ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1314	423/7206	1.03420178261e-51
ko04724	Glutamatergic synapse	92/1314	152/7206	1.17863177417e-31
ko05033	Nicotine addiction	47/1314	56/7206	1.26336295251e-26
ko04713	Circadian entrainment	80/1314	136/7206	1.89531349369e-26
ko05032	Morphine addiction	68/1314	110/7206	2.09535387371e-24
ko04727	GABAergic synapse	66/1314	110/7206	1.12274915525e-22
ko04721	Synaptic vesicle cycle	53/1314	80/7206	2.55019944966e-21
ko04728	Dopaminergic synapse	87/1314	185/7206	9.56773213903e-20
ko04020	Calcium signaling pathway	110/1314	265/7206	2.93502097022e-19
ko04725	Cholinergic synapse	78/1314	160/7206	5.55342729582e-19
ko04024	cAMP signaling pathway	108/1314	279/7206	3.12115930151e-16
ko04742	Taste transduction	40/1314	61/7206	3.72278831984e-16
ko04911	Insulin secretion	59/1314	117/7206	1.67043407327e-15
ko04723	Retrograde endocannabinoid signaling	77/1314	175/7206	1.74331966947e-15
ko04921	Oxytocin signaling pathway	86/1314	209/7206	4.32097514683e-15
ko04726	Serotonergic synapse	63/1314	137/7206	4.80879346506e-14
ko04740	Olfactory transduction	44/1314	80/7206	1.26466042318e-13
ko04744	Phototransduction	27/1314	36/7206	1.5175030158e-13
ko04970	Salivary secretion	47/1314	95/7206	3.18621901871e-12
ko04720	Long-term potentiation	47/1314	99/7206	2.06757920737e-11
ko04261	Adrenergic signaling in cardiomyocytes	77/1314	205/7206	3.84849752373e-11
ko05031	Amphetamine addiction	44/1314	91/7206	4.22727100009e-11
ko03040	Spliceosome	2/1314	145/7206	1.36231279083e-10
ko04022	cGMP-PKG signaling pathway	76/1314	216/7206	1.67441127775e-09
ko05168	Herpes simplex infection	7/1314	182/7206	7.55884291982e-09
ko05203	Viral carcinogenesis	18/1314	277/7206	1.73931890225e-08
ko04925	Aldosterone synthesis and secretion	43/1314	105/7206	5.34744908001e-08
ko04360	Axon guidance	75/1314	233/7206	1.63879397706e-07
ko05322	Systemic lupus erythematosus	6/1314	151/7206	1.81736386832e-07
ko04971	Gastric acid secretion	40/1314	98/7206	1.85528596336e-07
ko03013	RNA transport	8/1314	166/7206	3.92145014713e-07
ko04060	Cytokine-cytokine receptor interaction	11/1314	191/7206	5.44544319801e-07
ko04540	Gap junction	47/1314	128/7206	6.40150820866e-07
ko04924	Renin secretion	35/1314	86/7206	1.41914056937e-06
ko05030	Cocaine addiction	31/1314	73/7206	1.6056095854e-06
ko04966	Collecting duct acid secretion	15/1314	26/7206	7.76417982525e-06
ko04120	Ubiquitin mediated proteolysis	7/1314	138/7206	9.68509574114e-06
ko04110	Cell cycle	8/1314	145/7206	1.02385290918e-05
ko04976	Bile secretion	31/1314	80/7206	1.38163205788e-05
ko04260	Cardiac muscle contraction	36/1314	98/7206	1.49381295305e-05
ko05164	Influenza A	11/1314	167/7206	1.68177450437e-05
ko04141	Protein processing in endoplasmic reticulum	13/1314	184/7206	1.69833910086e-05
ko04972	Pancreatic secretion	39/1314	111/7206	1.80074280528e-05
ko05169	Epstein-Barr virus infection	16/1314	206/7206	2.16372633152e-05
ko04730	Long-term depression	30/1314	78/7206	2.2305838424e-05
ko04621	NOD-like receptor signaling pathway	10/1314	157/7206	2.29817445208e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1314	74/7206	2.33168235618e-05
ko04745	Phototransduction - fly	18/1314	38/7206	3.65191123338e-05
ko04964	Proximal tubule bicarbonate reclamation	15/1314	29/7206	4.49243878995e-05
ko04514	Cell adhesion molecules (CAMs)	43/1314	130/7206	4.5032422502e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1314	79/7206	4.61661425886e-05
ko05140	Leishmaniasis	2/1314	75/7206	6.45377569461e-05
ko04064	NF-kappa B signaling pathway	4/1314	96/7206	8.03585565149e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1314	79/7206	9.37246664764e-05
ko04010	MAPK signaling pathway	86/1314	321/7206	0.000110474584495
ko04610	Complement and coagulation cascades	3/1314	79/7206	0.000196140634143
ko04612	Antigen processing and presentation	3/1314	77/7206	0.000289076583427
ko05414	Dilated cardiomyopathy	36/1314	112/7206	0.000309478467299
ko05205	Proteoglycans in cancer	28/1314	271/7206	0.000387134664425
ko05162	Measles	8/1314	120/7206	0.000458933319669
ko04014	Ras signaling pathway	74/1314	279/7206	0.000473202666249
ko05110	Vibrio cholerae infection	23/1314	63/7206	0.00048459401328
ko04371	Apelin signaling pathway	51/1314	177/7206	0.000504888007608
ko04750	Inflammatory mediator regulation of TRP channels	38/1314	122/7206	0.000516130089917
ko04214	Apoptosis - fly	3/1314	72/7206	0.000622963579458
ko04923	Regulation of lipolysis in adipocytes	26/1314	77/7206	0.000943530977802
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1314	14/7206	0.00126434262661
ko05161	Hepatitis B	16/1314	173/7206	0.00131819402733
ko04072	Phospholipase D signaling pathway	54/1314	197/7206	0.00136673620484
ko00240	Pyrimidine metabolism	8/1314	110/7206	0.00166242497223
ko03420	Nucleotide excision repair	1/1314	46/7206	0.00174498780843
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1314	59/7206	0.00179274792018
ko04070	Phosphatidylinositol signaling system	34/1314	112/7206	0.00181351983794
ko04626	Plant-pathogen interaction	9/1314	18/7206	0.00216195185428
ko00310	Lysine degradation	4/1314	73/7206	0.00217033803465
ko05131	Shigellosis	5/1314	82/7206	0.00228488171298
ko04922	Glucagon signaling pathway	37/1314	128/7206	0.00258065971925
ko03022	Basal transcription factors	1/1314	44/7206	0.00266262230439
ko04915	Estrogen signaling pathway	38/1314	131/7206	0.00272490038185
ko00071	Fatty acid degradation	1/1314	45/7206	0.00280481733842
ko04146	Peroxisome	6/1314	89/7206	0.00331307958697
ko05145	Toxoplasmosis	11/1314	126/7206	0.00349174331225
ko04930	Type II diabetes mellitus	19/1314	54/7206	0.00378422733196
ko05410	Hypertrophic cardiomyopathy (HCM)	30/1314	100/7206	0.00380377224795
ko05166	HTLV-I infection	35/1314	292/7206	0.00408853742593
ko04330	Notch signaling pathway	3/1314	62/7206	0.00424141735495
ko04622	RIG-I-like receptor signaling pathway	3/1314	62/7206	0.00424141735495
ko04657	IL-17 signaling pathway	6/1314	87/7206	0.0046640077763
ko04210	Apoptosis	19/1314	180/7206	0.00595200644841
ko01524	Platinum drug resistance	5/1314	76/7206	0.0064800287188
ko04668	TNF signaling pathway	11/1314	120/7206	0.00826441912832
ko04270	Vascular smooth muscle contraction	41/1314	154/7206	0.00830238159843
ko05321	Inflammatory bowel disease (IBD)	3/1314	56/7206	0.00849973639321
ko04710	Circadian rhythm	15/1314	43/7206	0.00868261381623
ko04115	p53 signaling pathway	5/1314	74/7206	0.00916319460144
ko00630	Glyoxylate and dicarboxylate metabolism	1/1314	38/7206	0.00957273871858
ko03410	Base excision repair	1/1314	38/7206	0.00957273871858
ko04658	Th1 and Th2 cell differentiation	8/1314	96/7206	0.0107250735207
ko05133	Pertussis	7/1314	87/7206	0.0112907745371
ko04978	Mineral absorption	14/1314	40/7206	0.0117085210158
ko00480	Glutathione metabolism	3/1314	55/7206	0.012643250952
ko04620	Toll-like receptor signaling pathway	9/1314	100/7206	0.013002953765
ko03018	RNA degradation	7/1314	84/7206	0.0152388233389
ko05217	Basal cell carcinoma	5/1314	68/7206	0.0171161345315
ko04912	GnRH signaling pathway	33/1314	122/7206	0.0172672615879
ko00590	Arachidonic acid metabolism	3/1314	52/7206	0.0176503037603
ko05200	Pathways in cancer	70/1314	492/7206	0.0181625454395
ko05215	Prostate cancer	11/1314	111/7206	0.0186338186893
ko04916	Melanogenesis	37/1314	142/7206	0.0205257375323
ko04350	TGF-beta signaling pathway	10/1314	103/7206	0.0206801817348
ko05212	Pancreatic cancer	7/1314	83/7206	0.0209917717782
ko05418	Fluid shear stress and atherosclerosis	20/1314	173/7206	0.0214508312256
ko04630	Jak-STAT signaling pathway	14/1314	132/7206	0.0222574462258
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1314	40/7206	0.023907855031
ko04142	Lysosome	17/1314	151/7206	0.0248277426579
ko05340	Primary immunodeficiency	1/1314	30/7206	0.0312356538152
ko04932	Non-alcoholic fatty liver disease (NAFLD)	22/1314	182/7206	0.0318768211287
ko04974	Protein digestion and absorption	26/1314	96/7206	0.0321743789645
ko00600	Sphingolipid metabolism	5/1314	63/7206	0.0323355894905
ko00280	Valine, leucine and isoleucine degradation	4/1314	54/7206	0.0342501541084
ko05132	Salmonella infection	10/1314	98/7206	0.0353085237613
ko05219	Bladder cancer	3/1314	48/7206	0.0364838470369
ko00562	Inositol phosphate metabolism	24/1314	89/7206	0.0378467819779
ko04217	Necroptosis	22/1314	178/7206	0.0389813309741
ko04113	Meiosis - yeast	6/1314	70/7206	0.0413915724671
ko04213	Longevity regulating pathway - multiple species	23/1314	86/7206	0.0482886458089
ko05320	Autoimmune thyroid disease	1/1314	29/7206	0.0490904541762