ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	95/841	145/7206	1.85456501937e-54
ko03013	RNA transport	80/841	166/7206	2.53217481997e-32
ko04110	Cell cycle	69/841	145/7206	1.53159503128e-27
ko03008	Ribosome biogenesis in eukaryotes	46/841	79/7206	1.68366745507e-23
ko04080	Neuroactive ligand-receptor interaction	1/841	423/7206	2.71571063408e-22
ko04111	Cell cycle - yeast	47/841	90/7206	3.00414352293e-21
ko03460	Fanconi anemia pathway	34/841	51/7206	2.16902982025e-20
ko03440	Homologous recombination	30/841	41/7206	5.73151931929e-20
ko05322	Systemic lupus erythematosus	59/841	151/7206	1.9348931908e-18
ko03030	DNA replication	27/841	38/7206	1.50329881154e-17
ko03420	Nucleotide excision repair	27/841	46/7206	2.05619954405e-14
ko03018	RNA degradation	37/841	84/7206	6.02925381822e-14
ko00240	Pyrimidine metabolism	43/841	110/7206	9.15650420291e-14
ko04113	Meiosis - yeast	33/841	70/7206	1.28761448139e-13
ko04020	Calcium signaling pathway	1/841	265/7206	1.48596183995e-13
ko03020	RNA polymerase	20/841	29/7206	6.38689599028e-13
ko03015	mRNA surveillance pathway	37/841	93/7206	2.69843752806e-12
ko04144	Endocytosis	7/841	342/7206	3.32840153714e-11
ko03430	Mismatch repair	16/841	22/7206	3.92437678506e-11
ko05034	Alcoholism	63/841	238/7206	1.79565419093e-10
ko03022	Basal transcription factors	21/841	44/7206	2.92405189614e-09
ko05010	Alzheimer's disease	2/841	202/7206	5.55795438801e-09
ko04060	Cytokine-cytokine receptor interaction	2/841	191/7206	2.99484780855e-08
ko03410	Base excision repair	18/841	38/7206	4.66223343387e-08
ko05203	Viral carcinogenesis	63/841	277/7206	9.64801876125e-08
ko05012	Parkinson's disease	1/841	155/7206	1.61978360963e-07
ko04151	PI3K-Akt signaling pathway	17/841	390/7206	3.72872692969e-07
ko04024	cAMP signaling pathway	9/841	279/7206	5.01340912926e-07
ko04723	Retrograde endocannabinoid signaling	3/841	175/7206	1.12332906964e-06
ko04724	Glutamatergic synapse	2/841	152/7206	2.32540490352e-06
ko04932	Non-alcoholic fatty liver disease (NAFLD)	4/841	182/7206	3.40259708796e-06
ko00190	Oxidative phosphorylation	1/841	127/7206	4.1835182074e-06
ko04010	MAPK signaling pathway	14/841	321/7206	4.65837289463e-06
ko04921	Oxytocin signaling pathway	6/841	209/7206	5.34744851394e-06
ko04261	Adrenergic signaling in cardiomyocytes	6/841	205/7206	7.62965375114e-06
ko04022	cGMP-PKG signaling pathway	7/841	216/7206	1.25040477658e-05
ko04911	Insulin secretion	1/841	117/7206	1.42560537175e-05
ko04713	Circadian entrainment	2/841	136/7206	1.74261564375e-05
ko05414	Dilated cardiomyopathy	1/841	112/7206	2.08679526716e-05
ko04972	Pancreatic secretion	1/841	111/7206	3.3141945151e-05
ko04621	NOD-like receptor signaling pathway	4/841	157/7206	4.491678106e-05
ko04725	Cholinergic synapse	4/841	160/7206	4.76123819155e-05
ko04015	Rap1 signaling pathway	13/841	278/7206	5.57581070245e-05
ko04510	Focal adhesion	10/841	240/7206	5.62958475857e-05
ko00230	Purine metabolism	42/841	194/7206	5.69447138632e-05
ko05169	Epstein-Barr virus infection	44/841	206/7206	5.75222237002e-05
ko04270	Vascular smooth muscle contraction	4/841	154/7206	6.45879356507e-05
ko04072	Phospholipase D signaling pathway	7/841	197/7206	6.81013112984e-05
ko04668	TNF signaling pathway	2/841	120/7206	7.69172075833e-05
ko04810	Regulation of actin cytoskeleton	12/841	264/7206	7.84316850277e-05
ko04971	Gastric acid secretion	1/841	98/7206	0.000104662859682
ko05146	Amoebiasis	1/841	99/7206	0.000104948908402
ko04380	Osteoclast differentiation	3/841	134/7206	0.000106768115853
ko05410	Hypertrophic cardiomyopathy (HCM)	1/841	100/7206	0.000107470357757
ko04514	Cell adhesion molecules (CAMs)	3/841	130/7206	0.000153768331125
ko04014	Ras signaling pathway	14/841	279/7206	0.000180796671517
ko04727	GABAergic synapse	2/841	110/7206	0.000244638773963
ko05032	Morphine addiction	2/841	110/7206	0.000244638773963
ko04120	Ubiquitin mediated proteolysis	31/841	138/7206	0.000250867056216
ko04728	Dopaminergic synapse	7/841	185/7206	0.000265504002744
ko04914	Progesterone-mediated oocyte maturation	25/841	104/7206	0.000319916264184
ko04218	Cellular senescence	37/841	177/7206	0.000327727092375
ko04146	Peroxisome	1/841	89/7206	0.00035010915795
ko04726	Serotonergic synapse	4/841	137/7206	0.000388313640263
ko04145	Phagosome	6/841	162/7206	0.000469439411425
ko04062	Chemokine signaling pathway	9/841	201/7206	0.000501109763825
ko04924	Renin secretion	1/841	86/7206	0.000526757728561
ko05168	Herpes simplex infection	37/841	182/7206	0.000613550118849
ko04114	Oocyte meiosis	30/841	139/7206	0.000719111571144
ko04620	Toll-like receptor signaling pathway	2/841	100/7206	0.000770955520486
ko03450	Non-homologous end-joining	7/841	15/7206	0.000793771231362
ko04530	Tight junction	12/841	228/7206	0.00109642650175
ko05145	Toxoplasmosis	4/841	126/7206	0.00110224784675
ko05202	Transcriptional misregulation in cancer	37/841	188/7206	0.00116385370989
ko04721	Synaptic vesicle cycle	1/841	80/7206	0.00120177971629
ko04976	Bile secretion	1/841	80/7206	0.00120177971629
ko05166	HTLV-I infection	52/841	292/7206	0.00149552489305
ko04912	GnRH signaling pathway	4/841	122/7206	0.0015498277166
ko04750	Inflammatory mediator regulation of TRP channels	4/841	122/7206	0.0015498277166
ko00010	Glycolysis / Gluconeogenesis	1/841	74/7206	0.00169397614012
ko05140	Leishmaniasis	1/841	75/7206	0.00170359953434
ko05418	Fluid shear stress and atherosclerosis	8/841	173/7206	0.00172904687338
ko04611	Platelet activation	7/841	163/7206	0.00179725395863
ko04925	Aldosterone synthesis and secretion	3/841	105/7206	0.00194385735155
ko04915	Estrogen signaling pathway	5/841	131/7206	0.00231824546778
ko04920	Adipocytokine signaling pathway	2/841	89/7206	0.00234265146564
ko05030	Cocaine addiction	1/841	73/7206	0.00263102373769
ko05142	Chagas disease (American trypanosomiasis)	5/841	130/7206	0.00333540747021
ko04918	Thyroid hormone synthesis	2/841	86/7206	0.00342938025303
ko05133	Pertussis	2/841	87/7206	0.00354053362719
ko05132	Salmonella infection	3/841	98/7206	0.0039392291568
ko05100	Bacterial invasion of epithelial cells	3/841	99/7206	0.00398586909733
ko00564	Glycerophospholipid metabolism	3/841	99/7206	0.00398586909733
ko04371	Apelin signaling pathway	9/841	177/7206	0.00410719100429
ko04071	Sphingolipid signaling pathway	8/841	162/7206	0.00424772036996
ko04070	Phosphatidylinositol signaling system	4/841	112/7206	0.00432413888642
ko04142	Lysosome	7/841	151/7206	0.00443967974469
ko04712	Circadian rhythm - plant	4/841	7/7206	0.00482116693642
ko04360	Axon guidance	14/841	233/7206	0.00483383247118
ko04141	Protein processing in endoplasmic reticulum	10/841	184/7206	0.00506661864958
ko04152	AMPK signaling pathway	8/841	161/7206	0.00582352489747
ko04933	AGE-RAGE signaling pathway in diabetic complications	6/841	135/7206	0.00621540735648
ko05205	Proteoglycans in cancer	18/841	271/7206	0.00674260346523
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	2/841	79/7206	0.00714896226827
ko05031	Amphetamine addiction	3/841	91/7206	0.00790176825723
ko01212	Fatty acid metabolism	1/841	60/7206	0.00811201676102
ko00600	Sphingolipid metabolism	1/841	63/7206	0.00862907235865
ko04140	Autophagy - animal	9/841	164/7206	0.00947869934291
ko05134	Legionellosis	2/841	74/7206	0.0100609288936
ko04670	Leukocyte transendothelial migration	8/841	151/7206	0.0101364151053
ko04662	B cell receptor signaling pathway	3/841	88/7206	0.0112062742881
ko05323	Rheumatoid arthritis	3/841	89/7206	0.0114239205341
ko01200	Carbon metabolism	6/841	128/7206	0.0115052742865
ko04540	Gap junction	6/841	128/7206	0.0115052742865
ko05231	Choline metabolism in cancer	7/841	134/7206	0.0143661729304
ko04660	T cell receptor signaling pathway	6/841	124/7206	0.0154295981292
ko04658	Th1 and Th2 cell differentiation	4/841	96/7206	0.0159371202498
ko04650	Natural killer cell mediated cytotoxicity	4/841	97/7206	0.0160034734509
ko00520	Amino sugar and nucleotide sugar metabolism	1/841	55/7206	0.0180097754493
ko05321	Inflammatory bowel disease (IBD)	1/841	56/7206	0.0186413159621
ko05152	Tuberculosis	12/841	187/7206	0.0206753025993
ko04659	Th17 cell differentiation	5/841	106/7206	0.0214036441848
ko04512	ECM-receptor interaction	3/841	79/7206	0.0218622137716
ko05120	Epithelial cell signaling in Helicobacter pylori infection	4/841	92/7206	0.0219537768078
ko00670	One carbon pool by folate	6/841	20/7206	0.0227991105471
ko00590	Arachidonic acid metabolism	1/841	52/7206	0.0268357549858
ko04330	Notch signaling pathway	13/841	62/7206	0.0286535829473
ko05110	Vibrio cholerae infection	2/841	63/7206	0.0293752156964
ko00562	Inositol phosphate metabolism	4/841	89/7206	0.0300975269501
ko05167	Kaposi's sarcoma-associated herpesvirus infection	13/841	191/7206	0.0301163199291
ko04923	Regulation of lipolysis in adipocytes	3/841	77/7206	0.0306536851448
ko04931	Insulin resistance	8/841	137/7206	0.0307647488573
ko04730	Long-term depression	3/841	78/7206	0.0311398153496
ko04139	Mitophagy - yeast	9/841	37/7206	0.0334613291289
ko05200	Pathways in cancer	43/841	492/7206	0.0348763158122
ko00260	Glycine, serine and threonine metabolism	1/841	48/7206	0.0387347963054
ko05014	Amyotrophic lateral sclerosis (ALS)	3/841	74/7206	0.042932593551