ko pathway ratio_in_study ratio_in_pop p_value ko05164 Influenza A 34/309 167/7206 1.09476181361e-14 ko04621 NOD-like receptor signaling pathway 31/309 157/7206 4.2197739596e-13 ko04060 Cytokine-cytokine receptor interaction 33/309 191/7206 3.59066746237e-12 ko05162 Measles 26/309 120/7206 3.86137431748e-12 ko05340 Primary immunodeficiency 14/309 30/7206 4.15793786587e-12 ko04380 Osteoclast differentiation 27/309 134/7206 9.03766977605e-12 ko05140 Leishmaniasis 20/309 75/7206 2.26422666609e-11 ko04064 NF-kappa B signaling pathway 22/309 96/7206 5.79139600961e-11 ko04650 Natural killer cell mediated cytotoxicity 22/309 97/7206 7.20297754655e-11 ko04217 Necroptosis 29/309 178/7206 3.42819737566e-10 ko05145 Toxoplasmosis 24/309 126/7206 4.63735434056e-10 ko04620 Toll-like receptor signaling pathway 21/309 100/7206 9.06954943668e-10 ko05152 Tuberculosis 29/309 187/7206 1.14141318548e-09 ko05321 Inflammatory bowel disease (IBD) 15/309 56/7206 7.17610223012e-09 ko05167 Kaposi's sarcoma-associated herpesvirus infection 28/309 191/7206 8.19656909101e-09 ko05168 Herpes simplex infection 27/309 182/7206 1.18276535653e-08 ko05161 Hepatitis B 26/309 173/7206 1.6966024714e-08 ko04612 Antigen processing and presentation 17/309 77/7206 1.7121432903e-08 ko05330 Allograft rejection 10/309 24/7206 2.09021120931e-08 ko04660 T cell receptor signaling pathway 21/309 124/7206 5.16858259167e-08 ko05133 Pertussis 17/309 87/7206 1.16803656084e-07 ko05150 Staphylococcus aureus infection 11/309 36/7206 1.73519748969e-07 ko05320 Autoimmune thyroid disease 10/309 29/7206 1.76204800176e-07 ko04672 Intestinal immune network for IgA production 11/309 37/7206 2.37596285051e-07 ko05144 Malaria 12/309 45/7206 2.5134086691e-07 ko04622 RIG-I-like receptor signaling pathway 13/309 62/7206 1.60426443207e-06 ko04659 Th17 cell differentiation 17/309 106/7206 2.19423602989e-06 ko05310 Asthma 7/309 17/7206 3.34364505279e-06 ko05332 Graft-versus-host disease 7/309 18/7206 5.27159036537e-06 ko04610 Complement and coagulation cascades 14/309 79/7206 5.28191275343e-06 ko04623 Cytosolic DNA-sensing pathway 10/309 41/7206 6.2292734746e-06 ko04630 Jak-STAT signaling pathway 18/309 132/7206 1.17797605969e-05 ko00120 Primary bile acid biosynthesis 7/309 20/7206 1.19209317018e-05 ko04658 Th1 and Th2 cell differentiation 15/309 96/7206 1.21567982033e-05 ko04668 TNF signaling pathway 17/309 120/7206 1.23593391527e-05 ko04145 Phagosome 20/309 162/7206 1.755745939e-05 ko05323 Rheumatoid arthritis 14/309 89/7206 2.19799248822e-05 ko04062 Chemokine signaling pathway 22/309 201/7206 4.50141256038e-05 ko04662 B cell receptor signaling pathway 13/309 88/7206 8.47839622382e-05 ko05160 Hepatitis C 18/309 153/7206 8.80209255721e-05 ko05142 Chagas disease (American trypanosomiasis) 16/309 130/7206 0.000127106713502 ko04137 Mitophagy - animal 12/309 82/7206 0.000173830211992 ko04940 Type I diabetes mellitus 7/309 32/7206 0.000331906693221 ko04664 Fc epsilon RI signaling pathway 11/309 77/7206 0.00040022755803 ko05132 Salmonella infection 12/309 98/7206 0.000922830759873 ko05134 Legionellosis 10/309 74/7206 0.00113766673149 ko04640 Hematopoietic cell lineage 9/309 64/7206 0.00149991441138 ko00590 Arachidonic acid metabolism 8/309 52/7206 0.00151105069195 ko05166 HTLV-I infection 24/309 292/7206 0.00180743129986 ko03050 Proteasome 8/309 54/7206 0.0019396714479 ko04210 Apoptosis 17/309 180/7206 0.00211425205314 ko05416 Viral myocarditis 8/309 55/7206 0.00218716332809 ko05131 Shigellosis 10/309 82/7206 0.00250427716849 ko05034 Alcoholism 2/309 238/7206 0.00307075772517 ko04670 Leukocyte transendothelial migration 15/309 151/7206 0.00323235241866 ko04514 Cell adhesion molecules (CAMs) 13/309 130/7206 0.00367590064111 ko04657 IL-17 signaling pathway 10/309 87/7206 0.00387924005287 ko04080 Neuroactive ligand-receptor interaction 7/309 423/7206 0.00403095971625 ko05169 Epstein-Barr virus infection 18/309 206/7206 0.00421958819523 ko04310 Wnt signaling pathway 1/309 181/7206 0.00490383423684 ko04728 Dopaminergic synapse 1/309 185/7206 0.00495439099891 ko04666 Fc gamma R-mediated phagocytosis 12/309 122/7206 0.0059039627795 ko05224 Breast cancer 1/309 174/7206 0.0071369863494 ko04933 AGE-RAGE signaling pathway in diabetic complications 13/309 135/7206 0.00762339804169 ko05146 Amoebiasis 10/309 99/7206 0.00962748467912 ko05143 African trypanosomiasis 5/309 32/7206 0.0108988023303 ko04142 Lysosome 13/309 151/7206 0.0138775890714 ko05012 Parkinson's disease 1/309 155/7206 0.0149638736017 ko04611 Platelet activation 14/309 163/7206 0.0161988099604 ko04530 Tight junction 3/309 228/7206 0.0189456328719 ko04360 Axon guidance 3/309 233/7206 0.0195184019682 ko05418 Fluid shear stress and atherosclerosis 14/309 173/7206 0.0204713856409 ko04390 Hippo signaling pathway 2/309 188/7206 0.0259017739903 ko05016 Huntington's disease 3/309 215/7206 0.0260674082387 ko04713 Circadian entrainment 1/309 136/7206 0.0311262245878 ko04726 Serotonergic synapse 1/309 137/7206 0.0312180684192 ko04916 Melanogenesis 1/309 142/7206 0.0325049320761 ko04910 Insulin signaling pathway 2/309 172/7206 0.0349052993473 ko04020 Calcium signaling pathway 5/309 265/7206 0.0446365424747 ko00190 Oxidative phosphorylation 1/309 127/7206 0.0447941863137 ko01200 Carbon metabolism 1/309 128/7206 0.0449563073889 ko04922 Glucagon signaling pathway 1/309 128/7206 0.0449563073889 ko04540 Gap junction 1/309 128/7206 0.0449563073889 ko04152 AMPK signaling pathway 2/309 161/7206 0.0487032619419 ko04550 Signaling pathways regulating pluripotency of stem cells 2/309 165/7206 0.0491933579394 ko04215 Apoptosis - multiple species 5/309 47/7206 0.0494887774775 ko05010 Alzheimer's disease 3/309 202/7206 0.0498590178655