ko pathway ratio_in_study ratio_in_pop p_value ko03030 DNA replication 19/214 38/7206 9.2730708167e-20 ko04110 Cell cycle 30/214 145/7206 1.08293238422e-17 ko03460 Fanconi anemia pathway 17/214 51/7206 3.49122844865e-14 ko03040 Spliceosome 25/214 145/7206 5.60940574814e-13 ko00240 Pyrimidine metabolism 20/214 110/7206 4.89332503061e-11 ko03440 Homologous recombination 13/214 41/7206 8.22143587114e-11 ko04111 Cell cycle - yeast 18/214 90/7206 9.06777841324e-11 ko03430 Mismatch repair 10/214 22/7206 2.05055002509e-10 ko04113 Meiosis - yeast 14/214 70/7206 1.2060648346e-08 ko03420 Nucleotide excision repair 11/214 46/7206 6.56266451573e-08 ko03410 Base excision repair 10/214 38/7206 9.88005470294e-08 ko04115 p53 signaling pathway 11/214 74/7206 9.89987202904e-06 ko00230 Purine metabolism 18/214 194/7206 1.62660630044e-05 ko04218 Cellular senescence 17/214 177/7206 1.79401428896e-05 ko03013 RNA transport 14/214 166/7206 0.0003952771934 ko00670 One carbon pool by folate 4/214 20/7206 0.00252003443571 ko05166 HTLV-I infection 18/214 292/7206 0.00384881125213 ko05203 Viral carcinogenesis 17/214 277/7206 0.00547325293813 ko01523 Antifolate resistance 4/214 30/7206 0.0113090882377 ko04914 Progesterone-mediated oocyte maturation 8/214 104/7206 0.011905808255 ko05222 Small cell lung cancer 7/214 89/7206 0.0162535982593 ko03015 mRNA surveillance pathway 7/214 93/7206 0.0202488504163 ko00480 Glutathione metabolism 5/214 55/7206 0.0230235277675 ko05168 Herpes simplex infection 11/214 182/7206 0.0232616478987 ko05212 Pancreatic cancer 6/214 83/7206 0.0363511915569 ko05161 Hepatitis B 10/214 173/7206 0.0380549758356 ko03018 RNA degradation 6/214 84/7206 0.0382174711502 ko05210 Colorectal cancer 6/214 86/7206 0.0421309740459 ko04060 Cytokine-cytokine receptor interaction 1/214 191/7206 0.047072686166 ko04144 Endocytosis 4/214 342/7206 0.0478517071595