ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	188/1124	423/7206	1.48187016387e-48
ko04724	Glutamatergic synapse	86/1124	152/7206	7.85200138491e-32
ko05033	Nicotine addiction	47/1124	56/7206	9.38708634526e-30
ko04721	Synaptic vesicle cycle	54/1124	80/7206	1.09779143107e-25
ko05032	Morphine addiction	64/1124	110/7206	7.55195774761e-25
ko04713	Circadian entrainment	71/1124	136/7206	1.37854478786e-23
ko04727	GABAergic synapse	61/1124	110/7206	3.18782451261e-22
ko04728	Dopaminergic synapse	80/1124	185/7206	8.74031984987e-20
ko04725	Cholinergic synapse	72/1124	160/7206	4.25802078949e-19
ko04723	Retrograde endocannabinoid signaling	72/1124	175/7206	1.75820899494e-16
ko04024	cAMP signaling pathway	98/1124	279/7206	2.26939967524e-16
ko04742	Taste transduction	37/1124	61/7206	1.07806876735e-15
ko04020	Calcium signaling pathway	92/1124	265/7206	4.35724310788e-15
ko04921	Oxytocin signaling pathway	77/1124	209/7206	3.09081248229e-14
ko04726	Serotonergic synapse	58/1124	137/7206	3.69959831652e-14
ko04911	Insulin secretion	50/1124	117/7206	1.44537640405e-12
ko04261	Adrenergic signaling in cardiomyocytes	70/1124	205/7206	2.69732421745e-11
ko05031	Amphetamine addiction	40/1124	91/7206	9.02539085509e-11
ko04720	Long-term potentiation	42/1124	99/7206	1.21511145749e-10
ko04970	Salivary secretion	40/1124	95/7206	4.44721753998e-10
ko04744	Phototransduction	22/1124	36/7206	6.1337454619e-10
ko03040	Spliceosome	1/1124	145/7206	8.38362935935e-10
ko04740	Olfactory transduction	34/1124	80/7206	6.82992979063e-09
ko05168	Herpes simplex infection	5/1124	182/7206	1.98305180842e-08
ko04360	Axon guidance	68/1124	233/7206	1.00706195106e-07
ko04966	Collecting duct acid secretion	16/1124	26/7206	1.2477547406e-07
ko05203	Viral carcinogenesis	15/1124	277/7206	1.75213522507e-07
ko04971	Gastric acid secretion	36/1124	98/7206	2.77440824439e-07
ko04060	Cytokine-cytokine receptor interaction	8/1124	191/7206	8.03530051866e-07
ko04540	Gap junction	42/1124	128/7206	9.13938188621e-07
ko05164	Influenza A	6/1124	167/7206	1.23980077949e-06
ko05030	Cocaine addiction	28/1124	73/7206	1.82498598565e-06
ko04925	Aldosterone synthesis and secretion	36/1124	105/7206	1.88165208337e-06
ko04120	Ubiquitin mediated proteolysis	4/1124	138/7206	2.25946674891e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1124	74/7206	2.50571615982e-06
ko04260	Cardiac muscle contraction	34/1124	98/7206	3.26052885189e-06
ko04022	cGMP-PKG signaling pathway	60/1124	216/7206	3.59312619827e-06
ko03013	RNA transport	7/1124	166/7206	6.22108329248e-06
ko04924	Renin secretion	30/1124	86/7206	8.11050842439e-06
ko05322	Systemic lupus erythematosus	6/1124	151/7206	1.12521013648e-05
ko04621	NOD-like receptor signaling pathway	7/1124	157/7206	1.75272171575e-05
ko04745	Phototransduction - fly	17/1124	38/7206	1.86432434328e-05
ko04514	Cell adhesion molecules (CAMs)	39/1124	130/7206	2.58701781157e-05
ko04730	Long-term depression	27/1124	78/7206	2.71605733073e-05
ko04141	Protein processing in endoplasmic reticulum	10/1124	184/7206	3.01171603836e-05
ko04610	Complement and coagulation cascades	1/1124	79/7206	3.30556442919e-05
ko04010	MAPK signaling pathway	78/1124	321/7206	3.72913600094e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1124	59/7206	3.86495670246e-05
ko05169	Epstein-Barr virus infection	13/1124	206/7206	5.61455986448e-05
ko05110	Vibrio cholerae infection	23/1124	63/7206	6.01623355755e-05
ko04110	Cell cycle	7/1124	145/7206	6.99093079137e-05
ko04626	Plant-pathogen interaction	10/1124	18/7206	0.000107812555229
ko05162	Measles	5/1124	120/7206	0.000114739283897
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1124	79/7206	0.000117291847798
ko03008	Ribosome biogenesis in eukaryotes	2/1124	79/7206	0.000268687516392
ko04972	Pancreatic secretion	32/1124	111/7206	0.000320713360411
ko04014	Ras signaling pathway	66/1124	279/7206	0.000373300057778
ko04612	Antigen processing and presentation	2/1124	77/7206	0.00039771042108
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1124	14/7206	0.000425207190463
ko04976	Bile secretion	25/1124	80/7206	0.000471779905072
ko05414	Dilated cardiomyopathy	32/1124	112/7206	0.00051706902625
ko05140	Leishmaniasis	2/1124	75/7206	0.000595779983191
ko05205	Proteoglycans in cancer	23/1124	271/7206	0.000600322626228
ko04371	Apelin signaling pathway	45/1124	177/7206	0.000698935959688
ko04214	Apoptosis - fly	2/1124	72/7206	0.000871561608004
ko04064	NF-kappa B signaling pathway	4/1124	96/7206	0.00091152981689
ko05166	HTLV-I infection	26/1124	292/7206	0.000928007527957
ko04750	Inflammatory mediator regulation of TRP channels	33/1124	122/7206	0.000971459952125
ko05161	Hepatitis B	13/1124	173/7206	0.00195730720088
ko04915	Estrogen signaling pathway	34/1124	131/7206	0.00213359272011
ko00480	Glutathione metabolism	1/1124	55/7206	0.00215022223798
ko04964	Proximal tubule bicarbonate reclamation	11/1124	29/7206	0.00289961631245
ko00590	Arachidonic acid metabolism	1/1124	52/7206	0.00316087848972
ko00310	Lysine degradation	3/1124	73/7206	0.00325127843697
ko04070	Phosphatidylinositol signaling system	29/1124	112/7206	0.00530307473741
ko04922	Glucagon signaling pathway	32/1124	128/7206	0.00633476559903
ko00071	Fatty acid degradation	1/1124	45/7206	0.00686587930192
ko03420	Nucleotide excision repair	1/1124	46/7206	0.00691126300362
ko04657	IL-17 signaling pathway	5/1124	87/7206	0.00716574483732
ko04146	Peroxisome	5/1124	89/7206	0.00736541816278
ko04630	Jak-STAT signaling pathway	10/1124	132/7206	0.00755745939333
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1124	100/7206	0.00762401385626
ko05321	Inflammatory bowel disease (IBD)	2/1124	56/7206	0.00863234914114
ko03018	RNA degradation	5/1124	84/7206	0.0099304746058
ko01524	Platinum drug resistance	4/1124	76/7206	0.0100508952726
ko03022	Basal transcription factors	1/1124	44/7206	0.0105488463491
ko04668	TNF signaling pathway	9/1124	120/7206	0.0108449552154
ko00240	Pyrimidine metabolism	8/1124	110/7206	0.011696034145
ko04072	Phospholipase D signaling pathway	44/1124	197/7206	0.0123623175625
ko00280	Valine, leucine and isoleucine degradation	2/1124	54/7206	0.0127728530755
ko05145	Toxoplasmosis	10/1124	126/7206	0.0131809408691
ko04330	Notch signaling pathway	3/1124	62/7206	0.0135548420586
ko04622	RIG-I-like receptor signaling pathway	3/1124	62/7206	0.0135548420586
ko05131	Shigellosis	5/1124	82/7206	0.0136909782929
ko04640	Hematopoietic cell lineage	3/1124	64/7206	0.0139267558797
ko04923	Regulation of lipolysis in adipocytes	20/1124	77/7206	0.0169838285319
ko00380	Tryptophan metabolism	2/1124	50/7206	0.0180496182815
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1124	92/7206	0.0194673286732
ko04217	Necroptosis	17/1124	178/7206	0.0213999936888
ko04658	Th1 and Th2 cell differentiation	7/1124	96/7206	0.0226008274828
ko00630	Glyoxylate and dicarboxylate metabolism	1/1124	38/7206	0.0229269766334
ko03410	Base excision repair	1/1124	38/7206	0.0229269766334
ko05215	Prostate cancer	9/1124	111/7206	0.0249393812085
ko04916	Melanogenesis	32/1124	142/7206	0.0261103475372
ko00260	Glycine, serine and threonine metabolism	2/1124	48/7206	0.0262722002269
ko04912	GnRH signaling pathway	28/1124	122/7206	0.0314947148007
ko05212	Pancreatic cancer	6/1124	83/7206	0.0325813029425
ko05418	Fluid shear stress and atherosclerosis	17/1124	173/7206	0.0335871043515
ko00500	Starch and sucrose metabolism	1/1124	35/7206	0.0338930709148
ko04115	p53 signaling pathway	5/1124	74/7206	0.0351174522749
ko04722	Neurotrophin signaling pathway	35/1124	160/7206	0.0354582593309
ko05146	Amoebiasis	8/1124	99/7206	0.0361162115579
ko05034	Alcoholism	49/1124	238/7206	0.0363063179655
ko04620	Toll-like receptor signaling pathway	8/1124	100/7206	0.0363174471129
ko04145	Phagosome	35/1124	162/7206	0.037351601116
ko05144	Malaria	2/1124	45/7206	0.0376208725256
ko05222	Small cell lung cancer	7/1124	89/7206	0.0398511525855
ko04015	Rap1 signaling pathway	56/1124	278/7206	0.0425308534913
ko05010	Alzheimer's disease	42/1124	202/7206	0.048441356511