ko pathway ratio_in_study ratio_in_pop p_value ko04911 Insulin secretion 23/332 117/7206 2.30664440391e-09 ko04725 Cholinergic synapse 27/332 160/7206 3.15165647141e-09 ko04745 Phototransduction - fly 12/332 38/7206 6.88552072077e-08 ko04713 Circadian entrainment 22/332 136/7206 2.07204832968e-07 ko04724 Glutamatergic synapse 23/332 152/7206 3.79008953781e-07 ko04728 Dopaminergic synapse 25/332 185/7206 1.0530816452e-06 ko04971 Gastric acid secretion 17/332 98/7206 1.90728497802e-06 ko04720 Long-term potentiation 17/332 99/7206 2.20764630873e-06 ko04360 Axon guidance 28/332 233/7206 2.59204469491e-06 ko04721 Synaptic vesicle cycle 15/332 80/7206 2.82698335376e-06 ko04070 Phosphatidylinositol signaling system 18/332 112/7206 2.98751754459e-06 ko05031 Amphetamine addiction 16/332 91/7206 3.19607287095e-06 ko04726 Serotonergic synapse 20/332 137/7206 3.92690814695e-06 ko04925 Aldosterone synthesis and secretion 16/332 105/7206 2.13221957066e-05 ko04020 Calcium signaling pathway 28/332 265/7206 3.32971702608e-05 ko04750 Inflammatory mediator regulation of TRP channels 17/332 122/7206 3.89778866272e-05 ko04966 Collecting duct acid secretion 7/332 26/7206 0.000127337269104 ko04921 Oxytocin signaling pathway 23/332 209/7206 0.000129838707938 ko04024 cAMP signaling pathway 27/332 279/7206 0.000211993512579 ko04960 Aldosterone-regulated sodium reabsorption 8/332 41/7206 0.000469379400924 ko05032 Morphine addiction 14/332 110/7206 0.000488171278437 ko04261 Adrenergic signaling in cardiomyocytes 21/332 205/7206 0.000517650966973 ko04922 Glucagon signaling pathway 15/332 128/7206 0.000754243631866 ko04919 Thyroid hormone signaling pathway 16/332 143/7206 0.000846415459388 ko05214 Glioma 11/332 79/7206 0.000912989634916 ko04626 Plant-pathogen interaction 5/332 18/7206 0.00104990616838 ko04970 Salivary secretion 12/332 95/7206 0.00130388038539 ko04961 Endocrine and other factor-regulated calcium reabsorption 9/332 59/7206 0.00137212699237 ko04912 GnRH signaling pathway 14/332 122/7206 0.00137948850945 ko04727 GABAergic synapse 13/332 110/7206 0.00154867483299 ko04964 Proximal tubule bicarbonate reclamation 6/332 29/7206 0.0017643274401 ko04918 Thyroid hormone synthesis 11/332 86/7206 0.00185483221154 ko05110 Vibrio cholerae infection 9/332 63/7206 0.0021987823615 ko04022 cGMP-PKG signaling pathway 20/332 216/7206 0.00257020791046 ko04080 Neuroactive ligand-receptor interaction 33/332 423/7206 0.00258266382891 ko04973 Carbohydrate digestion and absorption 7/332 42/7206 0.00276926110862 ko04014 Ras signaling pathway 24/332 279/7206 0.00307806725647 ko04916 Melanogenesis 15/332 142/7206 0.00333129556798 ko04740 Olfactory transduction 10/332 80/7206 0.00350304298596 ko04066 HIF-1 signaling pathway 13/332 123/7206 0.00419325254115 ko04972 Pancreatic secretion 12/332 111/7206 0.00487283725329 ko04540 Gap junction 13/332 128/7206 0.00814253620442 ko04370 VEGF signaling pathway 9/332 77/7206 0.00853573775286 ko04723 Retrograde endocannabinoid signaling 16/332 175/7206 0.00891659520704 ko05120 Epithelial cell signaling in Helicobacter pylori infection 10/332 92/7206 0.00943910485929 ko00910 Nitrogen metabolism 4/332 19/7206 0.00989657174314 ko04015 Rap1 signaling pathway 22/332 278/7206 0.0122250839859 ko05202 Transcriptional misregulation in cancer 2/332 188/7206 0.0125238352391 ko04650 Natural killer cell mediated cytotoxicity 10/332 97/7206 0.0134584090546 ko03040 Spliceosome 1/332 145/7206 0.0149132983254 ko04110 Cell cycle 1/332 145/7206 0.0149132983254 ko04062 Chemokine signaling pathway 17/332 201/7206 0.0151518966764 ko04012 ErbB signaling pathway 11/332 109/7206 0.0170102890378 ko05168 Herpes simplex infection 2/332 182/7206 0.0180030610289 ko00680 Methane metabolism 5/332 34/7206 0.0186576535235 ko00010 Glycolysis / Gluconeogenesis 8/332 74/7206 0.0199058736519 ko05323 Rheumatoid arthritis 9/332 89/7206 0.0208332381956 ko04071 Sphingolipid signaling pathway 14/332 162/7206 0.0210077585784 ko04145 Phagosome 14/332 162/7206 0.0210077585784 ko04310 Wnt signaling pathway 15/332 181/7206 0.0283155496658 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 3/332 15/7206 0.0291936939397 ko05223 Non-small cell lung cancer 7/332 66/7206 0.0313219021007 ko05230 Central carbon metabolism in cancer 8/332 81/7206 0.0322746966109 ko05152 Tuberculosis 15/332 187/7206 0.0323676920738 ko04114 Oocyte meiosis 12/332 139/7206 0.0367312058867 ko00051 Fructose and mannose metabolism 5/332 42/7206 0.0423950078967 ko04371 Apelin signaling pathway 14/332 177/7206 0.0436978052582 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/332 1/7206 0.0460727171803 ko04710 Circadian rhythm 5/332 43/7206 0.0462377295247 ko00190 Oxidative phosphorylation 11/332 127/7206 0.0490837154571