ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	190/1149	423/7206	2.11469011413e-48
ko04724	Glutamatergic synapse	85/1149	152/7206	3.11148083347e-30
ko05033	Nicotine addiction	46/1149	56/7206	6.73610856741e-28
ko05032	Morphine addiction	63/1149	110/7206	2.02235110867e-23
ko04721	Synaptic vesicle cycle	52/1149	80/7206	3.86388408503e-23
ko04727	GABAergic synapse	60/1149	110/7206	7.03007114012e-21
ko04713	Circadian entrainment	68/1149	136/7206	1.05240303227e-20
ko04728	Dopaminergic synapse	82/1149	185/7206	1.84481509716e-20
ko04725	Cholinergic synapse	73/1149	160/7206	3.30013393243e-19
ko04024	cAMP signaling pathway	101/1149	279/7206	3.85752375743e-17
ko04723	Retrograde endocannabinoid signaling	72/1149	175/7206	5.93629897804e-16
ko04020	Calcium signaling pathway	94/1149	265/7206	1.8824874552e-15
ko04742	Taste transduction	36/1149	61/7206	1.8139798953e-14
ko04726	Serotonergic synapse	58/1149	137/7206	9.95641369888e-14
ko04921	Oxytocin signaling pathway	76/1149	209/7206	3.18028350162e-13
ko04911	Insulin secretion	51/1149	117/7206	8.10395376018e-13
ko04744	Phototransduction	24/1149	36/7206	1.05602788432e-11
ko04261	Adrenergic signaling in cardiomyocytes	70/1149	205/7206	8.52736090213e-11
ko05031	Amphetamine addiction	40/1149	91/7206	1.80319655323e-10
ko04720	Long-term potentiation	42/1149	99/7206	2.48007695021e-10
ko03040	Spliceosome	1/1149	145/7206	5.2492262568e-10
ko05203	Viral carcinogenesis	13/1149	277/7206	4.58084227026e-09
ko04970	Salivary secretion	38/1149	95/7206	1.2857420819e-08
ko04360	Axon guidance	70/1149	233/7206	4.55184707804e-08
ko05168	Herpes simplex infection	6/1149	182/7206	8.61520848679e-08
ko04966	Collecting duct acid secretion	16/1149	26/7206	1.71179847441e-07
ko04971	Gastric acid secretion	36/1149	98/7206	4.27196589671e-07
ko04740	Olfactory transduction	31/1149	80/7206	6.48991275924e-07
ko04060	Cytokine-cytokine receptor interaction	9/1149	191/7206	1.7604603252e-06
ko04621	NOD-like receptor signaling pathway	6/1149	157/7206	2.38902270654e-06
ko03013	RNA transport	7/1149	166/7206	2.80905863461e-06
ko05164	Influenza A	7/1149	167/7206	2.84288539523e-06
ko04925	Aldosterone synthesis and secretion	36/1149	105/7206	2.85645218906e-06
ko04022	cGMP-PKG signaling pathway	61/1149	216/7206	4.34766713324e-06
ko05322	Systemic lupus erythematosus	6/1149	151/7206	4.95399772033e-06
ko04514	Cell adhesion molecules (CAMs)	41/1149	130/7206	8.46636868118e-06
ko04010	MAPK signaling pathway	81/1149	321/7206	1.10037040638e-05
ko05030	Cocaine addiction	27/1149	73/7206	1.24320326159e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1149	74/7206	1.51953928756e-05
ko04924	Renin secretion	30/1149	86/7206	1.72311737408e-05
ko04120	Ubiquitin mediated proteolysis	6/1149	138/7206	3.03197888996e-05
ko04070	Phosphatidylinositol signaling system	35/1149	112/7206	4.16070459934e-05
ko04110	Cell cycle	7/1149	145/7206	4.80084824085e-05
ko04141	Protein processing in endoplasmic reticulum	11/1149	184/7206	5.65562903845e-05
ko04730	Long-term depression	27/1149	78/7206	5.74065349806e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1149	79/7206	6.56449984907e-05
ko05169	Epstein-Barr virus infection	14/1149	206/7206	9.76608195529e-05
ko04745	Phototransduction - fly	16/1149	38/7206	0.00010633874866
ko04972	Pancreatic secretion	34/1149	111/7206	0.000109141685171
ko04064	NF-kappa B signaling pathway	3/1149	96/7206	0.000110552596944
ko04014	Ras signaling pathway	69/1149	279/7206	0.000112046176544
ko04260	Cardiac muscle contraction	31/1149	98/7206	0.000122280439519
ko04540	Gap junction	37/1149	128/7206	0.000204025218678
ko04610	Complement and coagulation cascades	2/1149	79/7206	0.000269489541031
ko03008	Ribosome biogenesis in eukaryotes	2/1149	79/7206	0.000269489541031
ko05140	Leishmaniasis	2/1149	75/7206	0.000387237299382
ko04612	Antigen processing and presentation	2/1149	77/7206	0.00041271336742
ko05161	Hepatitis B	12/1149	173/7206	0.000477926605219
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1149	14/7206	0.000496628516684
ko05414	Dilated cardiomyopathy	32/1149	112/7206	0.000618764593198
ko05205	Proteoglycans in cancer	24/1149	271/7206	0.000681241101171
ko05110	Vibrio cholerae infection	21/1149	63/7206	0.000708047282599
ko04964	Proximal tubule bicarbonate reclamation	12/1149	29/7206	0.000936441446522
ko05162	Measles	7/1149	120/7206	0.0010025885088
ko04072	Phospholipase D signaling pathway	49/1149	197/7206	0.00104220079403
ko00480	Glutathione metabolism	1/1149	55/7206	0.00132754723839
ko04976	Bile secretion	24/1149	80/7206	0.00172740930727
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1149	59/7206	0.00184504628841
ko00590	Arachidonic acid metabolism	1/1149	52/7206	0.00199489971217
ko04330	Notch signaling pathway	2/1149	62/7206	0.00270127162116
ko04214	Apoptosis - fly	3/1149	72/7206	0.00319480841434
ko05166	HTLV-I infection	29/1149	292/7206	0.00321840060597
ko00562	Inositol phosphate metabolism	25/1149	89/7206	0.00322657586424
ko00310	Lysine degradation	3/1149	73/7206	0.00326160956404
ko00240	Pyrimidine metabolism	7/1149	110/7206	0.00361039915543
ko04750	Inflammatory mediator regulation of TRP channels	32/1149	122/7206	0.00373113697788
ko04626	Plant-pathogen interaction	8/1149	18/7206	0.00398307045221
ko04146	Peroxisome	5/1149	89/7206	0.00511746927198
ko04915	Estrogen signaling pathway	33/1149	131/7206	0.0054046233517
ko04371	Apelin signaling pathway	42/1149	177/7206	0.00656497367273
ko03022	Basal transcription factors	1/1149	44/7206	0.00676167254138
ko00071	Fatty acid degradation	1/1149	45/7206	0.00680065774471
ko01524	Platinum drug resistance	4/1149	76/7206	0.00695692485775
ko03420	Nucleotide excision repair	1/1149	46/7206	0.00707691921808
ko04922	Glucagon signaling pathway	32/1149	128/7206	0.00709376979887
ko04210	Apoptosis	16/1149	180/7206	0.00712232387311
ko04657	IL-17 signaling pathway	5/1149	87/7206	0.00723665135963
ko04668	TNF signaling pathway	9/1149	120/7206	0.00803298639901
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1149	100/7206	0.00859038253862
ko05321	Inflammatory bowel disease (IBD)	2/1149	56/7206	0.00886799319781
ko05145	Toxoplasmosis	10/1149	126/7206	0.0133344452163
ko00330	Arginine and proline metabolism	3/1149	61/7206	0.0133598619391
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1149	182/7206	0.0133797871587
ko04622	RIG-I-like receptor signaling pathway	3/1149	62/7206	0.0135068527971
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1149	40/7206	0.0152774374265
ko00140	Steroid hormone biosynthesis	1/1149	41/7206	0.0159536679019
ko04217	Necroptosis	17/1149	178/7206	0.0167843874221
ko05206	MicroRNAs in cancer	17/1149	177/7206	0.0167847069404
ko05133	Pertussis	6/1149	87/7206	0.017709381101
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1149	92/7206	0.0215530449977
ko00910	Nitrogen metabolism	7/1149	19/7206	0.0222657218688
ko00982	Drug metabolism - cytochrome P450	1/1149	37/7206	0.0225849533869
ko00630	Glyoxylate and dicarboxylate metabolism	1/1149	38/7206	0.0232779716741
ko03410	Base excision repair	1/1149	38/7206	0.0232779716741
ko03018	RNA degradation	6/1149	84/7206	0.0239381011997
ko04115	p53 signaling pathway	5/1149	74/7206	0.0254325376073
ko04923	Regulation of lipolysis in adipocytes	20/1149	77/7206	0.026699878335
ko05418	Fluid shear stress and atherosclerosis	17/1149	173/7206	0.0267039250441
ko00260	Glycine, serine and threonine metabolism	2/1149	48/7206	0.0268391870495
ko05131	Shigellosis	6/1149	82/7206	0.0324583483499
ko04973	Carbohydrate digestion and absorption	12/1149	42/7206	0.0332731107468
ko00500	Starch and sucrose metabolism	1/1149	35/7206	0.0340944395881
ko05016	Huntington's disease	23/1149	215/7206	0.036836040096
ko04640	Hematopoietic cell lineage	4/1149	64/7206	0.037438973036
ko00280	Valine, leucine and isoleucine degradation	3/1149	54/7206	0.0380962331489
ko05144	Malaria	2/1149	45/7206	0.0381067142483
ko00512	Mucin type O-glycan biosynthesis	9/1149	29/7206	0.0381936065822
ko05222	Small cell lung cancer	7/1149	89/7206	0.0399337595917
ko04350	TGF-beta signaling pathway	9/1149	103/7206	0.042090876002
ko05231	Choline metabolism in cancer	30/1149	134/7206	0.0431824570856
ko05202	Transcriptional misregulation in cancer	20/1149	188/7206	0.0434271906657
ko04912	GnRH signaling pathway	28/1149	122/7206	0.0447340702422
ko03320	PPAR signaling pathway	5/1149	69/7206	0.0469501694337
ko04658	Th1 and Th2 cell differentiation	8/1149	96/7206	0.0478323393193
ko04510	Focal adhesion	27/1149	240/7206	0.0479578321939
ko05200	Pathways in cancer	63/1149	492/7206	0.0480795251102
ko05215	Prostate cancer	10/1149	111/7206	0.0489060098192