ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	175/1014	423/7206	1.91708007719e-46
ko05033	Nicotine addiction	50/1014	56/7206	1.25908840827e-36
ko04724	Glutamatergic synapse	86/1014	152/7206	2.48372462184e-35
ko05032	Morphine addiction	64/1014	110/7206	1.90369618966e-27
ko04727	GABAergic synapse	62/1014	110/7206	1.43311092798e-25
ko04713	Circadian entrainment	70/1014	136/7206	1.5845697088e-25
ko04728	Dopaminergic synapse	83/1014	185/7206	7.79669912277e-25
ko04725	Cholinergic synapse	74/1014	160/7206	3.13018753019e-23
ko04723	Retrograde endocannabinoid signaling	75/1014	175/7206	4.79516241356e-21
ko04721	Synaptic vesicle cycle	47/1014	80/7206	1.08427070517e-20
ko04024	cAMP signaling pathway	98/1014	279/7206	1.28667435012e-19
ko04726	Serotonergic synapse	56/1014	137/7206	6.7694059217e-15
ko04742	Taste transduction	34/1014	61/7206	2.30667353522e-14
ko04911	Insulin secretion	50/1014	117/7206	2.3979214003e-14
ko05031	Amphetamine addiction	42/1014	91/7206	1.19952494642e-13
ko04921	Oxytocin signaling pathway	71/1014	209/7206	1.34315718143e-13
ko04720	Long-term potentiation	44/1014	99/7206	1.64718734067e-13
ko04744	Phototransduction	24/1014	36/7206	6.54693850744e-13
ko04020	Calcium signaling pathway	79/1014	265/7206	1.43534173697e-11
ko04261	Adrenergic signaling in cardiomyocytes	66/1014	205/7206	1.56524954829e-11
ko05030	Cocaine addiction	31/1014	73/7206	2.61742479082e-09
ko04360	Axon guidance	66/1014	233/7206	7.77006385956e-09
ko03040	Spliceosome	1/1014	145/7206	9.03675026803e-09
ko04971	Gastric acid secretion	36/1014	98/7206	1.50369169647e-08
ko04010	MAPK signaling pathway	82/1014	321/7206	2.41878138485e-08
ko04970	Salivary secretion	34/1014	95/7206	7.981175603e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1014	74/7206	2.95689291103e-07
ko05203	Viral carcinogenesis	13/1014	277/7206	3.72678273245e-07
ko04925	Aldosterone synthesis and secretion	35/1014	105/7206	4.90903415936e-07
ko04740	Olfactory transduction	28/1014	80/7206	1.86709729439e-06
ko04072	Phospholipase D signaling pathway	53/1014	197/7206	1.88794125884e-06
ko05168	Herpes simplex infection	6/1014	182/7206	2.16067956021e-06
ko04060	Cytokine-cytokine receptor interaction	7/1014	191/7206	2.42202146832e-06
ko04730	Long-term depression	27/1014	78/7206	3.62754941342e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1014	79/7206	4.78519177128e-06
ko03013	RNA transport	6/1014	166/7206	1.25972399096e-05
ko04014	Ras signaling pathway	66/1014	279/7206	1.36266457972e-05
ko05322	Systemic lupus erythematosus	5/1014	151/7206	1.50011151504e-05
ko04120	Ubiquitin mediated proteolysis	4/1014	138/7206	1.77773537297e-05
ko04972	Pancreatic secretion	33/1014	111/7206	2.16751460152e-05
ko04141	Protein processing in endoplasmic reticulum	8/1014	184/7206	2.19990927813e-05
ko04540	Gap junction	36/1014	128/7206	2.75794744172e-05
ko04621	NOD-like receptor signaling pathway	6/1014	157/7206	3.64673988024e-05
ko04022	cGMP-PKG signaling pathway	53/1014	216/7206	3.68426344748e-05
ko04070	Phosphatidylinositol signaling system	32/1014	112/7206	5.11959566176e-05
ko04260	Cardiac muscle contraction	29/1014	98/7206	5.47948744089e-05
ko04915	Estrogen signaling pathway	36/1014	131/7206	5.93284345823e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1014	59/7206	9.19923318399e-05
ko04745	Phototransduction - fly	15/1014	38/7206	9.78897667624e-05
ko05164	Influenza A	8/1014	167/7206	0.000166389311327
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1014	14/7206	0.000204117563306
ko04514	Cell adhesion molecules (CAMs)	34/1014	130/7206	0.000286663676317
ko05414	Dilated cardiomyopathy	30/1014	112/7206	0.000314897113771
ko04750	Inflammatory mediator regulation of TRP channels	32/1014	122/7206	0.000324388108117
ko04966	Collecting duct acid secretion	11/1014	26/7206	0.000412463652649
ko00240	Pyrimidine metabolism	4/1014	110/7206	0.000468929524108
ko05169	Epstein-Barr virus infection	13/1014	206/7206	0.000512766889866
ko04015	Rap1 signaling pathway	60/1014	278/7206	0.000552097874165
ko04064	NF-kappa B signaling pathway	3/1014	96/7206	0.000569566333326
ko04924	Renin secretion	24/1014	86/7206	0.000796398176997
ko03008	Ribosome biogenesis in eukaryotes	2/1014	79/7206	0.000953943380086
ko04350	TGF-beta signaling pathway	4/1014	103/7206	0.0014073567275
ko04612	Antigen processing and presentation	2/1014	77/7206	0.00141433295646
ko04110	Cell cycle	8/1014	145/7206	0.00153696421776
ko04640	Hematopoietic cell lineage	1/1014	64/7206	0.00159007225009
ko05140	Leishmaniasis	2/1014	75/7206	0.0021349342806
ko03018	RNA degradation	3/1014	84/7206	0.00245186472205
ko04964	Proximal tubule bicarbonate reclamation	10/1014	29/7206	0.00459892677465
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1014	182/7206	0.004772152882
ko00480	Glutathione metabolism	1/1014	55/7206	0.00518343513023
ko04146	Peroxisome	4/1014	89/7206	0.00538593246627
ko04973	Carbohydrate digestion and absorption	13/1014	42/7206	0.00551653707683
ko05205	Proteoglycans in cancer	23/1014	271/7206	0.00562983472861
ko05110	Vibrio cholerae infection	17/1014	63/7206	0.0058295044591
ko04371	Apelin signaling pathway	38/1014	177/7206	0.00606280124609
ko04217	Necroptosis	13/1014	178/7206	0.00621042805971
ko04062	Chemokine signaling pathway	42/1014	201/7206	0.00719150720137
ko05162	Measles	7/1014	120/7206	0.00746370226839
ko00590	Arachidonic acid metabolism	1/1014	52/7206	0.00767456057153
ko05034	Alcoholism	48/1014	238/7206	0.00785421680066
ko04912	GnRH signaling pathway	28/1014	122/7206	0.00798779507043
ko05231	Choline metabolism in cancer	30/1014	134/7206	0.00805760652939
ko05214	Glioma	20/1014	79/7206	0.00813222447099
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1014	100/7206	0.00826688397809
ko04976	Bile secretion	20/1014	80/7206	0.00871796582335
ko00330	Arginine and proline metabolism	2/1014	61/7206	0.00914537208142
ko05145	Toxoplasmosis	8/1014	126/7206	0.00929425526894
ko04214	Apoptosis - fly	3/1014	72/7206	0.0101337043054
ko00310	Lysine degradation	3/1014	73/7206	0.0102106044885
ko04960	Aldosterone-regulated sodium reabsorption	12/1014	41/7206	0.0107460479725
ko03320	PPAR signaling pathway	3/1014	69/7206	0.0143376429097
ko03022	Basal transcription factors	1/1014	44/7206	0.0161826442963
ko00071	Fatty acid degradation	1/1014	45/7206	0.0162811326303
ko03420	Nucleotide excision repair	1/1014	46/7206	0.0167711721167
ko04930	Type II diabetes mellitus	14/1014	54/7206	0.0176470424816
ko00515	Mannose type O-glycan biosynthesis	8/1014	25/7206	0.0176494623559
ko05321	Inflammatory bowel disease (IBD)	2/1014	56/7206	0.0191485093849
ko01200	Carbon metabolism	9/1014	128/7206	0.0201282401177
ko04722	Neurotrophin signaling pathway	33/1014	160/7206	0.0209391996799
ko00140	Steroid hormone biosynthesis	1/1014	41/7206	0.0239676410801
ko04012	ErbB signaling pathway	24/1014	109/7206	0.0250478607256
ko05213	Endometrial cancer	15/1014	62/7206	0.0274392132191
ko00600	Sphingolipid metabolism	3/1014	63/7206	0.0283882597432
ko04071	Sphingolipid signaling pathway	33/1014	162/7206	0.0289786564833
ko04923	Regulation of lipolysis in adipocytes	18/1014	77/7206	0.0300784836034
ko04144	Endocytosis	62/1014	342/7206	0.0312359117018
ko04626	Plant-pathogen interaction	6/1014	18/7206	0.0315205356012
ko04270	Vascular smooth muscle contraction	31/1014	154/7206	0.0345243629602
ko05161	Hepatitis B	15/1014	173/7206	0.0356700279507
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1014	40/7206	0.0364462418698
ko04916	Melanogenesis	29/1014	142/7206	0.0371854578523
ko04140	Autophagy - animal	14/1014	164/7206	0.0402789749703
ko04622	RIG-I-like receptor signaling pathway	3/1014	62/7206	0.0409114215651
ko04918	Thyroid hormone synthesis	19/1014	86/7206	0.0410478018794
ko05016	Huntington's disease	20/1014	215/7206	0.0457078423362
ko04114	Oocyte meiosis	28/1014	139/7206	0.0476366035234
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/1014	15/7206	0.0485834305275