ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 49/161 423/7206 5.07422604314e-23 ko04724 Glutamatergic synapse 25/161 152/7206 2.09080482504e-15 ko05033 Nicotine addiction 14/161 56/7206 1.12942069823e-11 ko04728 Dopaminergic synapse 20/161 185/7206 3.91700237591e-09 ko04727 GABAergic synapse 15/161 110/7206 1.68564875045e-08 ko05014 Amyotrophic lateral sclerosis (ALS) 12/161 74/7206 6.80106114424e-08 ko04742 Taste transduction 11/161 61/7206 7.84336587591e-08 ko04024 cAMP signaling pathway 22/161 279/7206 2.06681694232e-07 ko04723 Retrograde endocannabinoid signaling 17/161 175/7206 3.00623419418e-07 ko04713 Circadian entrainment 14/161 136/7206 1.76395047422e-06 ko04720 Long-term potentiation 11/161 99/7206 1.13725732352e-05 ko04261 Adrenergic signaling in cardiomyocytes 16/161 205/7206 1.21450481553e-05 ko05030 Cocaine addiction 9/161 73/7206 3.16702410546e-05 ko05031 Amphetamine addiction 10/161 91/7206 3.17686126814e-05 ko04726 Serotonergic synapse 12/161 137/7206 5.1088267777e-05 ko04514 Cell adhesion molecules (CAMs) 11/161 130/7206 0.000144455464901 ko05032 Morphine addiction 10/161 110/7206 0.000161101114492 ko04015 Rap1 signaling pathway 15/161 278/7206 0.00132804516944 ko04721 Synaptic vesicle cycle 7/161 80/7206 0.00197354223864 ko04020 Calcium signaling pathway 14/161 265/7206 0.00233850163383 ko04921 Oxytocin signaling pathway 12/161 209/7206 0.00241766834727 ko04725 Cholinergic synapse 10/161 160/7206 0.00300863362428 ko04071 Sphingolipid signaling pathway 10/161 162/7206 0.00329131565813 ko00430 Taurine and hypotaurine metabolism 3/161 14/7206 0.00332432231579 ko02024 Quorum sensing 3/161 15/7206 0.00408781358947 ko04010 MAPK signaling pathway 15/161 321/7206 0.00587142855192 ko04014 Ras signaling pathway 13/161 279/7206 0.0110373403658 ko04972 Pancreatic secretion 7/161 111/7206 0.0118918314 ko05414 Dilated cardiomyopathy 7/161 112/7206 0.0124533192728 ko04072 Phospholipase D signaling pathway 10/161 197/7206 0.0126135250777 ko04911 Insulin secretion 7/161 117/7206 0.0155509451159 ko04970 Salivary secretion 6/161 95/7206 0.0192394673808 ko00650 Butanoate metabolism 3/161 26/7206 0.0195265031526 ko05203 Viral carcinogenesis 1/161 277/7206 0.0217196223144 ko04260 Cardiac muscle contraction 6/161 98/7206 0.0220746907876 ko04540 Gap junction 7/161 128/7206 0.0242266647981 ko04022 cGMP-PKG signaling pathway 10/161 216/7206 0.0296343178353 ko04925 Aldosterone synthesis and secretion 6/161 105/7206 0.0297561048726 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 5/161 79/7206 0.0313649750577 ko04940 Type I diabetes mellitus 3/161 32/7206 0.0338133812004 ko00604 Glycosphingolipid biosynthesis - ganglio series 2/161 14/7206 0.0378590974122 ko04961 Endocrine and other factor-regulated calcium reabsorption 4/161 59/7206 0.0422953578154 ko00410 beta-Alanine metabolism 3/161 35/7206 0.0425211984949 ko05034 Alcoholism 10/161 238/7206 0.0444118988799