ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1182	423/7206	1.97317288297e-53
ko04724	Glutamatergic synapse	93/1182	152/7206	2.09149353235e-36
ko05033	Nicotine addiction	50/1182	56/7206	2.72836468491e-33
ko05032	Morphine addiction	72/1182	110/7206	4.08036982683e-31
ko04727	GABAergic synapse	69/1182	110/7206	3.60846438172e-28
ko04713	Circadian entrainment	78/1182	136/7206	5.77085490328e-28
ko04728	Dopaminergic synapse	89/1182	185/7206	2.41034982127e-24
ko04725	Cholinergic synapse	79/1182	160/7206	1.2721259972e-22
ko04723	Retrograde endocannabinoid signaling	81/1182	175/7206	6.90436183716e-21
ko04721	Synaptic vesicle cycle	50/1182	80/7206	1.29982689696e-20
ko04024	cAMP signaling pathway	104/1182	279/7206	9.0583268444e-18
ko04020	Calcium signaling pathway	99/1182	265/7206	6.33508035802e-17
ko04726	Serotonergic synapse	63/1182	137/7206	2.57053659017e-16
ko04911	Insulin secretion	57/1182	117/7206	2.71352002862e-16
ko04744	Phototransduction	28/1182	36/7206	6.24723414198e-16
ko05031	Amphetamine addiction	47/1182	91/7206	6.77091542689e-15
ko04742	Taste transduction	36/1182	61/7206	4.47545266447e-14
ko04921	Oxytocin signaling pathway	77/1182	209/7206	3.668514989e-13
ko04720	Long-term potentiation	47/1182	99/7206	3.9838144192e-13
ko04740	Olfactory transduction	38/1182	80/7206	7.14893584055e-11
ko04970	Salivary secretion	42/1182	95/7206	1.26984701476e-10
ko03040	Spliceosome	1/1182	145/7206	1.92402901763e-10
ko04261	Adrenergic signaling in cardiomyocytes	70/1182	205/7206	3.02541139927e-10
ko04925	Aldosterone synthesis and secretion	44/1182	105/7206	3.87731348278e-10
ko03010	Ribosome	1/1182	129/7206	4.21876226416e-09
ko05030	Cocaine addiction	33/1182	73/7206	6.25371078065e-09
ko05322	Systemic lupus erythematosus	4/1182	151/7206	8.71507722303e-08
ko04971	Gastric acid secretion	38/1182	98/7206	9.69469242965e-08
ko04070	Phosphatidylinositol signaling system	40/1182	112/7206	5.032245208e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1182	74/7206	5.81804212913e-07
ko04060	Cytokine-cytokine receptor interaction	9/1182	191/7206	8.21784238614e-07
ko04072	Phospholipase D signaling pathway	59/1182	197/7206	1.93077630048e-06
ko03013	RNA transport	7/1182	166/7206	1.950884869e-06
ko04022	cGMP-PKG signaling pathway	63/1182	216/7206	2.19964446148e-06
ko04730	Long-term depression	30/1182	78/7206	2.96490568017e-06
ko05168	Herpes simplex infection	9/1182	182/7206	3.49108386399e-06
ko04750	Inflammatory mediator regulation of TRP channels	40/1182	122/7206	6.25625750747e-06
ko05203	Viral carcinogenesis	20/1182	277/7206	6.46812014055e-06
ko04010	MAPK signaling pathway	83/1182	321/7206	9.64429240074e-06
ko04540	Gap junction	41/1182	128/7206	9.93210161638e-06
ko04966	Collecting duct acid secretion	14/1182	26/7206	1.2965553168e-05
ko04514	Cell adhesion molecules (CAMs)	41/1182	130/7206	1.93692469419e-05
ko04972	Pancreatic secretion	36/1182	111/7206	2.51611002709e-05
ko04141	Protein processing in endoplasmic reticulum	11/1182	184/7206	2.82960734564e-05
ko04360	Axon guidance	63/1182	233/7206	2.96142733722e-05
ko04612	Antigen processing and presentation	1/1182	77/7206	3.18442363879e-05
ko04110	Cell cycle	7/1182	145/7206	3.35462380755e-05
ko04745	Phototransduction - fly	17/1182	38/7206	3.6645406894e-05
ko04120	Ubiquitin mediated proteolysis	7/1182	138/7206	6.5172513268e-05
ko04621	NOD-like receptor signaling pathway	9/1182	157/7206	7.22952900266e-05
ko05164	Influenza A	10/1182	167/7206	7.45642034799e-05
ko04924	Renin secretion	29/1182	86/7206	8.95276661357e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1182	79/7206	9.26182931454e-05
ko05110	Vibrio cholerae infection	23/1182	63/7206	9.81048053003e-05
ko04014	Ras signaling pathway	70/1182	279/7206	0.000139428479385
ko03008	Ribosome biogenesis in eukaryotes	2/1182	79/7206	0.00017230284423
ko05414	Dilated cardiomyopathy	34/1182	112/7206	0.000245338244739
ko04915	Estrogen signaling pathway	37/1182	131/7206	0.000509354402914
ko05162	Measles	7/1182	120/7206	0.000699702057872
ko00520	Amino sugar and nucleotide sugar metabolism	1/1182	55/7206	0.00137637392169
ko05169	Epstein-Barr virus infection	18/1182	206/7206	0.00157731401571
ko04976	Bile secretion	24/1182	80/7206	0.00210486802022
ko04260	Cardiac muscle contraction	28/1182	98/7206	0.00223459194452
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1182	59/7206	0.00232158556999
ko00240	Pyrimidine metabolism	7/1182	110/7206	0.00257917966501
ko04923	Regulation of lipolysis in adipocytes	23/1182	77/7206	0.00287160758737
ko04630	Jak-STAT signaling pathway	10/1182	132/7206	0.00412992738006
ko03420	Nucleotide excision repair	1/1182	46/7206	0.00441073239519
ko04626	Plant-pathogen interaction	8/1182	18/7206	0.00477235151407
ko04960	Aldosterone-regulated sodium reabsorption	14/1182	41/7206	0.00482726771024
ko04930	Type II diabetes mellitus	17/1182	54/7206	0.0051291877015
ko04912	GnRH signaling pathway	32/1182	122/7206	0.00616288972909
ko05231	Choline metabolism in cancer	34/1182	134/7206	0.00662317293237
ko03022	Basal transcription factors	1/1182	44/7206	0.00670289521076
ko05140	Leishmaniasis	4/1182	75/7206	0.00692603803111
ko00071	Fatty acid degradation	1/1182	45/7206	0.00704651048804
ko04922	Glucagon signaling pathway	33/1182	128/7206	0.00752676921724
ko04918	Thyroid hormone synthesis	24/1182	86/7206	0.00754041811458
ko04330	Notch signaling pathway	3/1182	62/7206	0.00920459043852
ko04622	RIG-I-like receptor signaling pathway	3/1182	62/7206	0.00920459043852
ko05205	Proteoglycans in cancer	29/1182	271/7206	0.00929713541126
ko04146	Peroxisome	6/1182	89/7206	0.00936165239964
ko05131	Shigellosis	5/1182	82/7206	0.00984667775646
ko00310	Lysine degradation	4/1182	73/7206	0.0099332224165
ko04710	Circadian rhythm	14/1182	43/7206	0.0109584473897
ko04658	Th1 and Th2 cell differentiation	7/1182	96/7206	0.0121039355944
ko04064	NF-kappa B signaling pathway	7/1182	96/7206	0.0121039355944
ko00590	Arachidonic acid metabolism	2/1182	52/7206	0.0127236694278
ko04657	IL-17 signaling pathway	6/1182	87/7206	0.0127805281617
ko05133	Pertussis	6/1182	87/7206	0.0127805281617
ko04610	Complement and coagulation cascades	5/1182	79/7206	0.013473457658
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1182	100/7206	0.0136429965652
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1182	182/7206	0.0146797296075
ko00630	Glyoxylate and dicarboxylate metabolism	1/1182	38/7206	0.0148295111775
ko03410	Base excision repair	1/1182	38/7206	0.0148295111775
ko04270	Vascular smooth muscle contraction	37/1182	154/7206	0.0149136694635
ko04350	TGF-beta signaling pathway	8/1182	103/7206	0.0152038976531
ko04062	Chemokine signaling pathway	46/1182	201/7206	0.0154064935166
ko05161	Hepatitis B	17/1182	173/7206	0.0165242056091
ko03018	RNA degradation	6/1182	84/7206	0.0173911241462
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1182	14/7206	0.0175933464232
ko05219	Bladder cancer	2/1182	48/7206	0.0175999903656
ko04973	Carbohydrate digestion and absorption	13/1182	42/7206	0.0189393069361
ko05016	Huntington's disease	23/1182	215/7206	0.019405600351
ko05145	Toxoplasmosis	11/1182	126/7206	0.0202448268182
ko04015	Rap1 signaling pathway	60/1182	278/7206	0.0205669108333
ko00562	Inositol phosphate metabolism	23/1182	89/7206	0.0206190878804
ko05214	Glioma	21/1182	79/7206	0.0207474777293
ko04916	Melanogenesis	34/1182	142/7206	0.0212822373314
ko05166	HTLV-I infection	34/1182	292/7206	0.0237812971989
ko04214	Apoptosis - fly	5/1182	72/7206	0.0250506867042
ko05144	Malaria	2/1182	45/7206	0.0253843784551
ko04115	p53 signaling pathway	5/1182	74/7206	0.0255938675077
ko00280	Valine, leucine and isoleucine degradation	3/1182	54/7206	0.0263822102011
ko05321	Inflammatory bowel disease (IBD)	3/1182	56/7206	0.0274166588478
ko05418	Fluid shear stress and atherosclerosis	18/1182	173/7206	0.0290179096949
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1182	92/7206	0.0325562590626
ko00860	Porphyrin and chlorophyll metabolism	1/1182	34/7206	0.0335916067967
ko04114	Oocyte meiosis	32/1182	139/7206	0.0373803265086
ko00230	Purine metabolism	43/1182	194/7206	0.0383178041428
ko04217	Necroptosis	19/1182	178/7206	0.0397232545721
ko04964	Proximal tubule bicarbonate reclamation	9/1182	29/7206	0.0429014045882
ko04711	Circadian rhythm - fly	5/1182	13/7206	0.0480108336377
ko05340	Primary immunodeficiency	1/1182	30/7206	0.0491728084346