ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 71/382 145/7206 3.99117898633e-53 ko03013 RNA transport 57/382 166/7206 3.04096742951e-32 ko03008 Ribosome biogenesis in eukaryotes 33/382 79/7206 4.18726715067e-22 ko03015 mRNA surveillance pathway 25/382 93/7206 6.42233473113e-12 ko03020 RNA polymerase 14/382 29/7206 4.10237191188e-11 ko00240 Pyrimidine metabolism 26/382 110/7206 5.767652697e-11 ko03030 DNA replication 15/382 38/7206 2.82590637446e-10 ko04144 Endocytosis 1/382 342/7206 1.82065173714e-07 ko03430 Mismatch repair 9/382 22/7206 8.08963898006e-07 ko04113 Meiosis - yeast 15/382 70/7206 2.76024976585e-06 ko03420 Nucleotide excision repair 12/382 46/7206 3.12451936652e-06 ko03018 RNA degradation 16/382 84/7206 6.57091134171e-06 ko04111 Cell cycle - yeast 16/382 90/7206 1.64788624404e-05 ko03410 Base excision repair 10/382 38/7206 1.93469497853e-05 ko04110 Cell cycle 21/382 145/7206 2.25484966264e-05 ko03440 Homologous recombination 10/382 41/7206 3.97685856235e-05 ko00230 Purine metabolism 24/382 194/7206 0.000105676123246 ko04151 PI3K-Akt signaling pathway 6/382 390/7206 0.000165378212866 ko04015 Rap1 signaling pathway 3/382 278/7206 0.000310189288869 ko04024 cAMP signaling pathway 3/382 279/7206 0.000312409155129 ko05200 Pathways in cancer 10/382 492/7206 0.000340283305141 ko03022 Basal transcription factors 9/382 44/7206 0.000407399925875 ko04072 Phospholipase D signaling pathway 1/382 197/7206 0.000511932021357 ko04022 cGMP-PKG signaling pathway 2/382 216/7206 0.00102364355357 ko04217 Necroptosis 1/382 178/7206 0.00105524046787 ko03460 Fanconi anemia pathway 9/382 51/7206 0.00125875482228 ko04014 Ras signaling pathway 4/382 279/7206 0.00146435933533 ko05010 Alzheimer's disease 2/382 202/7206 0.00211755671532 ko04621 NOD-like receptor signaling pathway 1/382 157/7206 0.00331590072758 ko04725 Cholinergic synapse 1/382 160/7206 0.00344601032053 ko04670 Leukocyte transendothelial migration 1/382 151/7206 0.00490454070514 ko04371 Apelin signaling pathway 2/382 177/7206 0.00611900167872 ko04921 Oxytocin signaling pathway 3/382 209/7206 0.0069963348495 ko03050 Proteasome 8/382 54/7206 0.00706957134191 ko04010 MAPK signaling pathway 7/382 321/7206 0.00711848084736 ko04810 Regulation of actin cytoskeleton 5/382 264/7206 0.00746125917096 ko00970 Aminoacyl-tRNA biosynthesis 7/382 44/7206 0.00779063598341 ko04062 Chemokine signaling pathway 3/382 201/7206 0.00974425275277 ko04530 Tight junction 4/382 228/7206 0.0101070073881 ko04261 Adrenergic signaling in cardiomyocytes 3/382 205/7206 0.0101333315175 ko04933 AGE-RAGE signaling pathway in diabetic complications 1/382 135/7206 0.0102409047886 ko05169 Epstein-Barr virus infection 20/382 206/7206 0.0102835264169 ko04726 Serotonergic synapse 1/382 137/7206 0.0104961605526 ko04139 Mitophagy - yeast 6/382 37/7206 0.012268563334 ko04071 Sphingolipid signaling pathway 2/382 162/7206 0.0123095847208 ko05164 Influenza A 2/382 167/7206 0.0127604247311 ko05167 Kaposi's sarcoma-associated herpesvirus infection 3/382 191/7206 0.0134463158758 ko00190 Oxidative phosphorylation 1/382 127/7206 0.0147795787745 ko04540 Gap junction 1/382 128/7206 0.0149177406461 ko05142 Chagas disease (American trypanosomiasis) 1/382 130/7206 0.0153275037358 ko04915 Estrogen signaling pathway 1/382 131/7206 0.0155997087474 ko04270 Vascular smooth muscle contraction 2/382 154/7206 0.017380002635 ko04510 Focal adhesion 5/382 240/7206 0.0185086376985 ko04728 Dopaminergic synapse 3/382 185/7206 0.0187305305249 ko05152 Tuberculosis 3/382 187/7206 0.0189806626373 ko04623 Cytosolic DNA-sensing pathway 6/382 41/7206 0.0198789071423 ko04360 Axon guidance 5/382 233/7206 0.0249030679745 ko05168 Herpes simplex infection 17/382 182/7206 0.0269968064332 ko04972 Pancreatic secretion 1/382 111/7206 0.0306722385813 ko03060 Protein export 4/382 23/7206 0.0309126553302 ko04916 Melanogenesis 2/382 142/7206 0.0348816556392 ko04068 FoxO signaling pathway 3/382 167/7206 0.0353503664007 ko05418 Fluid shear stress and atherosclerosis 3/382 173/7206 0.0365775328707 ko05205 Proteoglycans in cancer 7/382 271/7206 0.0379336707427 ko03450 Non-homologous end-joining 3/382 15/7206 0.041806987872 ko04925 Aldosterone synthesis and secretion 1/382 105/7206 0.0446819755655 ko05202 Transcriptional misregulation in cancer 4/382 188/7206 0.0468814841081 ko04152 AMPK signaling pathway 3/382 161/7206 0.0486126233295 ko05231 Choline metabolism in cancer 2/382 134/7206 0.0486795924341 ko04611 Platelet activation 3/382 163/7206 0.0491359600865 ko04712 Circadian rhythm - plant 2/382 7/7206 0.0493007256089