ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 88/618 145/7206 4.6142062083e-58 ko04110 Cell cycle 59/618 145/7206 1.99937845255e-26 ko03030 DNA replication 29/618 38/7206 4.89019041216e-24 ko04111 Cell cycle - yeast 42/618 90/7206 7.12896357548e-22 ko03013 RNA transport 51/618 166/7206 9.68102604134e-17 ko03008 Ribosome biogenesis in eukaryotes 34/618 79/7206 1.42985505429e-16 ko03460 Fanconi anemia pathway 27/618 51/7206 2.94111594641e-16 ko03410 Base excision repair 23/618 38/7206 8.95023639412e-16 ko04080 Neuroactive ligand-receptor interaction 1/618 423/7206 1.03149678757e-15 ko03440 Homologous recombination 22/618 41/7206 1.22663790132e-13 ko04113 Meiosis - yeast 28/618 70/7206 6.6523525306e-13 ko03430 Mismatch repair 15/618 22/7206 8.21230649365e-12 ko03420 Nucleotide excision repair 20/618 46/7206 2.2896921133e-10 ko00240 Pyrimidine metabolism 32/618 110/7206 2.93158007064e-10 ko03015 mRNA surveillance pathway 29/618 93/7206 3.26709979066e-10 ko04020 Calcium signaling pathway 1/618 265/7206 1.70279598545e-09 ko04144 Endocytosis 5/618 342/7206 1.54899568679e-08 ko05010 Alzheimer's disease 1/618 202/7206 3.29970834042e-07 ko04060 Cytokine-cytokine receptor interaction 1/618 191/7206 1.14048620561e-06 ko04621 NOD-like receptor signaling pathway 1/618 157/7206 1.8128904975e-05 ko04142 Lysosome 1/618 151/7206 2.69531166644e-05 ko04270 Vascular smooth muscle contraction 1/618 154/7206 2.76813620269e-05 ko05012 Parkinson's disease 1/618 155/7206 2.85590121976e-05 ko05166 HTLV-I infection 46/618 292/7206 4.06079500658e-05 ko04024 cAMP signaling pathway 7/618 279/7206 4.30718674563e-05 ko05322 Systemic lupus erythematosus 29/618 151/7206 4.34542105763e-05 ko03018 RNA degradation 19/618 84/7206 6.63358899011e-05 ko04145 Phagosome 2/618 162/7206 9.56032223281e-05 ko05203 Viral carcinogenesis 43/618 277/7206 0.000106760798951 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/618 182/7206 0.000131928145944 ko04510 Focal adhesion 6/618 240/7206 0.000148447788398 ko04723 Retrograde endocannabinoid signaling 3/618 175/7206 0.000188099584291 ko04514 Cell adhesion molecules (CAMs) 1/618 130/7206 0.000194691891799 ko04724 Glutamatergic synapse 2/618 152/7206 0.000202820486739 ko03022 Basal transcription factors 12/618 44/7206 0.000231132739381 ko04022 cGMP-PKG signaling pathway 5/618 216/7206 0.000276300167362 ko04921 Oxytocin signaling pathway 5/618 209/7206 0.000372400235611 ko04530 Tight junction 6/618 228/7206 0.000409619041113 ko04261 Adrenergic signaling in cardiomyocytes 5/618 205/7206 0.00052673467557 ko04010 MAPK signaling pathway 12/618 321/7206 0.000708114358601 ko04072 Phospholipase D signaling pathway 5/618 197/7206 0.000719390726646 ko04062 Chemokine signaling pathway 5/618 201/7206 0.000746265101985 ko04380 Osteoclast differentiation 2/618 134/7206 0.000896798142272 ko04972 Pancreatic secretion 1/618 111/7206 0.000919137125879 ko04070 Phosphatidylinositol signaling system 1/618 112/7206 0.000933752121308 ko04114 Oocyte meiosis 24/618 139/7206 0.00101522038669 ko04810 Regulation of actin cytoskeleton 9/618 264/7206 0.00106439773664 ko04914 Progesterone-mediated oocyte maturation 19/618 104/7206 0.00126766348105 ko04015 Rap1 signaling pathway 10/618 278/7206 0.00139366149628 ko04014 Ras signaling pathway 10/618 279/7206 0.0014092873173 ko04218 Cellular senescence 28/618 177/7206 0.00149590305206 ko04120 Ubiquitin mediated proteolysis 23/618 138/7206 0.0017838036254 ko04620 Toll-like receptor signaling pathway 1/618 100/7206 0.00198032603081 ko05202 Transcriptional misregulation in cancer 29/618 188/7206 0.00207006576399 ko03020 RNA polymerase 8/618 29/7206 0.00236601682558 ko04725 Cholinergic synapse 4/618 160/7206 0.0025061305847 ko04668 TNF signaling pathway 2/618 120/7206 0.00268740696838 ko04912 GnRH signaling pathway 2/618 122/7206 0.00276418695228 ko04750 Inflammatory mediator regulation of TRP channels 2/618 122/7206 0.00276418695228 ko04650 Natural killer cell mediated cytotoxicity 1/618 97/7206 0.00292093501424 ko04971 Gastric acid secretion 1/618 98/7206 0.00296541862027 ko05146 Amoebiasis 1/618 99/7206 0.00303798707811 ko04726 Serotonergic synapse 3/618 137/7206 0.00317833987742 ko05418 Fluid shear stress and atherosclerosis 5/618 173/7206 0.00365666814641 ko04911 Insulin secretion 2/618 117/7206 0.00394617064915 ko05120 Epithelial cell signaling in Helicobacter pylori infection 1/618 92/7206 0.00427111541936 ko05231 Choline metabolism in cancer 3/618 134/7206 0.00451377245127 ko04713 Circadian entrainment 3/618 136/7206 0.00465955042518 ko04670 Leukocyte transendothelial migration 4/618 151/7206 0.00485894264019 ko04115 p53 signaling pathway 14/618 74/7206 0.00490890455513 ko04728 Dopaminergic synapse 6/618 185/7206 0.00503771052091 ko04151 PI3K-Akt signaling pathway 19/618 390/7206 0.00518973528798 ko04727 GABAergic synapse 2/618 110/7206 0.00551277078805 ko04330 Notch signaling pathway 12/618 62/7206 0.00568801329345 ko05034 Alcoholism 33/618 238/7206 0.00628086243478 ko04662 B cell receptor signaling pathway 1/618 88/7206 0.00629973667116 ko01200 Carbon metabolism 3/618 128/7206 0.00630183022702 ko00562 Inositol phosphate metabolism 1/618 89/7206 0.00641279998388 ko04915 Estrogen signaling pathway 3/618 131/7206 0.00652298483164 ko04611 Platelet activation 5/618 163/7206 0.00687009324846 ko04659 Th17 cell differentiation 2/618 106/7206 0.00791246566186 ko04371 Apelin signaling pathway 6/618 177/7206 0.00924775223464 ko04722 Neurotrophin signaling pathway 5/618 160/7206 0.00945322045271 ko05168 Herpes simplex infection 26/618 182/7206 0.0100042858245 ko05205 Proteoglycans in cancer 12/618 271/7206 0.0105900518684 ko00230 Purine metabolism 27/618 194/7206 0.0126249524379 ko04933 AGE-RAGE signaling pathway in diabetic complications 4/618 135/7206 0.0127849194259 ko04610 Complement and coagulation cascades 1/618 79/7206 0.0135232886641 ko04740 Olfactory transduction 1/618 80/7206 0.013798920157 ko05152 Tuberculosis 7/618 187/7206 0.0161870015347 ko05132 Salmonella infection 2/618 98/7206 0.0163693937205 ko04360 Axon guidance 10/618 233/7206 0.0166050667312 ko05100 Bacterial invasion of epithelial cells 2/618 99/7206 0.0167173779302 ko00564 Glycerophospholipid metabolism 2/618 99/7206 0.0167173779302 ko05142 Chagas disease (American trypanosomiasis) 4/618 130/7206 0.0175371054688 ko04630 Jak-STAT signaling pathway 4/618 132/7206 0.0176107873749 ko05134 Legionellosis 1/618 74/7206 0.0196197961089 ko05140 Leishmaniasis 1/618 75/7206 0.0199653195438 ko04071 Sphingolipid signaling pathway 6/618 162/7206 0.0222641204869 ko05031 Amphetamine addiction 2/618 91/7206 0.022638944291 ko05145 Toxoplasmosis 4/618 126/7206 0.0239563321022 ko05032 Morphine addiction 3/618 110/7206 0.0241186794469 ko04922 Glucagon signaling pathway 4/618 128/7206 0.0242572067372 ko04540 Gap junction 4/618 128/7206 0.0242572067372 ko04924 Renin secretion 2/618 86/7206 0.0319669507001 ko05133 Pertussis 2/618 87/7206 0.0321666285832 ko04666 Fc gamma R-mediated phagocytosis 4/618 122/7206 0.0327267360581 ko04066 HIF-1 signaling pathway 4/618 123/7206 0.0329866831273 ko04520 Adherens junction 3/618 103/7206 0.0330298486374 ko04146 Peroxisome 2/618 89/7206 0.0331255829436 ko04925 Aldosterone synthesis and secretion 3/618 105/7206 0.0333243891314 ko04660 T cell receptor signaling pathway 4/618 124/7206 0.0333820781952 ko05110 Vibrio cholerae infection 1/618 63/7206 0.0409331534634 ko00561 Glycerolipid metabolism 1/618 63/7206 0.0409331534634 ko04931 Insulin resistance 5/618 137/7206 0.0430224814137 ko04141 Protein processing in endoplasmic reticulum 8/618 184/7206 0.0438077701171 ko05230 Central carbon metabolism in cancer 2/618 81/7206 0.0449916609083 ko04138 Autophagy - yeast 2/618 81/7206 0.0449916609083 ko04137 Mitophagy - animal 2/618 82/7206 0.0452293872569 ko04720 Long-term potentiation 3/618 99/7206 0.0455828259463 ko04140 Autophagy - animal 7/618 164/7206 0.0472124858798