ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	214/1339	423/7206	9.31485194417e-54
ko04713	Circadian entrainment	85/1339	136/7206	3.80396749338e-30
ko04724	Glutamatergic synapse	90/1339	152/7206	2.666937111e-29
ko05033	Nicotine addiction	48/1339	56/7206	1.23281204773e-27
ko05032	Morphine addiction	70/1339	110/7206	1.09742456052e-25
ko04727	GABAergic synapse	69/1339	110/7206	8.6452526278e-25
ko04725	Cholinergic synapse	82/1339	160/7206	3.90443358674e-21
ko04020	Calcium signaling pathway	111/1339	265/7206	3.03164506402e-19
ko04728	Dopaminergic synapse	87/1339	185/7206	3.4503192336e-19
ko04723	Retrograde endocannabinoid signaling	81/1339	175/7206	2.02351203215e-17
ko04911	Insulin secretion	62/1339	117/7206	3.46661856959e-17
ko04024	cAMP signaling pathway	110/1339	279/7206	1.28228834848e-16
ko04921	Oxytocin signaling pathway	88/1339	209/7206	1.30107906704e-15
ko04742	Taste transduction	39/1339	61/7206	6.05747748123e-15
ko04721	Synaptic vesicle cycle	46/1339	80/7206	7.44054498516e-15
ko04726	Serotonergic synapse	63/1339	137/7206	1.19143687992e-13
ko04261	Adrenergic signaling in cardiomyocytes	82/1339	205/7206	4.06692886946e-13
ko04740	Olfactory transduction	42/1339	80/7206	7.05072194625e-12
ko04022	cGMP-PKG signaling pathway	81/1339	216/7206	3.02869369599e-11
ko03040	Spliceosome	2/1339	145/7206	8.21239462086e-11
ko04970	Salivary secretion	45/1339	95/7206	1.178288286e-10
ko04744	Phototransduction	24/1339	36/7206	2.99313213119e-10
ko04925	Aldosterone synthesis and secretion	47/1339	105/7206	8.62879545144e-10
ko04360	Axon guidance	82/1339	233/7206	9.85441388262e-10
ko05031	Amphetamine addiction	42/1339	91/7206	1.34810293895e-09
ko04971	Gastric acid secretion	44/1339	98/7206	1.61943361928e-09
ko04720	Long-term potentiation	44/1339	99/7206	3.6415500941e-09
ko03013	RNA transport	6/1339	166/7206	7.58067537853e-09
ko05203	Viral carcinogenesis	20/1339	277/7206	6.09862113781e-08
ko05322	Systemic lupus erythematosus	6/1339	151/7206	1.17479892593e-07
ko05168	Herpes simplex infection	10/1339	182/7206	3.34022139517e-07
ko04010	MAPK signaling pathway	96/1339	321/7206	4.76532049508e-07
ko04730	Long-term depression	33/1339	78/7206	1.06407231012e-06
ko05030	Cocaine addiction	31/1339	73/7206	2.14362425528e-06
ko03008	Ribosome biogenesis in eukaryotes	1/1339	79/7206	2.91248446042e-06
ko05164	Influenza A	10/1339	167/7206	4.13647180758e-06
ko04371	Apelin signaling pathway	58/1339	177/7206	4.96667998697e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	26/1339	59/7206	5.51887859897e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	32/1339	79/7206	5.91489426057e-06
ko04972	Pancreatic secretion	40/1339	111/7206	1.13389142241e-05
ko04621	NOD-like receptor signaling pathway	10/1339	157/7206	1.59586398974e-05
ko04540	Gap junction	44/1339	128/7206	1.66904230511e-05
ko04120	Ubiquitin mediated proteolysis	8/1339	138/7206	2.00896383152e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1339	74/7206	2.99121324725e-05
ko04976	Bile secretion	31/1339	80/7206	3.01545083734e-05
ko04141	Protein processing in endoplasmic reticulum	14/1339	184/7206	3.05583142191e-05
ko04514	Cell adhesion molecules (CAMs)	44/1339	130/7206	3.07743025879e-05
ko04060	Cytokine-cytokine receptor interaction	15/1339	191/7206	4.14109857017e-05
ko04745	Phototransduction - fly	18/1339	38/7206	4.75030064006e-05
ko05169	Epstein-Barr virus infection	18/1339	206/7206	8.46290135844e-05
ko04260	Cardiac muscle contraction	34/1339	98/7206	0.000122125658277
ko04014	Ras signaling pathway	77/1339	279/7206	0.000154991430912
ko04072	Phospholipase D signaling pathway	58/1339	197/7206	0.000179465430684
ko05414	Dilated cardiomyopathy	37/1339	112/7206	0.000205777773717
ko04270	Vascular smooth muscle contraction	47/1339	154/7206	0.000319529455701
ko04750	Inflammatory mediator regulation of TRP channels	39/1339	122/7206	0.000359273731834
ko04924	Renin secretion	30/1339	86/7206	0.000372654485856
ko04070	Phosphatidylinositol signaling system	36/1339	112/7206	0.000517499239622
ko04110	Cell cycle	12/1339	145/7206	0.000737312049726
ko04146	Peroxisome	5/1339	89/7206	0.000815939626114
ko04064	NF-kappa B signaling pathway	6/1339	96/7206	0.00082649182661
ko05162	Measles	9/1339	120/7206	0.000828623539564
ko04612	Antigen processing and presentation	4/1339	77/7206	0.00102463333331
ko00240	Pyrimidine metabolism	8/1339	110/7206	0.00117245936472
ko04930	Type II diabetes mellitus	20/1339	54/7206	0.00125307498467
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1339	182/7206	0.00139220799607
ko00071	Fatty acid degradation	1/1339	45/7206	0.00170560943825
ko03420	Nucleotide excision repair	1/1339	46/7206	0.00176063699395
ko04217	Necroptosis	18/1339	178/7206	0.00236252017947
ko05410	Hypertrophic cardiomyopathy (HCM)	31/1339	100/7206	0.00260847399609
ko03022	Basal transcription factors	1/1339	44/7206	0.00271389361523
ko04622	RIG-I-like receptor signaling pathway	3/1339	62/7206	0.00276797605115
ko04916	Melanogenesis	41/1339	142/7206	0.00300976321344
ko04915	Estrogen signaling pathway	38/1339	131/7206	0.00308217380498
ko04657	IL-17 signaling pathway	6/1339	87/7206	0.00322039814359
ko00590	Arachidonic acid metabolism	2/1339	52/7206	0.00350490875627
ko00330	Arginine and proline metabolism	3/1339	61/7206	0.00419650839896
ko03018	RNA degradation	6/1339	84/7206	0.00444132768667
ko04711	Circadian rhythm - fly	7/1339	13/7206	0.00453130442021
ko00380	Tryptophan metabolism	2/1339	50/7206	0.00523500011634
ko05131	Shigellosis	6/1339	82/7206	0.00618014663423
ko04923	Regulation of lipolysis in adipocytes	24/1339	77/7206	0.00736986432846
ko04658	Th1 and Th2 cell differentiation	8/1339	96/7206	0.00772223925157
ko04918	Thyroid hormone synthesis	26/1339	86/7206	0.00774441958493
ko05133	Pertussis	7/1339	87/7206	0.008130528943
ko00480	Glutathione metabolism	3/1339	55/7206	0.00836933486789
ko05205	Proteoglycans in cancer	34/1339	271/7206	0.00844995463647
ko04610	Complement and coagulation cascades	6/1339	79/7206	0.00850443844209
ko04710	Circadian rhythm	15/1339	43/7206	0.00975105070196
ko04142	Lysosome	16/1339	151/7206	0.01070064769
ko04216	Ferroptosis	2/1339	44/7206	0.0110355704543
ko04015	Rap1 signaling pathway	68/1339	278/7206	0.0118470849409
ko04512	ECM-receptor interaction	24/1339	79/7206	0.0123866162111
ko04113	Meiosis - yeast	5/1339	70/7206	0.012424668018
ko00280	Valine, leucine and isoleucine degradation	3/1339	54/7206	0.0124735885852
ko04912	GnRH signaling pathway	34/1339	122/7206	0.0130358879033
ko04620	Toll-like receptor signaling pathway	9/1339	100/7206	0.0131145319316
ko00860	Porphyrin and chlorophyll metabolism	1/1339	34/7206	0.0136413275284
ko04964	Proximal tubule bicarbonate reclamation	11/1339	29/7206	0.0139205246578
ko04115	p53 signaling pathway	6/1339	74/7206	0.0160523035881
ko05140	Leishmaniasis	6/1339	75/7206	0.0161174969345
ko04630	Jak-STAT signaling pathway	14/1339	132/7206	0.0171435242921
ko04966	Collecting duct acid secretion	10/1339	26/7206	0.0187170761132
ko05012	Parkinson's disease	18/1339	155/7206	0.0216465151064
ko01200	Carbon metabolism	14/1339	128/7206	0.0218952881208
ko00310	Lysine degradation	6/1339	73/7206	0.0221280091533
ko05110	Vibrio cholerae infection	19/1339	63/7206	0.0225168774206
ko04640	Hematopoietic cell lineage	5/1339	64/7206	0.0232618504332
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1339	40/7206	0.0236148435684
ko04974	Protein digestion and absorption	27/1339	96/7206	0.0236409310366
ko05321	Inflammatory bowel disease (IBD)	4/1339	56/7206	0.0242551425546
ko00140	Steroid hormone biosynthesis	2/1339	41/7206	0.0243024207095
ko00260	Glycine, serine and threonine metabolism	3/1339	48/7206	0.0245427065925
ko05161	Hepatitis B	21/1339	173/7206	0.0289785970089
ko03320	PPAR signaling pathway	6/1339	69/7206	0.0297821930827
ko05320	Autoimmune thyroid disease	1/1339	29/7206	0.0308316407394
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1339	14/7206	0.0314134063964
ko05016	Huntington's disease	28/1339	215/7206	0.0325635867236
ko04140	Autophagy - animal	20/1339	164/7206	0.0327627672303
ko00982	Drug metabolism - cytochrome P450	2/1339	37/7206	0.0343218893497
ko05132	Salmonella infection	10/1339	98/7206	0.0353186789829
ko05215	Prostate cancer	12/1339	111/7206	0.035783008958
ko04978	Mineral absorption	13/1339	40/7206	0.0381925729785
ko04922	Glucagon signaling pathway	33/1339	128/7206	0.0389703830768
ko04210	Apoptosis	23/1339	180/7206	0.0416238168299
ko04960	Aldosterone-regulated sodium reabsorption	13/1339	41/7206	0.0416985150141
ko04138	Autophagy - yeast	8/1339	81/7206	0.0437186601321
ko01212	Fatty acid metabolism	5/1339	60/7206	0.0439860349421
ko04973	Carbohydrate digestion and absorption	13/1339	42/7206	0.0463345943967
ko05418	Fluid shear stress and atherosclerosis	22/1339	173/7206	0.0474076777333
ko00020	Citrate cycle (TCA cycle)	2/1339	35/7206	0.0496154649392
ko00500	Starch and sucrose metabolism	2/1339	35/7206	0.0496154649392