ko pathway ratio_in_study ratio_in_pop p_value ko00120 Primary bile acid biosynthesis 10/512 20/7206 2.90210251591e-07 ko00350 Tyrosine metabolism 11/512 33/7206 9.61295592826e-06 ko00643 Styrene degradation 4/512 4/7206 2.52094550501e-05 ko04710 Circadian rhythm 12/512 43/7206 2.91057271577e-05 ko04020 Calcium signaling pathway 37/512 265/7206 7.0749731404e-05 ko00140 Steroid hormone biosynthesis 11/512 41/7206 9.31163675611e-05 ko04925 Aldosterone synthesis and secretion 18/512 105/7206 0.00037892301374 ko00051 Fructose and mannose metabolism 10/512 42/7206 0.0005553053461 ko03013 RNA transport 2/512 166/7206 0.000665728033684 ko04120 Ubiquitin mediated proteolysis 1/512 138/7206 0.000668298904884 ko04070 Phosphatidylinositol signaling system 18/512 112/7206 0.00108557888685 ko04610 Complement and coagulation cascades 14/512 79/7206 0.00118474362847 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/512 4/7206 0.00135135556196 ko03010 Ribosome 1/512 129/7206 0.00146243668174 ko00592 alpha-Linolenic acid metabolism 6/512 19/7206 0.00152431803668 ko04022 cGMP-PKG signaling pathway 28/512 216/7206 0.00173711710975 ko04060 Cytokine-cytokine receptor interaction 25/512 191/7206 0.00249281925048 ko03320 PPAR signaling pathway 12/512 69/7206 0.00307125914009 ko00950 Isoquinoline alkaloid biosynthesis 4/512 10/7206 0.00374432966059 ko00982 Drug metabolism - cytochrome P450 8/512 37/7206 0.00377636539603 ko00360 Phenylalanine metabolism 5/512 17/7206 0.00536443253622 ko04960 Aldosterone-regulated sodium reabsorption 8/512 41/7206 0.00727785167316 ko00380 Tryptophan metabolism 9/512 50/7206 0.00782378258869 ko00983 Drug metabolism - other enzymes 8/512 42/7206 0.0084468528175 ko00565 Ether lipid metabolism 8/512 42/7206 0.0084468528175 ko04650 Natural killer cell mediated cytotoxicity 14/512 97/7206 0.00896799308233 ko04921 Oxytocin signaling pathway 25/512 209/7206 0.00896872552809 ko05034 Alcoholism 7/512 238/7206 0.00953122885765 ko04270 Vascular smooth muscle contraction 20/512 154/7206 0.00990148768064 ko04711 Circadian rhythm - fly 4/512 13/7206 0.0107432605728 ko00100 Steroid biosynthesis 5/512 21/7206 0.0139356857627 ko04724 Glutamatergic synapse 19/512 152/7206 0.01528272625 ko00564 Glycerophospholipid metabolism 14/512 99/7206 0.0153982208178 ko04072 Phospholipase D signaling pathway 23/512 197/7206 0.0162336010317 ko05231 Choline metabolism in cancer 17/512 134/7206 0.0167018326596 ko05203 Viral carcinogenesis 10/512 277/7206 0.0168681551651 ko02010 ABC transporters 7/512 39/7206 0.0184425690308 ko05204 Chemical carcinogenesis 8/512 48/7206 0.0186052423722 ko04657 IL-17 signaling pathway 1/512 87/7206 0.0202208558494 ko04111 Cell cycle - yeast 1/512 90/7206 0.0206547129592 ko05224 Breast cancer 5/512 174/7206 0.02414942832 ko04080 Neuroactive ligand-receptor interaction 42/512 423/7206 0.0244863904345 ko05322 Systemic lupus erythematosus 4/512 151/7206 0.0248210349347 ko04971 Gastric acid secretion 13/512 98/7206 0.026663831489 ko00052 Galactose metabolism 6/512 33/7206 0.0267141173874 ko00830 Retinol metabolism 7/512 42/7206 0.0269471639968 ko04720 Long-term potentiation 13/512 99/7206 0.0279302522481 ko01040 Biosynthesis of unsaturated fatty acids 5/512 25/7206 0.0288015035876 ko00590 Arachidonic acid metabolism 8/512 52/7206 0.0289872499952 ko04750 Inflammatory mediator regulation of TRP channels 15/512 122/7206 0.031891884693 ko00500 Starch and sucrose metabolism 6/512 35/7206 0.0347530448029 ko05031 Amphetamine addiction 12/512 91/7206 0.0361514564979 ko04630 Jak-STAT signaling pathway 16/512 132/7206 0.0373607872196 ko05169 Epstein-Barr virus infection 7/512 206/7206 0.0375424011224 ko00330 Arginine and proline metabolism 9/512 61/7206 0.0381194688426 ko05152 Tuberculosis 21/512 187/7206 0.0414859905719 ko04713 Circadian entrainment 16/512 136/7206 0.0416087287967 ko04024 cAMP signaling pathway 29/512 279/7206 0.0420292697588 ko00561 Glycerolipid metabolism 9/512 63/7206 0.0421814330113 ko04726 Serotonergic synapse 16/512 137/7206 0.0429501373353 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/512 5/7206 0.043628228179 ko04672 Intestinal immune network for IgA production 6/512 37/7206 0.0442048011389 ko00270 Cysteine and methionine metabolism 7/512 47/7206 0.0464156643015 ko04745 Phototransduction - fly 6/512 38/7206 0.0494771904945