ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 67/965 152/7206 6.47826890286e-21 ko04080 Neuroactive ligand-receptor interaction 124/965 423/7206 6.45811724266e-19 ko05033 Nicotine addiction 34/965 56/7206 1.36040065997e-16 ko05032 Morphine addiction 50/965 110/7206 1.42534851457e-16 ko04727 GABAergic synapse 49/965 110/7206 7.94655423955e-16 ko04744 Phototransduction 26/965 36/7206 9.78318084455e-16 ko04713 Circadian entrainment 53/965 136/7206 4.72243179113e-14 ko04728 Dopaminergic synapse 64/965 185/7206 7.97106303837e-14 ko04721 Synaptic vesicle cycle 38/965 80/7206 1.17957555183e-13 ko04723 Retrograde endocannabinoid signaling 60/965 175/7206 7.70508753877e-13 ko04725 Cholinergic synapse 55/965 160/7206 6.36979201673e-12 ko04024 cAMP signaling pathway 76/965 279/7206 4.26975379969e-10 ko04911 Insulin secretion 41/965 117/7206 1.68518275349e-09 ko04921 Oxytocin signaling pathway 59/965 209/7206 1.059454629e-08 ko05322 Systemic lupus erythematosus 1/965 151/7206 1.64446321295e-08 ko04726 Serotonergic synapse 43/965 137/7206 3.23775003918e-08 ko04020 Calcium signaling pathway 68/965 265/7206 5.59016365262e-08 ko03040 Spliceosome 2/965 145/7206 3.86547343282e-07 ko04070 Phosphatidylinositol signaling system 35/965 112/7206 7.45111724602e-07 ko03013 RNA transport 4/965 166/7206 1.34605446693e-06 ko04261 Adrenergic signaling in cardiomyocytes 52/965 205/7206 3.17280910451e-06 ko04742 Taste transduction 22/965 61/7206 6.03569833063e-06 ko04072 Phospholipase D signaling pathway 49/965 197/7206 1.02431473533e-05 ko05031 Amphetamine addiction 28/965 91/7206 1.38082204183e-05 ko05203 Viral carcinogenesis 15/965 277/7206 1.91960081733e-05 ko04720 Long-term potentiation 28/965 99/7206 7.55751799669e-05 ko04110 Cell cycle 5/965 145/7206 0.000100742155301 ko05030 Cocaine addiction 22/965 73/7206 0.000168307565596 ko04120 Ubiquitin mediated proteolysis 5/965 138/7206 0.00019844637204 ko04514 Cell adhesion molecules (CAMs) 33/965 130/7206 0.00021254392456 ko04966 Collecting duct acid secretion 11/965 26/7206 0.000264992284226 ko04710 Circadian rhythm 15/965 43/7206 0.000279109142395 ko04972 Pancreatic secretion 28/965 111/7206 0.000646783643535 ko04970 Salivary secretion 25/965 95/7206 0.000671053058899 ko04925 Aldosterone synthesis and secretion 27/965 105/7206 0.000704769545854 ko00562 Inositol phosphate metabolism 24/965 89/7206 0.00075172138782 ko05168 Herpes simplex infection 10/965 182/7206 0.000833885378541 ko05164 Influenza A 9/965 167/7206 0.00115124705162 ko04730 Long-term depression 21/965 78/7206 0.00122917476709 ko04141 Protein processing in endoplasmic reticulum 11/965 184/7206 0.00194179770858 ko05130 Pathogenic Escherichia coli infection 2/965 77/7206 0.00212228858811 ko04612 Antigen processing and presentation 2/965 77/7206 0.00212228858811 ko04964 Proximal tubule bicarbonate reclamation 10/965 29/7206 0.00318611276941 ko05016 Huntington's disease 15/965 215/7206 0.00415736646919 ko04010 MAPK signaling pathway 61/965 321/7206 0.00419086621713 ko04022 cGMP-PKG signaling pathway 44/965 216/7206 0.0042363566043 ko04740 Olfactory transduction 20/965 80/7206 0.00445709730516 ko05166 HTLV-I infection 24/965 292/7206 0.00642471956197 ko05169 Epstein-Barr virus infection 15/965 206/7206 0.00679716582597 ko00280 Valine, leucine and isoleucine degradation 1/965 54/7206 0.0077185473292 ko00520 Amino sugar and nucleotide sugar metabolism 1/965 55/7206 0.00805264553293 ko05205 Proteoglycans in cancer 22/965 271/7206 0.00813604848072 ko05110 Vibrio cholerae infection 16/965 63/7206 0.00865281621139 ko05162 Measles 7/965 120/7206 0.0100982973312 ko04745 Phototransduction - fly 11/965 38/7206 0.0132071499878 ko02010 ABC transporters 11/965 39/7206 0.0147104615441 ko04260 Cardiac muscle contraction 22/965 98/7206 0.01557279605 ko04971 Gastric acid secretion 22/965 98/7206 0.01557279605 ko03420 Nucleotide excision repair 1/965 46/7206 0.0166055025439 ko05224 Breast cancer 13/965 174/7206 0.0176872170647 ko04960 Aldosterone-regulated sodium reabsorption 11/965 41/7206 0.0189939416107 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 18/965 79/7206 0.0192897098416 ko04510 Focal adhesion 20/965 240/7206 0.0201573272197 ko04711 Circadian rhythm - fly 5/965 13/7206 0.0216869422543 ko05161 Hepatitis B 13/965 173/7206 0.0230100899524 ko03022 Basal transcription factors 1/965 44/7206 0.0245704135666 ko04930 Type II diabetes mellitus 13/965 54/7206 0.0271570078853 ko05231 Choline metabolism in cancer 27/965 134/7206 0.028434313382 ko04750 Inflammatory mediator regulation of TRP channels 25/965 122/7206 0.0305704142808 ko04014 Ras signaling pathway 50/965 279/7206 0.0308594691781 ko04621 NOD-like receptor signaling pathway 12/965 157/7206 0.0323096189809 ko05211 Renal cell carcinoma 6/965 96/7206 0.0346910050277 ko05020 Prion diseases 1/965 40/7206 0.0360924148891 ko05220 Chronic myeloid leukemia 5/965 85/7206 0.0372074475901 ko05323 Rheumatoid arthritis 19/965 89/7206 0.0396667958979 ko05200 Pathways in cancer 51/965 492/7206 0.0397650580158 ko04371 Apelin signaling pathway 33/965 177/7206 0.0438149163539 ko04666 Fc gamma R-mediated phagocytosis 24/965 122/7206 0.0444372004988