09
ko03040	Spliceosome	2/1166	145/7206	4.03460927248e-09
ko05203	Viral carcinogenesis	14/1166	277/7206	9.77766641183e-09
ko04970	Salivary secretion	38/1166	95/7206	1.94275783733e-08
ko04925	Aldosterone synthesis and secretion	39/1166	105/7206	1.44384046343e-07
ko04971	Gastric acid secretion	37/1166	98/7206	2.03131397196e-07
ko05164	Influenza A	6/1166	167/7206	3.56567026392e-07
ko05322	Systemic lupus erythematosus	5/1166	151/7206	8.95967376265e-07
ko05168	Herpes simplex infection	8/1166	182/7206	1.07876845662e-06
ko05030	Cocaine addiction	29/1166	73/7206	1.1062771053e-06
ko04745	Phototransduction - fly	19/1166	38/7206	1.29945040806e-06
ko04966	Collecting duct acid secretion	15/1166	26/7206	1.64407138421e-06
ko03013	RNA transport	7/1166	166/7206	1.90349126151e-06
ko04060	Cytokine-cytokine receptor interaction	10/1166	191/7206	5.36697413201e-06
ko04120	Ubiquitin mediated proteolysis	5/1166	138/7206	5.91025813624e-06
ko04621	NOD-like receptor signaling pathway	7/1166	157/7206	8.19289511786e-06
ko04514	Cell adhesion molecules (CAMs)	41/1166	130/7206	1.06065626301e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1166	74/7206	1.87946284136e-05
ko04972	Pancreatic secretion	36/1166	111/7206	2.06739804536e-05
ko04070	Phosphatidylinositol signaling system	36/1166	112/7206	2.38275822295e-05
ko04141	Protein processing in endoplasmic reticulum	11/1166	184/7206	4.01179197463e-05
ko05110	Vibrio cholerae infection	23/1166	63/7206	8.34428102762e-05
ko04976	Bile secretion	27/1166	80/7206	9.33841469571e-05
ko05205	Proteoglycans in cancer	22/1166	271/7206	9.98888020785e-05
ko04360	Axon guidance	60/1166	233/7206	0.000133614988159
ko04110	Cell cycle	8/1166	145/7206	0.000139867736757
ko05161	Hepatitis B	11/1166	173/7206	0.000143036990455
ko04730	Long-term depression	26/1166	78/7206	0.000155353284687
ko03008	Ribosome biogenesis in eukaryotes	2/1166	79/7206	0.000172656326145
ko04022	cGMP-PKG signaling pathway	56/1166	216/7206	0.000222851597622
ko05162	Measles	6/1166	120/7206	0.000245981942464
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1166	79/7206	0.000285225386511
ko05166	HTLV-I infection	26/1166	292/7206	0.000331171037603
ko04010	MAPK signaling pathway	76/1166	321/7206	0.00034684743327
ko04072	Phospholipase D signaling pathway	51/1166	197/7206	0.000382000701183
ko05140	Leishmaniasis	2/1166	75/7206	0.000387460864271
ko04064	NF-kappa B signaling pathway	4/1166	96/7206	0.000404912890374
ko04260	Cardiac muscle contraction	30/1166	98/7206	0.000430853010302
ko04750	Inflammatory mediator regulation of TRP channels	35/1166	122/7206	0.00043755054774
ko05169	Epstein-Barr virus infection	16/1166	206/7206	0.000495364387998
ko04924	Renin secretion	26/1166	86/7206	0.0009962358799
ko04964	Proximal tubule bicarbonate reclamation	12/1166	29/7206	0.00107130879432
ko04146	Peroxisome	4/1166	89/7206	0.00121045729927
ko00520	Amino sugar and nucleotide sugar metabolism	1/1166	55/7206	0.00133730743218
ko00480	Glutathione metabolism	1/1166	55/7206	0.00133730743218
ko04540	Gap junction	35/1166	128/7206	0.00143655723893
ko04612	Antigen processing and presentation	3/1166	77/7206	0.00153787115668
ko04014	Ras signaling pathway	65/1166	279/7206	0.00157365639964
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1166	182/7206	0.00211076681077
ko04915	Estrogen signaling pathway	34/1166	131/7206	0.0037922004587
ko05414	Dilated cardiomyopathy	30/1166	112/7206	0.00405423160522
ko04626	Plant-pathogen interaction	8/1166	18/7206	0.00437546388608
ko03420	Nucleotide excision repair	1/1166	46/7206	0.00445501073442
ko05016	Huntington's disease	20/1166	215/7206	0.00458354577373
ko04658	Th1 and Th2 cell differentiation	6/1166	96/7206	0.00499899379012
ko04610	Complement and coagulation cascades	4/1166	79/7206	0.0050121491208
ko04657	IL-17 signaling pathway	5/1166	87/7206	0.00501832878282
ko05321	Inflammatory bowel disease (IBD)	2/1166	56/7206	0.00572742020125
ko03022	Basal transcription factors	1/1166	44/7206	0.00668703144905
ko05144	Malaria	1/1166	45/7206	0.00687968612589
ko00071	Fatty acid degradation	1/1166	45/7206	0.00687968612589
ko04668	TNF signaling pathway	9/1166	120/7206	0.0081003116298
ko00240	Pyrimidine metabolism	8/1166	110/7206	0.00856123794856
ko04214	Apoptosis - fly	4/1166	72/7206	0.00967649957636
ko05131	Shigellosis	5/1166	82/7206	0.00971236468601
ko00310	Lysine degradation	4/1166	73/7206	0.00975355886369
ko05145	Toxoplasmosis	10/1166	126/7206	0.00984939821823
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1166	59/7206	0.012391392563
ko00590	Arachidonic acid metabolism	2/1166	52/7206	0.0124494281871
ko04371	Apelin signaling pathway	41/1166	177/7206	0.0130945679459
ko04622	RIG-I-like receptor signaling pathway	3/1166	62/7206	0.013767796253
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1166	14/7206	0.0164899985163
ko05206	MicroRNAs in cancer	17/1166	177/7206	0.0169020904744
ko05219	Bladder cancer	2/1166	48/7206	0.0176709296429
ko01524	Platinum drug resistance	5/1166	76/7206	0.0184035588536
ko05215	Prostate cancer	9/1166	111/7206	0.018684357808
ko04350	TGF-beta signaling pathway	8/1166	103/7206	0.0208650497943
ko05418	Fluid shear stress and atherosclerosis	17/1166	173/7206	0.0210536731327
ko04210	Apoptosis	18/1166	180/7206	0.023553813335
ko00910	Nitrogen metabolism	7/1166	19/7206	0.0240074738565
ko03018	RNA degradation	6/1166	84/7206	0.0241068348819
ko04115	p53 signaling pathway	5/1166	74/7206	0.0253072838994
ko04912	GnRH signaling pathway	29/1166	122/7206	0.0256001038083
ko04930	Type II diabetes mellitus	15/1166	54/7206	0.0259149993478
ko04640	Hematopoietic cell lineage	4/1166	64/7206	0.0262706709364
ko04620	Toll-like receptor signaling pathway	8/1166	100/7206	0.0274595851699
ko04923	Regulation of lipolysis in adipocytes	20/1166	77/7206	0.0278686506612
ko00860	Porphyrin and chlorophyll metabolism	1/1166	34/7206	0.0334246790597
ko00500	Starch and sucrose metabolism	1/1166	35/7206	0.0345471785808
ko00330	Arginine and proline metabolism	4/1166	61/7206	0.0363691005646
ko04330	Notch signaling pathway	4/1166	62/7206	0.0364495640384
ko00280	Valine, leucine and isoleucine degradation	3/1166	54/7206	0.0386623092271
ko05133	Pertussis	7/1166	87/7206	0.0393176102079
ko00562	Inositol phosphate metabolism	22/1166	89/7206	0.040901678497
ko04140	Autophagy - animal	17/1166	164/7206	0.0412226727992
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1166	92/7206	0.0466091267925
ko03015	mRNA surveillance pathway	8/1166	93/7206	0.0466572749041
ko05217	Basal cell carcinoma	5/1166	68/7206	0.0466580967659
ko03320	PPAR signaling pathway	5/1166	69/7206	0.0470638646368
ko04217	Necroptosis	19/1166	178/7206	0.0494280457726