ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1181	423/7206	5.89454495955e-55
ko04724	Glutamatergic synapse	92/1181	152/7206	1.65838691808e-35
ko05033	Nicotine addiction	49/1181	56/7206	9.97642611637e-32
ko05032	Morphine addiction	68/1181	110/7206	3.03619918189e-27
ko04713	Circadian entrainment	77/1181	136/7206	3.90726704089e-27
ko04727	GABAergic synapse	67/1181	110/7206	2.59181669305e-26
ko04721	Synaptic vesicle cycle	54/1181	80/7206	1.33080618737e-24
ko04725	Cholinergic synapse	78/1181	160/7206	6.2832134389e-22
ko04728	Dopaminergic synapse	85/1181	185/7206	1.24127276238e-21
ko04723	Retrograde endocannabinoid signaling	78/1181	175/7206	6.0080665154e-19
ko04020	Calcium signaling pathway	100/1181	265/7206	1.23652752755e-17
ko04024	cAMP signaling pathway	103/1181	279/7206	2.31732250094e-17
ko04911	Insulin secretion	58/1181	117/7206	5.04178462155e-17
ko04742	Taste transduction	39/1181	61/7206	7.38956871294e-17
ko04726	Serotonergic synapse	62/1181	137/7206	1.10956605923e-15
ko04744	Phototransduction	27/1181	36/7206	9.99800702105e-15
ko04921	Oxytocin signaling pathway	79/1181	209/7206	3.25835262644e-14
ko04720	Long-term potentiation	47/1181	99/7206	3.85768648872e-13
ko04740	Olfactory transduction	41/1181	80/7206	5.0334625608e-13
ko05031	Amphetamine addiction	43/1181	91/7206	4.79145421819e-12
ko04261	Adrenergic signaling in cardiomyocytes	73/1181	205/7206	1.01433723873e-11
ko04970	Salivary secretion	42/1181	95/7206	1.23521017114e-10
ko03040	Spliceosome	1/1181	145/7206	1.92696493823e-10
ko04925	Aldosterone synthesis and secretion	43/1181	105/7206	1.42146676987e-09
ko04971	Gastric acid secretion	39/1181	98/7206	2.1570634387e-08
ko05030	Cocaine addiction	32/1181	73/7206	2.60665557096e-08
ko05203	Viral carcinogenesis	15/1181	277/7206	2.90937375718e-08
ko05168	Herpes simplex infection	6/1181	182/7206	3.68292136564e-08
ko04360	Axon guidance	71/1181	233/7206	6.52869294638e-08
ko04540	Gap junction	46/1181	128/7206	8.20185750085e-08
ko04022	cGMP-PKG signaling pathway	65/1181	216/7206	3.19685010466e-07
ko04060	Cytokine-cytokine receptor interaction	9/1181	191/7206	8.2227089629e-07
ko03013	RNA transport	7/1181	166/7206	1.93998914114e-06
ko04966	Collecting duct acid secretion	15/1181	26/7206	1.94436438573e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1181	74/7206	2.01785924004e-06
ko04260	Cardiac muscle contraction	35/1181	98/7206	2.79990342967e-06
ko04010	MAPK signaling pathway	85/1181	321/7206	2.98741938265e-06
ko04972	Pancreatic secretion	38/1181	111/7206	3.43006432985e-06
ko04120	Ubiquitin mediated proteolysis	5/1181	138/7206	3.87199300408e-06
ko04621	NOD-like receptor signaling pathway	7/1181	157/7206	5.51538375693e-06
ko04514	Cell adhesion molecules (CAMs)	42/1181	130/7206	6.19160884473e-06
ko04141	Protein processing in endoplasmic reticulum	10/1181	184/7206	7.19029007065e-06
ko04730	Long-term depression	29/1181	78/7206	7.74980286852e-06
ko05322	Systemic lupus erythematosus	7/1181	151/7206	1.12524278532e-05
ko04610	Complement and coagulation cascades	1/1181	79/7206	2.03734709408e-05
ko04924	Renin secretion	30/1181	86/7206	2.43221879216e-05
ko04745	Phototransduction - fly	17/1181	38/7206	3.62345214606e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1181	79/7206	3.91631569475e-05
ko05164	Influenza A	10/1181	167/7206	7.44334927699e-05
ko05110	Vibrio cholerae infection	23/1181	63/7206	9.70789814664e-05
ko04110	Cell cycle	8/1181	145/7206	9.74781794926e-05
ko04750	Inflammatory mediator regulation of TRP channels	37/1181	122/7206	0.000104200484048
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1181	59/7206	0.000108450711956
ko05169	Epstein-Barr virus infection	15/1181	206/7206	0.000121497446411
ko03008	Ribosome biogenesis in eukaryotes	2/1181	79/7206	0.000172118846938
ko04072	Phospholipase D signaling pathway	53/1181	197/7206	0.000179160267431
ko05414	Dilated cardiomyopathy	34/1181	112/7206	0.000243951836541
ko04070	Phosphatidylinositol signaling system	34/1181	112/7206	0.000243951836541
ko04612	Antigen processing and presentation	2/1181	77/7206	0.00026160097386
ko04014	Ras signaling pathway	69/1181	279/7206	0.000263011682685
ko05140	Leishmaniasis	2/1181	75/7206	0.000400680731452
ko05205	Proteoglycans in cancer	24/1181	271/7206	0.000406468103355
ko04064	NF-kappa B signaling pathway	4/1181	96/7206	0.000408938291071
ko04915	Estrogen signaling pathway	37/1181	131/7206	0.000503964111087
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1181	14/7206	0.000602412951342
ko05162	Measles	7/1181	120/7206	0.000700135228384
ko04146	Peroxisome	4/1181	89/7206	0.000826105538906
ko04976	Bile secretion	25/1181	80/7206	0.00112616737261
ko00480	Glutathione metabolism	1/1181	55/7206	0.0013730649723
ko04371	Apelin signaling pathway	45/1181	177/7206	0.0018970636432
ko04214	Apoptosis - fly	3/1181	72/7206	0.00216313137677
ko00310	Lysine degradation	3/1181	73/7206	0.00217206488745
ko00240	Pyrimidine metabolism	7/1181	110/7206	0.00257798339151
ko00330	Arginine and proline metabolism	2/1181	61/7206	0.00265431639749
ko04964	Proximal tubule bicarbonate reclamation	11/1181	29/7206	0.00431583779731
ko03420	Nucleotide excision repair	1/1181	46/7206	0.00441168421393
ko05161	Hepatitis B	15/1181	173/7206	0.00471554928071
ko04626	Plant-pathogen interaction	8/1181	18/7206	0.00474673643487
ko04657	IL-17 signaling pathway	5/1181	87/7206	0.00505420677271
ko05321	Inflammatory bowel disease (IBD)	2/1181	56/7206	0.00572201288308
ko05166	HTLV-I infection	31/1181	292/7206	0.0058983678174
ko04912	GnRH signaling pathway	32/1181	122/7206	0.00614497737529
ko03022	Basal transcription factors	1/1181	44/7206	0.00669944817098
ko03018	RNA degradation	5/1181	84/7206	0.00697909883864
ko05144	Malaria	1/1181	45/7206	0.00703342868811
ko00071	Fatty acid degradation	1/1181	45/7206	0.00703342868811
ko04923	Regulation of lipolysis in adipocytes	22/1181	77/7206	0.0075764674231
ko05418	Fluid shear stress and atherosclerosis	16/1181	173/7206	0.00901181289501
ko04622	RIG-I-like receptor signaling pathway	3/1181	62/7206	0.00920939733432
ko04640	Hematopoietic cell lineage	3/1181	64/7206	0.00967005188553
ko04658	Th1 and Th2 cell differentiation	7/1181	96/7206	0.0121091919718
ko00590	Arachidonic acid metabolism	2/1181	52/7206	0.0127016945632
ko05133	Pertussis	6/1181	87/7206	0.0127845526797
ko04015	Rap1 signaling pathway	61/1181	278/7206	0.0130681457841
ko00562	Inositol phosphate metabolism	24/1181	89/7206	0.0132578590211
ko03320	PPAR signaling pathway	4/1181	69/7206	0.0134694388374
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1181	100/7206	0.0135870977357
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1181	182/7206	0.0146810901151
ko00630	Glyoxylate and dicarboxylate metabolism	1/1181	38/7206	0.0148384269172
ko03410	Base excision repair	1/1181	38/7206	0.0148384269172
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1181	40/7206	0.0157852032913
ko00260	Glycine, serine and threonine metabolism	2/1181	48/7206	0.0175988217183
ko01524	Platinum drug resistance	5/1181	76/7206	0.0184052347157
ko05145	Toxoplasmosis	11/1181	126/7206	0.0202117591099
ko04270	Vascular smooth muscle contraction	36/1181	154/7206	0.0208971331412
ko04916	Melanogenesis	34/1181	142/7206	0.0212328494165
ko00982	Drug metabolism - cytochrome P450	1/1181	37/7206	0.0229510964485
ko04630	Jak-STAT signaling pathway	12/1181	132/7206	0.0233306772934
ko04217	Necroptosis	18/1181	178/7206	0.0234797009418
ko05131	Shigellosis	6/1181	82/7206	0.0236273552821
ko04115	p53 signaling pathway	5/1181	74/7206	0.0255644714451
ko05034	Alcoholism	52/1181	238/7206	0.0256242220878
ko04062	Chemokine signaling pathway	45/1181	201/7206	0.0257106855428
ko00600	Sphingolipid metabolism	4/1181	63/7206	0.0261086893116
ko00280	Valine, leucine and isoleucine degradation	3/1181	54/7206	0.0263959935349
ko04918	Thyroid hormone synthesis	22/1181	86/7206	0.0270707980053
ko04350	TGF-beta signaling pathway	9/1181	103/7206	0.0318759720927
ko04668	TNF signaling pathway	11/1181	120/7206	0.0335354594725
ko00500	Starch and sucrose metabolism	1/1181	35/7206	0.0351584741646
ko00983	Drug metabolism - other enzymes	2/1181	42/7206	0.0366526053463
ko04330	Notch signaling pathway	4/1181	62/7206	0.0367101223219
ko04922	Glucagon signaling pathway	30/1181	128/7206	0.0395020246872
ko04930	Type II diabetes mellitus	15/1181	54/7206	0.0395173033829
ko04722	Neurotrophin signaling pathway	36/1181	160/7206	0.0398786709137
ko04620	Toll-like receptor signaling pathway	9/1181	100/7206	0.0416213828709
ko05231	Choline metabolism in cancer	31/1181	134/7206	0.0441513225036
ko05214	Glioma	20/1181	79/7206	0.0450183718363
ko05217	Basal cell carcinoma	5/1181	68/7206	0.0467184282843