ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	179/1046	423/7206	3.4644438228e-47
ko04724	Glutamatergic synapse	82/1046	152/7206	1.0875249808e-30
ko05033	Nicotine addiction	44/1046	56/7206	5.75015100993e-27
ko05032	Morphine addiction	63/1046	110/7206	9.97549167514e-26
ko04721	Synaptic vesicle cycle	51/1046	80/7206	4.58463848694e-24
ko04713	Circadian entrainment	68/1046	136/7206	4.47441828107e-23
ko04727	GABAergic synapse	59/1046	110/7206	3.59420631596e-22
ko04728	Dopaminergic synapse	80/1046	185/7206	8.36342845325e-22
ko04725	Cholinergic synapse	70/1046	160/7206	1.52294965313e-19
ko04723	Retrograde endocannabinoid signaling	72/1046	175/7206	3.03401885348e-18
ko04020	Calcium signaling pathway	90/1046	265/7206	4.18139588373e-16
ko04024	cAMP signaling pathway	93/1046	279/7206	5.34745726814e-16
ko04742	Taste transduction	35/1046	61/7206	7.43687563398e-15
ko04911	Insulin secretion	50/1046	117/7206	8.39120227137e-14
ko04726	Serotonergic synapse	55/1046	137/7206	1.13400438871e-13
ko04921	Oxytocin signaling pathway	72/1046	209/7206	3.14505127222e-13
ko04261	Adrenergic signaling in cardiomyocytes	67/1046	205/7206	2.49058406741e-11
ko04970	Salivary secretion	40/1046	95/7206	4.68097600469e-11
ko05031	Amphetamine addiction	38/1046	91/7206	1.92778679206e-10
ko04720	Long-term potentiation	39/1046	99/7206	8.78557414115e-10
ko03040	Spliceosome	1/1046	145/7206	5.82307863189e-09
ko04744	Phototransduction	20/1046	36/7206	1.04486522685e-08
ko05203	Viral carcinogenesis	12/1046	277/7206	4.27917113133e-08
ko05168	Herpes simplex infection	5/1046	182/7206	1.64181946111e-07
ko04925	Aldosterone synthesis and secretion	36/1046	105/7206	3.21187130891e-07
ko04966	Collecting duct acid secretion	15/1046	26/7206	3.89380120557e-07
ko04971	Gastric acid secretion	34/1046	98/7206	5.93627058787e-07
ko04360	Axon guidance	62/1046	233/7206	9.73798053269e-07
ko05164	Influenza A	5/1046	167/7206	1.07327195679e-06
ko04060	Cytokine-cytokine receptor interaction	7/1046	191/7206	1.12222535395e-06
ko05322	Systemic lupus erythematosus	4/1046	151/7206	1.75399123508e-06
ko04514	Cell adhesion molecules (CAMs)	40/1046	130/7206	1.75637785083e-06
ko04120	Ubiquitin mediated proteolysis	3/1046	138/7206	1.90046061e-06
ko04010	MAPK signaling pathway	77/1046	321/7206	4.53660941106e-06
ko05030	Cocaine addiction	26/1046	73/7206	5.37162759025e-06
ko03013	RNA transport	6/1046	166/7206	5.79027976823e-06
ko04022	cGMP-PKG signaling pathway	56/1046	216/7206	7.78520146408e-06
ko04740	Olfactory transduction	27/1046	80/7206	1.46079643962e-05
ko04621	NOD-like receptor signaling pathway	6/1046	157/7206	1.6993303938e-05
ko04540	Gap junction	37/1046	128/7206	2.07121408192e-05
ko04972	Pancreatic secretion	33/1046	111/7206	3.11046308006e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1046	74/7206	3.18401079237e-05
ko04745	Phototransduction - fly	16/1046	38/7206	3.29133584071e-05
ko05110	Vibrio cholerae infection	22/1046	63/7206	4.0040034147e-05
ko04141	Protein processing in endoplasmic reticulum	9/1046	184/7206	4.44339873572e-05
ko04730	Long-term depression	25/1046	78/7206	6.79384352281e-05
ko04924	Renin secretion	27/1046	86/7206	6.92864126173e-05
ko04070	Phosphatidylinositol signaling system	32/1046	112/7206	0.00010973367481
ko05169	Epstein-Barr virus infection	12/1046	206/7206	0.000116917382949
ko04260	Cardiac muscle contraction	29/1046	98/7206	0.000117724975857
ko04612	Antigen processing and presentation	1/1046	77/7206	0.000125431732237
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1046	79/7206	0.000136602674775
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1046	59/7206	0.000234750139172
ko04750	Inflammatory mediator regulation of TRP channels	33/1046	122/7206	0.000241448326443
ko04014	Ras signaling pathway	63/1046	279/7206	0.000245191817957
ko04110	Cell cycle	7/1046	145/7206	0.000296685494831
ko04976	Bile secretion	24/1046	80/7206	0.000326055756476
ko04626	Plant-pathogen interaction	9/1046	18/7206	0.000389990579702
ko05414	Dilated cardiomyopathy	30/1046	112/7206	0.000604075757298
ko03008	Ribosome biogenesis in eukaryotes	2/1046	79/7206	0.000632718623033
ko05161	Hepatitis B	11/1046	173/7206	0.000993917762561
ko05166	HTLV-I infection	24/1046	292/7206	0.0012067048561
ko05205	Proteoglycans in cancer	22/1046	271/7206	0.00149135797033
ko05162	Measles	6/1046	120/7206	0.00150157045795
ko04214	Apoptosis - fly	2/1046	72/7206	0.0020269602085
ko04072	Phospholipase D signaling pathway	44/1046	197/7206	0.00277120220022
ko04371	Apelin signaling pathway	40/1046	177/7206	0.00335329221848
ko04630	Jak-STAT signaling pathway	8/1046	132/7206	0.00378442718979
ko04915	Estrogen signaling pathway	31/1046	131/7206	0.00539916461353
ko04964	Proximal tubule bicarbonate reclamation	10/1046	29/7206	0.00576781448534
ko04640	Hematopoietic cell lineage	2/1046	64/7206	0.00640581386578
ko05140	Leishmaniasis	3/1046	75/7206	0.00732670743493
ko04064	NF-kappa B signaling pathway	5/1046	96/7206	0.00781378442728
ko05215	Prostate cancer	7/1046	111/7206	0.00965908074151
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1046	14/7206	0.00975333940832
ko03420	Nucleotide excision repair	1/1046	46/7206	0.0107169446583
ko04916	Melanogenesis	32/1046	142/7206	0.010849967429
ko00260	Glycine, serine and threonine metabolism	1/1046	48/7206	0.0114358243623
ko05219	Bladder cancer	1/1046	48/7206	0.0114358243623
ko05321	Inflammatory bowel disease (IBD)	2/1046	56/7206	0.0130176142731
ko04146	Peroxisome	5/1046	89/7206	0.0144053468391
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1046	92/7206	0.0160332034592
ko03022	Basal transcription factors	1/1046	44/7206	0.016156787263
ko00071	Fatty acid degradation	1/1046	45/7206	0.0168159892864
ko04217	Necroptosis	15/1046	178/7206	0.0174769104762
ko00280	Valine, leucine and isoleucine degradation	2/1046	54/7206	0.0187882971586
ko00480	Glutathione metabolism	2/1046	55/7206	0.0191503256837
ko05220	Chronic myeloid leukemia	5/1046	85/7206	0.0195069543784
ko04657	IL-17 signaling pathway	5/1046	87/7206	0.020161335004
ko01524	Platinum drug resistance	4/1046	76/7206	0.0204134036163
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1046	100/7206	0.0213010436488
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1046	182/7206	0.0248844307903
ko04668	TNF signaling pathway	9/1046	120/7206	0.0257909866026
ko05131	Shigellosis	5/1046	82/7206	0.0265943484468
ko03018	RNA degradation	5/1046	84/7206	0.0274409561158
ko00590	Arachidonic acid metabolism	2/1046	52/7206	0.027455886844
ko00330	Arginine and proline metabolism	3/1046	61/7206	0.0280048489119
ko00310	Lysine degradation	4/1046	73/7206	0.0281772525337
ko05418	Fluid shear stress and atherosclerosis	15/1046	173/7206	0.0281959707168
ko04330	Notch signaling pathway	3/1046	62/7206	0.0282109157102
ko04622	RIG-I-like receptor signaling pathway	3/1046	62/7206	0.0282109157102
ko00240	Pyrimidine metabolism	8/1046	110/7206	0.0283836104588
ko04930	Type II diabetes mellitus	14/1046	54/7206	0.0299017496246
ko04923	Regulation of lipolysis in adipocytes	18/1046	77/7206	0.0336159721646
ko04912	GnRH signaling pathway	26/1046	122/7206	0.0376088738338
ko04114	Oocyte meiosis	29/1046	139/7206	0.0381894596268
ko05206	MicroRNAs in cancer	16/1046	177/7206	0.0393222122154
ko05145	Toxoplasmosis	10/1046	126/7206	0.0399220393386
ko00380	Tryptophan metabolism	2/1046	50/7206	0.040494118274
ko04658	Th1 and Th2 cell differentiation	7/1046	96/7206	0.0409923878495
ko05133	Pertussis	6/1046	87/7206	0.0451660291238
ko04350	TGF-beta signaling pathway	8/1046	103/7206	0.0486415464133
ko04270	Vascular smooth muscle contraction	31/1046	154/7206	0.0494557686393