ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 41/492 191/7206 2.16332326581e-11 ko04512 ECM-receptor interaction 18/492 79/7206 4.21218266886e-06 ko04380 Osteoclast differentiation 24/492 134/7206 1.02584305734e-05 ko04672 Intestinal immune network for IgA production 11/492 37/7206 2.25238128951e-05 ko04611 Platelet activation 26/492 163/7206 4.58107276306e-05 ko04610 Complement and coagulation cascades 16/492 79/7206 6.75904178184e-05 ko05034 Alcoholism 3/492 238/7206 6.94308870961e-05 ko04658 Th1 and Th2 cell differentiation 18/492 96/7206 7.04713498561e-05 ko00565 Ether lipid metabolism 11/492 42/7206 8.24915131906e-05 ko04659 Th17 cell differentiation 18/492 106/7206 0.00026259022736 ko04933 AGE-RAGE signaling pathway in diabetic complications 21/492 135/7206 0.000359778212895 ko05164 Influenza A 24/492 167/7206 0.000467960944332 ko00590 Arachidonic acid metabolism 11/492 52/7206 0.000624395985978 ko03040 Spliceosome 1/492 145/7206 0.000681091244704 ko04110 Cell cycle 1/492 145/7206 0.000681091244704 ko05340 Primary immunodeficiency 8/492 30/7206 0.000682645070716 ko04650 Natural killer cell mediated cytotoxicity 16/492 97/7206 0.000792387817367 ko04660 T cell receptor signaling pathway 19/492 124/7206 0.000829264674158 ko05145 Toxoplasmosis 19/492 126/7206 0.000962409497152 ko05146 Amoebiasis 16/492 99/7206 0.00099518376223 ko04510 Focal adhesion 30/492 240/7206 0.00103617867827 ko05321 Inflammatory bowel disease (IBD) 11/492 56/7206 0.00120090114521 ko00350 Tyrosine metabolism 8/492 33/7206 0.00135056028722 ko03013 RNA transport 2/492 166/7206 0.0014710557884 ko04666 Fc gamma R-mediated phagocytosis 18/492 122/7206 0.00163681640008 ko03010 Ribosome 1/492 129/7206 0.00218723147717 ko04064 NF-kappa B signaling pathway 15/492 96/7206 0.00308266758641 ko04640 Hematopoietic cell lineage 11/492 64/7206 0.00365710205499 ko05140 Leishmaniasis 12/492 75/7206 0.00450180107716 ko00140 Steroid hormone biosynthesis 8/492 41/7206 0.00574286907604 ko04072 Phospholipase D signaling pathway 24/492 197/7206 0.00576272155034 ko04020 Calcium signaling pathway 30/492 265/7206 0.00586351876099 ko04621 NOD-like receptor signaling pathway 20/492 157/7206 0.00594568369646 ko04974 Protein digestion and absorption 14/492 96/7206 0.00639054557457 ko04710 Circadian rhythm 8/492 43/7206 0.00773206350691 ko04668 TNF signaling pathway 16/492 120/7206 0.0091741637097 ko05150 Staphylococcus aureus infection 7/492 36/7206 0.00976591745366 ko05144 Malaria 8/492 45/7206 0.0101991602614 ko05320 Autoimmune thyroid disease 6/492 29/7206 0.0121118184104 ko04630 Jak-STAT signaling pathway 17/492 132/7206 0.0128987025312 ko04810 Regulation of actin cytoskeleton 28/492 264/7206 0.0177178966831 ko05323 Rheumatoid arthritis 12/492 89/7206 0.0190204550869 ko05330 Allograft rejection 5/492 24/7206 0.0209153238243 ko00051 Fructose and mannose metabolism 7/492 42/7206 0.0221975444168 ko04070 Phosphatidylinositol signaling system 14/492 112/7206 0.0229039946564 ko04151 PI3K-Akt signaling pathway 38/492 390/7206 0.0229229033004 ko05231 Choline metabolism in cancer 16/492 134/7206 0.0240470352587 ko05230 Central carbon metabolism in cancer 11/492 81/7206 0.0241760506533 ko05310 Asthma 4/492 17/7206 0.0250433118077 ko00360 Phenylalanine metabolism 4/492 17/7206 0.0250433118077 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/492 4/7206 0.0254497024401 ko00643 Styrene degradation 2/492 4/7206 0.0254497024401 ko00950 Isoquinoline alkaloid biosynthesis 3/492 10/7206 0.0264475069585 ko04912 GnRH signaling pathway 15/492 122/7206 0.0270333974362 ko05203 Viral carcinogenesis 10/492 277/7206 0.0281749159772 ko05332 Graft-versus-host disease 4/492 18/7206 0.0305089489317 ko00592 alpha-Linolenic acid metabolism 4/492 19/7206 0.0366224328599 ko05016 Huntington's disease 7/492 215/7206 0.0378873875223 ko05152 Tuberculosis 20/492 187/7206 0.0393993396114 ko04664 Fc epsilon RI signaling pathway 10/492 77/7206 0.0398096639083 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/492 5/7206 0.0405153581777 ko00281 Geraniol degradation 2/492 5/7206 0.0405153581777 ko05132 Salmonella infection 12/492 98/7206 0.041733253861 ko04721 Synaptic vesicle cycle 1/492 80/7206 0.0427456534915 ko05166 HTLV-I infection 29/492 292/7206 0.0427783891554 ko00120 Primary bile acid biosynthesis 4/492 20/7206 0.0433892544461 ko00564 Glycerophospholipid metabolism 12/492 99/7206 0.0436666377726 ko04620 Toll-like receptor signaling pathway 12/492 100/7206 0.0457456203759 ko04750 Inflammatory mediator regulation of TRP channels 14/492 122/7206 0.0463246082373 ko04670 Leukocyte transendothelial migration 17/492 151/7206 0.0476088551359 ko05160 Hepatitis C 17/492 153/7206 0.0491074971738