ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1154	423/7206	2.4453347781e-52
ko05033	Nicotine addiction	50/1154	56/7206	8.23916565871e-34
ko04724	Glutamatergic synapse	89/1154	152/7206	1.34792113105e-33
ko05032	Morphine addiction	71/1154	110/7206	8.4209450178e-31
ko04713	Circadian entrainment	79/1154	136/7206	1.4265662283e-29
ko04727	GABAergic synapse	68/1154	110/7206	7.23121191528e-28
ko04728	Dopaminergic synapse	84/1154	185/7206	1.18364406642e-21
ko04725	Cholinergic synapse	76/1154	160/7206	3.73785136175e-21
ko04721	Synaptic vesicle cycle	50/1154	80/7206	4.37586362886e-21
ko04723	Retrograde endocannabinoid signaling	80/1154	175/7206	6.76682227747e-21
ko04024	cAMP signaling pathway	105/1154	279/7206	3.51250081183e-19
ko04911	Insulin secretion	58/1154	117/7206	1.65060161211e-17
ko04020	Calcium signaling pathway	97/1154	265/7206	7.95577288097e-17
ko04742	Taste transduction	37/1154	61/7206	2.5875633258e-15
ko04921	Oxytocin signaling pathway	78/1154	209/7206	3.14506111804e-14
ko04726	Serotonergic synapse	58/1154	137/7206	1.20921874316e-13
ko04261	Adrenergic signaling in cardiomyocytes	74/1154	205/7206	1.08282945301e-12
ko05031	Amphetamine addiction	42/1154	91/7206	1.02705921425e-11
ko04720	Long-term potentiation	43/1154	99/7206	6.92453847753e-11
ko04744	Phototransduction	23/1154	36/7206	1.16041395682e-10
ko03040	Spliceosome	1/1154	145/7206	3.22854689165e-10
ko04925	Aldosterone synthesis and secretion	42/1154	105/7206	2.51831474172e-09
ko04970	Salivary secretion	39/1154	95/7206	3.89253392718e-09
ko04740	Olfactory transduction	34/1154	80/7206	1.36213535461e-08
ko04360	Axon guidance	71/1154	233/7206	1.81097656318e-08
ko04971	Gastric acid secretion	38/1154	98/7206	3.94511047323e-08
ko05030	Cocaine addiction	31/1154	73/7206	6.08604941384e-08
ko05203	Viral carcinogenesis	16/1154	277/7206	2.38937043883e-07
ko03013	RNA transport	6/1154	166/7206	5.31133614304e-07
ko04022	cGMP-PKG signaling pathway	63/1154	216/7206	7.03171575273e-07
ko05322	Systemic lupus erythematosus	5/1154	151/7206	8.87479630548e-07
ko04010	MAPK signaling pathway	84/1154	321/7206	1.73034594018e-06
ko04060	Cytokine-cytokine receptor interaction	9/1154	191/7206	1.77174896583e-06
ko04924	Renin secretion	31/1154	86/7206	4.62698947051e-06
ko05168	Herpes simplex infection	9/1154	182/7206	4.96480217708e-06
ko04070	Phosphatidylinositol signaling system	37/1154	112/7206	6.48892696744e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1154	74/7206	6.54977266633e-06
ko05164	Influenza A	8/1154	167/7206	9.1261334674e-06
ko04141	Protein processing in endoplasmic reticulum	10/1154	184/7206	1.47015076804e-05
ko04072	Phospholipase D signaling pathway	55/1154	197/7206	1.79271033345e-05
ko04972	Pancreatic secretion	36/1154	111/7206	1.84498464408e-05
ko04745	Phototransduction - fly	17/1154	38/7206	2.65933859847e-05
ko04514	Cell adhesion molecules (CAMs)	39/1154	130/7206	5.2058023103e-05
ko04966	Collecting duct acid secretion	13/1154	26/7206	5.70392233651e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1154	79/7206	6.86802960599e-05
ko05110	Vibrio cholerae infection	23/1154	63/7206	7.47150235326e-05
ko04014	Ras signaling pathway	69/1154	279/7206	0.000118604403447
ko05414	Dilated cardiomyopathy	34/1154	112/7206	0.000126313211593
ko04730	Long-term depression	26/1154	78/7206	0.000135387648166
ko04621	NOD-like receptor signaling pathway	9/1154	157/7206	0.000149600532317
ko04612	Antigen processing and presentation	2/1154	77/7206	0.000260294643581
ko04610	Complement and coagulation cascades	2/1154	79/7206	0.000272799571917
ko03008	Ribosome biogenesis in eukaryotes	2/1154	79/7206	0.000272799571917
ko04976	Bile secretion	26/1154	80/7206	0.000293847945607
ko05140	Leishmaniasis	2/1154	75/7206	0.000385707215323
ko04750	Inflammatory mediator regulation of TRP channels	35/1154	122/7206	0.000399164887233
ko04110	Cell cycle	9/1154	145/7206	0.000524756934835
ko04540	Gap junction	36/1154	128/7206	0.000552016813466
ko04371	Apelin signaling pathway	46/1154	177/7206	0.000558203047292
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1154	59/7206	0.000579489862856
ko05205	Proteoglycans in cancer	24/1154	271/7206	0.000683050873208
ko04260	Cardiac muscle contraction	29/1154	98/7206	0.000705741597944
ko04146	Peroxisome	4/1154	89/7206	0.00120748663312
ko04120	Ubiquitin mediated proteolysis	9/1154	138/7206	0.00137488109742
ko04915	Estrogen signaling pathway	35/1154	131/7206	0.00159432224611
ko04064	NF-kappa B signaling pathway	5/1154	96/7206	0.00184312986723
ko04923	Regulation of lipolysis in adipocytes	23/1154	77/7206	0.00247307572816
ko05169	Epstein-Barr virus infection	18/1154	206/7206	0.00269651939173
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1154	182/7206	0.00280537708346
ko05161	Hepatitis B	14/1154	173/7206	0.00308445106122
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1154	14/7206	0.00321989198343
ko05162	Measles	8/1154	120/7206	0.00353732357434
ko00330	Arginine and proline metabolism	2/1154	61/7206	0.0041548531864
ko00260	Glycine, serine and threonine metabolism	1/1154	48/7206	0.00461792012809
ko05321	Inflammatory bowel disease (IBD)	2/1154	56/7206	0.00579172319231
ko03022	Basal transcription factors	1/1154	44/7206	0.00672994931161
ko05144	Malaria	1/1154	45/7206	0.00681348137329
ko00071	Fatty acid degradation	1/1154	45/7206	0.00681348137329
ko04658	Th1 and Th2 cell differentiation	6/1154	96/7206	0.00709332420263
ko03420	Nucleotide excision repair	1/1154	46/7206	0.00713782057816
ko04657	IL-17 signaling pathway	5/1154	87/7206	0.00730520760814
ko04015	Rap1 signaling pathway	61/1154	278/7206	0.00755229266812
ko00562	Inositol phosphate metabolism	24/1154	89/7206	0.00811403265128
ko00480	Glutathione metabolism	2/1154	55/7206	0.00857177098383
ko00240	Pyrimidine metabolism	8/1154	110/7206	0.00857756839214
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1154	100/7206	0.0088542364806
ko00310	Lysine degradation	4/1154	73/7206	0.00974516434635
ko03018	RNA degradation	5/1154	84/7206	0.0100137705584
ko00590	Arachidonic acid metabolism	2/1154	52/7206	0.0123514173287
ko04912	GnRH signaling pathway	30/1154	122/7206	0.0124751083431
ko04210	Apoptosis	17/1154	180/7206	0.0132223987164
ko04622	RIG-I-like receptor signaling pathway	3/1154	62/7206	0.0135588503133
ko04214	Apoptosis - fly	4/1154	72/7206	0.0140800243918
ko04270	Vascular smooth muscle contraction	36/1154	154/7206	0.0145190205546
ko04922	Glucagon signaling pathway	31/1154	128/7206	0.0145709027047
ko04626	Plant-pathogen interaction	7/1154	18/7206	0.0166253588623
ko04217	Necroptosis	17/1154	178/7206	0.0168268358486
ko05133	Pertussis	6/1154	87/7206	0.0177316735122
ko04964	Proximal tubule bicarbonate reclamation	10/1154	29/7206	0.0178356248685
ko00380	Tryptophan metabolism	2/1154	50/7206	0.0182298575625
ko05215	Prostate cancer	9/1154	111/7206	0.0187054444233
ko03320	PPAR signaling pathway	4/1154	69/7206	0.0194319567483
ko04918	Thyroid hormone synthesis	22/1154	86/7206	0.0249965527528
ko04510	Focal adhesion	26/1154	240/7206	0.0250230210184
ko04115	p53 signaling pathway	5/1154	74/7206	0.0253496537288
ko05219	Bladder cancer	2/1154	48/7206	0.0270305536734
ko04620	Toll-like receptor signaling pathway	8/1154	100/7206	0.0271803037349
ko04630	Jak-STAT signaling pathway	12/1154	132/7206	0.0302150364576
ko05131	Shigellosis	6/1154	82/7206	0.032568207947
ko00500	Starch and sucrose metabolism	1/1154	35/7206	0.0342011043877
ko04916	Melanogenesis	32/1154	142/7206	0.0372747282481
ko04640	Hematopoietic cell lineage	4/1154	64/7206	0.0376615333985
ko00280	Valine, leucine and isoleucine degradation	3/1154	54/7206	0.0382182449357
ko01200	Carbon metabolism	12/1154	128/7206	0.0383304970939
ko00512	Mucin type O-glycan biosynthesis	9/1154	29/7206	0.0388549586976
ko05166	HTLV-I infection	34/1154	292/7206	0.0412595090695
ko04350	TGF-beta signaling pathway	9/1154	103/7206	0.0420075632602
ko04711	Circadian rhythm - fly	5/1154	13/7206	0.0438225271462
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1154	92/7206	0.0445664755722
ko04114	Oocyte meiosis	31/1154	139/7206	0.0468110069008
ko05145	Toxoplasmosis	12/1154	126/7206	0.0490139257804
ko04722	Neurotrophin signaling pathway	35/1154	160/7206	0.0490269266426